Patents Assigned to Consejo Nacional de Investigaciones Científicas y Técnicas
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Patent number: 11912931Abstract: A polymeric surfactant for use in chemical enhanced oil recovery, including a terpolymer of a first non-ionic monomer, a second non-ionic monomer, and an ionic monomer, the first non-ionic monomer being a hydrophilic monomer and the second non-ionic monomer being a hydrophobic monomer, the ionic monomer being in a lower proportion than the first and second non-ionic monomers. A method of preparation of polymeric surfactants.Type: GrantFiled: July 7, 2022Date of Patent: February 27, 2024Assignees: YPF TECNOLOGÍA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)Inventors: Omar Azzaroni, Juan Martín Giussi, Agustín Iborra, Isabel Vega
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Patent number: 11835665Abstract: A detector of thermal neutrons, fast neutrons and gamma photons that is based on a Cherenkov radiation detector in water and that allows large active volumes of detection at a relatively low cost and higher intensity signals, wherein said detector comprises a container comprising at least a lid; a photon reflective and diffusive coating inside the container; an aqueous solution contained in the container, which comprises sodium chloride (NaCl); and a light sensing device optically coupled to the aqueous solution.Type: GrantFiled: February 4, 2020Date of Patent: December 5, 2023Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), INIS BIOTECH LLC, COMISIÓN NACIONAL DE ENERGÍA ATÓMICA (CNEA)Inventors: Mariano Gómez Berisso, Juan J. Blostein, José Lipovetzky, Martín Pérez, Iván P. Sidelnik, Miguel F. Sofo Haro, Fabricio P. Alcalde Bessia, Luis H. Arnaldi, Hernán G. Asorey
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Publication number: 20230365654Abstract: A method of treating different fibrosis such as liver fibrosis, lung fibrosis or skin fibrosis, wound healing and skin rejuvenation is disclosed by administering a fusion protein having a soluble type II TGF-receptor bound to a stabilizing agent.Type: ApplicationFiled: October 4, 2021Publication date: November 16, 2023Applicants: Consejo Nacional de Investigaciones Científicas y Técnicas, RADBIO USA, IncInventors: Ana Romo, Ricardo Alfredo DEWEY
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Patent number: 11787909Abstract: Acrylamide-derived hydrogels and methods of fabrication thereof from an acrylic monomer, a crosslinking agent comprising an organosilicon compound, a polymerization initiator, a solvent and a polymerization accelerator, as well as their use in controlling circulation losses. The obtained hydrogels interact with the walls of the reservoir and exhibits an increase in viscosity, either at delayed times or in response to a given stimulus, such as changes in temperature, pressure, pH, salinity, using a simple and easily scalable methodology.Type: GrantFiled: December 23, 2019Date of Patent: October 17, 2023Assignees: YPF TECNOLOGIA S.A., UNIVERSIDAD DE BUENOS AIRES, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET).Inventors: Joana Elisa Tasque, Pablo Alejandro Raffo, Isabel Natalia Vega, Norma Beatriz D'Accorso, Darío Alberto Contrera
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Patent number: 11723972Abstract: The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders. Accordingly, the invention relates to compositions, kits, and method for diagnosing, prognosing, monitoring, treating and modulating viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.Type: GrantFiled: September 17, 2019Date of Patent: August 15, 2023Assignees: Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc., Consejo Nacional De Investigaciones Científicas y Técnicas (CONICET), Fundacion SalesInventors: Margaret Shipp, Jing Ouyang, Kunihiko Takeyama, Jeffery L. Kutok, Scott J. Rodig, Gabriel Rabinovich, Diego Omar Croci Russo, Mariana Salatino
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Patent number: 11690376Abstract: A formulation and a composition that comprises it for promoting the pollination of pear crops (Pyrus) by biasing the foraging preferences of the honey bee (Apis mellifera). The formulation comprises the compounds limonene, linalool and ?-pinene. Additionally, a method for targeting the bees' pollination activity towards the pear crops by using the formulation comprising the compounds limonene, linalool and ?-pinene.Type: GrantFiled: July 25, 2018Date of Patent: July 4, 2023Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD DE BUENOS AIRESInventors: Walter M. Farina, Paula Carolina Díaz
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Publication number: 20230184767Abstract: Methods of detecting presence of a virus in a sample are provided, the method including contacting the sample with a solid state nanopore comprising a plurality of virus-specific aptamers and measuring a current-voltage curve in the solid state nanopore, wherein a decrease in the current indicates presence of the virus in the sample. Solid state nanopores comprising a plurality of virus-specific aptamers covalently linked to the interior of the solid state nanopore are also provided. Membranes including a plurality of solid state nanopores including a plurality of covalently attached virus-specific aptamers and kits and systems with a membrane including a plurality of solid state nanopores including a plurality of covalently attached virus-specific aptamers are also provided.Type: ApplicationFiled: May 19, 2021Publication date: June 15, 2023Applicants: The Board of Trustees of the University of Illinois, Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Cientificas y TecnicasInventors: Yi Lu, Ana Sol Peinetti, Omar Azzaroni
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Patent number: 11674199Abstract: Pyrometallurgic process for obtaining lithium compounds and intermediates, the process being characterized by comprising the steps of a) contacting lithium aluminosilicate particles with at least a fluorine solid compound, b) heating until a temperature of 25 to 900° C. obtaining a solid mixture and c) carrying out at least a leaching process of the mixture in step b).Type: GrantFiled: November 23, 2018Date of Patent: June 13, 2023Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS CONICTE, UNIVERSIDAD NACIONAL DE CUYOInventors: Mario Humberto Rodriguez, Alexander Cristian Resentera Beiza, Gustavo Daniel Rosales
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Patent number: 11668664Abstract: A method and device for detection of solid organic matter and fluids in a shale rock by means of low field Nuclear Magnetic Resonance (NMR) in a single measurement, by submitting a rock sample to a 2D NMR assay comprising applying a 2D pulse sequence with a saturation-recovery, or inversion-recovery, in an indirect dimension and an FID-CPMG in a direct dimension. The method can be used as an analytical technique for rock samples from unconventional hydrocarbon reservoirs.Type: GrantFiled: October 27, 2020Date of Patent: June 6, 2023Assignees: YPF TECNOLOGIA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET), UNIVERSIDAD NACIONAL DE CORDOBAInventors: Rodolfo Hector Acosta, Emilia Victoria Silletta, Gustavo Alberto Monti, Yamila Garro Linck, Paula Cecilia Bedini, Gabriela Soledad Vila, Diana María Masiero, Esteban Alejo Domené, Manuel Isaac Velasco
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Patent number: 11627740Abstract: A glycoside compound of fatty acids that includes the general formula: GalNAc-GalNAc-Glc-O—R, where GalNAc is ?- or ?-D-N-acetylgalactosamine, Glc-O—R is a molecule of ?- or ?-D-glucose esterified to a monounsaturated fatty acid (R), where R is selected from 12:1(n) and where n is an integer between 2 and 11; 11:1(n) and where n is an integer between 2 and 10; 10:1(n), and where n is an integer between 2 and 9; 9:1(n), and where n is an integer between 2 and 8; 8:1(n), and where n is an integer between 2 and 8; 7:1(n) and where n is an integer between 2 and 7; and 6:1(n), and where n is an integer between 2 and 6. The compound has activity against plant pathogens, and induces the defense, and promotes the growth, of plants.Type: GrantFiled: September 5, 2018Date of Patent: April 18, 2023Assignees: Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), ESTACION EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRESInventors: Atilio Pedro Castagnaro, Maria Paula Filippone, Bjorn Gunnar Viking Welin, Carlos Froilan Grellet Bournonville, Alicia Ines de Fatima Mamaní, Pía de los Angeles Di Peto
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Patent number: 11618903Abstract: The invention relates to methods for improving abiotic stress tolerance (and/or yield) in plants, including enhanced drought tolerance. It discloses nucleic acid constructs comprising the isolated polynucleotides, transgenic plants expressing the same, and methods of using the same for increasing abiotic stress tolerance (and/or yield).Type: GrantFiled: December 20, 2018Date of Patent: April 4, 2023Assignees: INSTITUTO NACIONAL DE INVESTIGACION AGROPECUARIA, UNIVERSIDAD DE LA REPUBLICA, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS, ESTACION EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRESInventors: Julio Omar Borsani Cambón, Esteban Casaretto De Gregorio, Juan Pablo Gallino Malcuori, Andrea Luciana Fleitas Belamendia, Maria Victoria Bonnecarrère Martinez, Atilio Pedro Castagnaro, Esteban Mariano Pardo, Sabina Vidal Macchi
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Patent number: 11598704Abstract: A device and method for testing a rock specimen in order to determine the fracture toughness (KIC) thereof. The device comprises: a frame; a hydraulic pressure testing rig supported by the frame and comprising a pressure gauge, a lever and a pressure diaphragm; a storage tank for storing hydraulic fluid and supported by the frame; and a pressure chamber supported by the frame, in which the test specimen is placed to be subjected to hydrostatic pressure through conduits that connect said pressure chamber with the storage tank in fluid communication.Type: GrantFiled: November 5, 2020Date of Patent: March 7, 2023Assignees: YPF TECNOLOGÍA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)Inventors: Santiago Serebrinsky, Humberto Celleri, Walter Morris, Anibal Márquez, Juan Belmonte
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Patent number: 11533916Abstract: Disclosed is a bioinsecticide formulation comprising highly resistant Beauveria bassiana microsclerotia and to its use for insect control, in particular for control of insects in grain silos, and to a method of preparation of said formulation. The microsclerotia are obtained in a culture medium comprising an iron (II) compound at a concentration of approximately 0.2 g/L.Type: GrantFiled: March 6, 2020Date of Patent: December 27, 2022Assignees: YPF TECNOLOGÍA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD NACIONAL DE LA PLATA (UNLP)Inventors: Sebastián Alejandro Trejo, Sebastián Reinoso, Walter Alberto Vargas, Eliana Abrahamovich, Nicolás Pedrini, Juan Roberto Girotti, Marta Patricia Juárez
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Patent number: 11535858Abstract: The present invention generally relates to the field of genetic engineering and obtaining transgenic traits for agronomic applications. More specifically, the present invention relates to a specific transgenic event in agricultural crops that improves plant characteristics. Yet more specifically, the invention relates to a polynucleotide construct comprising a gene from Arabidopsis thaliana. In particular, the polynucleotide construct of the invention comprises the gene AtBBX21 which encodes a B-box protein from Arabidopsis thaliana. The transgenic event of the invention increases green and seed yield, reduces photoinhibition, improves water use efficiency, increases tuber and chlorophyll production and improves photosynthetic rates, among others. The polynucleotide construct of the invention comprises a sequence depicted as SEQ ID NO: 1. The invention also provides a transgenic plant transformed with said polynucleotide construct, wherein said plant exhibits improved characteristics.Type: GrantFiled: March 13, 2020Date of Patent: December 27, 2022Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD DE BUENOS AIRESInventors: Javier Francisco Botto, Carlos Daniel Crocco
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Patent number: 11510938Abstract: Method for preventing or treating neuropathic and/or inflammatory pain, wherein said method comprises administering at least one effective dose of the phosphorothioate oligonucleotide IMT504. The preventive method may be applied to a mammal to be subjected to a medical or surgical intervention, or to a mammal that may be injured performing a risky task (for example, a soldier in a battle) to prevent development of pain after a medical intervention or injury.Type: GrantFiled: November 14, 2019Date of Patent: November 29, 2022Assignees: Consejo Nacional de Investigaciones Científicas y Técnicas, Fundacion Pablo Cassara, Universidad AustralInventors: Alejandro Daniel Montaner, Marcelo Jose Villar, Pablo Rodolfo Brumovsky, Candelaria Leiguarda, Maria Florencia Coronel, Inelia Mailín Lara Casadei, Sandra Sbrascini
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Publication number: 20220362279Abstract: A method for the treatment of post-surgical pain in a patient. The method includes: a) administering at least one effective dose of the phosphorothioate oligonucleotide IMT504 to a mammal prior the surgery. The oligonucleotide IMT504 has the nucleotide sequence set forth in SEQ ID No. 1 and b) post-surgery administer a suboptimal amount of an opioid.Type: ApplicationFiled: June 9, 2022Publication date: November 17, 2022Applicants: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS, FUNDACION PABLO CASSARA, UNIVERSIDAD AUSTRALInventors: Alejandro Daniel Montaner, Marcelo Jose Villar, Pablo Rodolfo Brumovsky, Candelaria Leiguarda, Maria Florencia Coronel, Inelia Mailín Lara Casadei, Sandra Sbrascini, Julia Rubione
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Patent number: 11459575Abstract: The present invention relates to modified bacterial polypeptides having immunomodulatory and immunostimulatory activity. Most specifically, the present invention relates to modified bacterial polypeptides having an amino acid sequence selected from SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4 and SEQ ID NO. 5. The modified polypeptides are the adjuvant components of a pharmaceutical composition for eliciting an immune response against an specific antigen present in the pharmaceutical composition. In a preferred embodiment, the invention provides a pharmaceutical composition for a vaccine which comprises an adjuvant component which is any one of the modified polypeptides, one or more antigens, together with a pharmaceutically acceptable excipient.Type: GrantFiled: February 8, 2019Date of Patent: October 4, 2022Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET, UNIVERSIDAD NACIONAL DE GENERAL SAN MARTINInventors: Mirta L. Coria, Karina A. Pasquevich, Juliana Cassataro
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Patent number: 11382913Abstract: A pharmaceutical composition for topical wound treatment comprising one or more nitrogenous heterocyclic compound of 5 or 6 atoms with imide group; one or more deoxyribonuclease enzyme with activity pH between 4.5 and 6.5; and one or more carboxylic acid; kits and process to obtain this pharmaceutical composition and uses for wounds treatment.Type: GrantFiled: May 18, 2021Date of Patent: July 12, 2022Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS, UNIVERSIDAD NACIONAL DE TUCUMAN, UNITECH INC.Inventors: Alberto Ramos Vernieri, Maria De Los Angeles Lazarte, Romina Mabel Chavez Jara, Nicolas Abel Cerusico
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Publication number: 20220054651Abstract: The invention relates to a pharmaceutical composition soluble in an aqueous solution, which is characterised in that it comprises sialoglycosphingolipids; polypeptides selected from the group comprising antibodies, fragments and variants of same; and at least one therapeutically active substance, forming a ternary micellar complex of sialoglycosphingolipid-therapeutically active substance-polypeptide in which the polypeptides are non-covalently associated with the micelles formed by the sialoglycosphingolipid and the therapeutically active substance.Type: ApplicationFiled: December 14, 2018Publication date: February 24, 2022Applicants: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Centro de Excelencia en Productos y Procesos (CEPRECOR)Inventors: Dante Miguel BELTRAMO, Ariel Gustavo GARRO, Roxana Valeria ALASINO, Victoria LEONHARD
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Publication number: 20210371502Abstract: An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain. The isoform comprises the amino acid sequence set forth in SEQ ID No. 12. The isoform may have the amino acid sequence set forth in SEQ ID No. 2 or sequences having at least 85% sequence identity to the sequence set forth in SEQ ID No. 2. A fusion peptide is provided comprising an isoform of the TGF beta II receptor fused to a ligand, wherein a vector comprising the fusion peptide is used to treat cancer and/or hepatic fibrosis. An antibody binding the soluble isoform of the TGF beta II receptor is provided. The antibody binds the amino acid sequence shown in SEQ ID No. 12 and is used in in vitro methods.Type: ApplicationFiled: April 12, 2021Publication date: December 2, 2021Applicants: Consejo Nacional de Investigaciones Científicas y Técnicas, FUNDACIÓN ARTICULAR, INIS BIOTECH LLCInventors: Ana ROMO, Anabela Belen LA COLLA, Matias Adan PREISEGGER, Marcela Soledad BERTOLIO, Ricardo Alfredo DEWEY, Pamela Daiana VAZQUEZ, Andrea Nancy CHISARI, Tania Melina RODRIGUEZ, Benito Jorge VELASCO ZAMORA