Abstract: A dispense system such as an aerosol or pump system includes a container having an upper rim, a collar secured to the upper rim, and a cap removably attached to the collar. The collar may be rotatably secured to the container such that when the cap is rotated, the cap and collar rotate together about the rim of the container without detaching. The cap may enclose an actuator or pump of the container preventing inadvertent dispensing of the contents as well as rendering the container more tamper resistant. Each of the cap and collar includes various features to interlock with one another. In one variation, the cap includes at least one tooth which engages a slot or an opening in the collar to achieve locking. The cap may be rotated or snap fit into place depending on the variation. Caps that are directly mountable to a rim of a container are also disclosed.

Abstract: A dispense system such as an aerosol or pump system includes a container having an upper rim, a collar secured to the upper rim, and a cap removably attached to the collar. The collar may be rotatably secured to the container such that when the cap is rotated, the cap and collar rotate together about the rim of the container without detaching. The cap may enclose an actuator or pump of the container preventing inadvertent dispensing of the contents as well as rendering the container more tamper resistant. Each of the cap and collar includes various features to interlock with one another. In one variation, the cap includes at least one tooth which engages a slot or an opening in the collar to achieve locking. The cap may be rotated or snap fit into place depending on the variation. Caps that are directly mountable to a rim of a container are also disclosed.

Abstract: This combination of clindamycin (1%) and tretinoin (0.025%), solubilized in a hydrogel, resulted in significantly greater improvements in acne vulgaris (reduced lesion counts and ISGA) than either drug alone or vehicle and effectively treated both non-inflammatory and inflammatory lesions with a convenient, once-daily application.

Abstract: A dispense system such as an aerosol or pump system includes a container having an upper rim, a collar secured to the upper rim, and a cap removably attached to the collar. The collar may be rotatably secured to the container such that when the cap is rotated, the cap and collar rotate together about the rim of the container without detaching. The cap may enclose an actuator or pump of the container preventing inadvertent dispensing of the contents as well as rendering the container more tamper resistant. Each of the cap and collar includes various features to interlock with one another. In one variation, the cap includes at least one tooth which engages a slot or an opening in the collar to achieve locking. The cap may be rotated or snap fit into place depending on the variation. Caps that are directly mountable to a rim of a container are also disclosed.

Abstract: A pharmaceutical composition for topical administration, including, as the pharmaceutically active component, at least 5% by weight, based on the total weight of the composition of a piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; an acid in an amount to completely solubilise the piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; a solvent composition including at least two of water, a lower alcohol and a co-solvent selected from one or more of the group consisting of aromatic and polyhydric alcohols; wherein when the co-solvent includes propylene glycol, it is present in an amount of less than approximately 10% by weight.

Abstract: Relaxin is useful for promoting angiogenesis and the treatment of infections or ischemic wounds where the injury results from lack of oxygen due to poor circulation.

Abstract: The present invention relates to a relaxin analogs and derivatives, and uses thereof. The present invention further relates to compositions comprising a relaxin analogs and derivatives, and relaxin wherein such composition exhibits an additive or synergistic effect.

Abstract: The present invention relates to a relaxin-like factor, its derivatives or analogs, and uses thereof. The present invention further relates to compositions comprising a relaxin-like factor, its derivatives or analogs, and relaxin wherein such composition exhibits an additive or synergistic effect.

Abstract: The present invention relates to a relaxin analogs and derivatives, and uses thereof. The present invention further relates to compositions comprising a relaxin analogs and derivatives, and relaxin wherein such composition exhibits an additive or synergistic effect.

Abstract: TCR peptides from the V.beta.5 family, particularly those encompassing at least a part of the second complementarity determining region, are useful, e.g., in the diagnosis and treatment of multiple sclerosis.

Abstract: Depression, particularly disease- and medical treatment-related depression, and especially postpartum depression, is treated by the administration of a therapeutically effective amount of relaxin. A treatment regimen and dosage form for gradual withdrawal from relaxin therapy is also disclosed.