Patents Assigned to CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)
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Publication number: 20250041362Abstract: The present invention relates to the delivery of galectins useful in the control of inflammation in diseases associated with inflammatory processes, such as intestinal inflammatory diseases. More particularly, the present invention relates to the delivery of Galectin-1 (Gal1) and Gal1-variants for controlling inflammation in such diseases. More specifically, the present invention relates to the treatment of Intestinal Inflammatory Diseases, in particular ulcerative colitis (UC) and Crohn's disease (CD). Even more specifically, the present invention relates to optimized lactic-acid bacterial strains, capable of producing and secreting considerable levels of human Gal1 and Gal1 variants for delivering galectin-1 into the inflamed tissue. Also, the present invention relates to expression cassettes comprising those Gal1 and variants thereof and the vectors wherein said expression cassettes are contained.Type: ApplicationFiled: November 1, 2022Publication date: February 6, 2025Applicants: UNIVERSIDAD NACIONAL DE ROSARIO, FUNDACIÓN SALES, CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)Inventors: Karina Valeria MARIÑO, Gabriel Adrián RABINOVICH, Victor Sebastian BLANCATO, Marta Alicia TOSCANO, Christian MAGNI, Luciano Gastón MOROSI
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Patent number: 12185721Abstract: A glycoside compound of fatty acids that includes the general formula: GalNAc-GalNAc-Glc-O—R, where GalNAc is ?- or ?-D-N-acetylgalactosamine, Glc-O—R is a molecule of ?- or ?-D-glucose esterified to a monounsaturated fatty acid (R), where R is selected from 12:1(n) and where n is an integer between 2 and 11; 11:1(n) and where n is an integer between 2 and 10; 10:1(n), and where n is an integer between 2 and 9; 9:1(n), and where n is an integer between 2 and 8; 8:1(n), and where n is an integer between 2 and 8; 7:1(n) and where n is an integer between 2 and 7; and 6:1(n), and where n is an integer between 2 and 6. The compound has activity against plant pathogens, and induces the defense, and promotes the growth, of plants.Type: GrantFiled: February 27, 2023Date of Patent: January 7, 2025Assignees: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), ESTACION, EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRESInventors: Atilio Pedro Castagnaro, Maria Paula Filippone, Bjorn Gunnar Viking Welin, Carlos Froilan Grellet Bournonville, Alicia Ines de Fatima Mamaní, Pía de los Angeles Di Peto
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Patent number: 12171234Abstract: A sexual attraction pheromone exclusively obtained from Tribolium castaneum male insects, a method to obtain said pheromone and a device useful for controlling insects in grain silos are disclosed. The device comprises an outer shell, a membrane impregnated with the sexual attraction pheromone and a nucleus containing an insecticide formulation comprising effective amount of an isolated microsclerotia of Beauveria bassiana and an agronomically acceptable carrier.Type: GrantFiled: March 6, 2020Date of Patent: December 24, 2024Assignees: YPF TECNOLOGÍA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD NACIONAL DE LA PLATA (UNLP)Inventors: Sebastián Alejandro Trejo, Sebastián Reinoso, Walter Alberto Vargas, Eliana Abrahamovich, Nicolás Pedrini, Juan Roberto Girotti, Marta Patricia Juárez
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Patent number: 12165320Abstract: A mammographic imaging device for analysis and detection of possible inhomogeneities in breast tissue of a patient using laser light in the near-infrared in diffuse reflectance geometry, includes a patient horizontal support comprising at least one transparent window in its cross-section and a measuring mechanism below the at least one transparent window and carried by said support. The measuring mechanism includes a laser-light producing mechanism for producing laser light beams in the near-infrared, a directing mechanism for directing said laser light beams towards the at least one transparent window, at least one wavelength filter, a light-sensing and imaging mechanism for sensing light and producing images and a controlling, processing and image-normalizing unit for controlling, processing and normalizing images.Type: GrantFiled: December 16, 2019Date of Patent: December 10, 2024Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)Inventors: Pamela A. Pardini, Héctor A. García, María V. Waks Serra, Nicolás A. Carbone, Daniela I. Iriarte, Guido R. Baez, Hector O. Di Rocco, Juan A. Pomarico
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Publication number: 20240237645Abstract: A glycoside compound of fatty acids that includes the general formula: GalNAc-GalNAc-Glc-O—R, where GalNAc is ?- or ?-D-N-acetylgalactosamine, Glc-O—R is a molecule of ?- or ?-D-glucose esterified to a monounsaturated fatty acid (R), where R is selected from 12:1(n) and where n is an integer between 2 and 11; 11:1(n) and where n is an integer between 2 and 10; 10:1(n), and where n is an integer between 2 and 9; 9:1(n), and where n is an integer between 2 and 8; 8:1(n), and where n is an integer between 2 and 8; 7:1(n) and where n is an integer between 2 and 7; and 6:1(n), and where n is an integer between 2 and 6. The compound has activity against plant pathogens, and induces the defense, and promotes the growth, of plants.Type: ApplicationFiled: February 27, 2023Publication date: July 18, 2024Applicants: Consejo Nacional de Investigaciones Científicas y Técnicas (Conicet), ESTACION EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRESInventors: Atilio Pedro Castagnaro, Maria Paula Filippone, Bjorn Gunnar Viking Welin, Carlos Froilan Grellet Bournonville, Alicia Ines de Fatima Mamaní, Pía de los Angeles Di Peto
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Patent number: 12035712Abstract: A formulation and a composition that comprises it for promoting the pollination of pear crops (Pyrus) by biasing the foraging preferences of the honey bee (Apis mellifera). The formulation comprises the compounds limonene, linalool and ?-pinene. Additionally, a method for targeting the bees' pollination activity towards the pear crops by using the formulation comprising the compounds limonene, linalool and ?-pinene.Type: GrantFiled: May 15, 2023Date of Patent: July 16, 2024Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD DE BUENOS AIRESInventors: Walter M. Farina, Paula Carolina Díaz
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Patent number: 11998877Abstract: A method for preparing a super-hydrophobic membrane by cleaning a metal mesh by immersion in an organic solvent; subjecting the cleaned metal mesh to a surface modification treatment to increase its hydrophilicity; coating the treated metal mesh with a hydrophobic organic substance; and drying the metal coated mesh for obtaining the super-hydrophobic membrane. The super-hydrophobic membrane obtained thereby.Type: GrantFiled: February 12, 2019Date of Patent: June 4, 2024Assignees: YPF TECNOLOGIA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)Inventors: Norma Beatriz D'Accorso, Mariana Sosa, Ricardo Martin Negri, Graciela Rojas, María Elena Oneto, Gabriel Lombardo
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Patent number: 11912931Abstract: A polymeric surfactant for use in chemical enhanced oil recovery, including a terpolymer of a first non-ionic monomer, a second non-ionic monomer, and an ionic monomer, the first non-ionic monomer being a hydrophilic monomer and the second non-ionic monomer being a hydrophobic monomer, the ionic monomer being in a lower proportion than the first and second non-ionic monomers. A method of preparation of polymeric surfactants.Type: GrantFiled: July 7, 2022Date of Patent: February 27, 2024Assignees: YPF TECNOLOGÍA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)Inventors: Omar Azzaroni, Juan Martín Giussi, Agustín Iborra, Isabel Vega
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Patent number: 11835665Abstract: A detector of thermal neutrons, fast neutrons and gamma photons that is based on a Cherenkov radiation detector in water and that allows large active volumes of detection at a relatively low cost and higher intensity signals, wherein said detector comprises a container comprising at least a lid; a photon reflective and diffusive coating inside the container; an aqueous solution contained in the container, which comprises sodium chloride (NaCl); and a light sensing device optically coupled to the aqueous solution.Type: GrantFiled: February 4, 2020Date of Patent: December 5, 2023Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), INIS BIOTECH LLC, COMISIÓN NACIONAL DE ENERGÍA ATÓMICA (CNEA)Inventors: Mariano Gómez Berisso, Juan J. Blostein, José Lipovetzky, Martín Pérez, Iván P. Sidelnik, Miguel F. Sofo Haro, Fabricio P. Alcalde Bessia, Luis H. Arnaldi, Hernán G. Asorey
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Patent number: 11787909Abstract: Acrylamide-derived hydrogels and methods of fabrication thereof from an acrylic monomer, a crosslinking agent comprising an organosilicon compound, a polymerization initiator, a solvent and a polymerization accelerator, as well as their use in controlling circulation losses. The obtained hydrogels interact with the walls of the reservoir and exhibits an increase in viscosity, either at delayed times or in response to a given stimulus, such as changes in temperature, pressure, pH, salinity, using a simple and easily scalable methodology.Type: GrantFiled: December 23, 2019Date of Patent: October 17, 2023Assignees: YPF TECNOLOGIA S.A., UNIVERSIDAD DE BUENOS AIRES, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET).Inventors: Joana Elisa Tasque, Pablo Alejandro Raffo, Isabel Natalia Vega, Norma Beatriz D'Accorso, Darío Alberto Contrera
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Patent number: 11723972Abstract: The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders. Accordingly, the invention relates to compositions, kits, and method for diagnosing, prognosing, monitoring, treating and modulating viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.Type: GrantFiled: September 17, 2019Date of Patent: August 15, 2023Assignees: Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc., Consejo Nacional De Investigaciones Científicas y Técnicas (CONICET), Fundacion SalesInventors: Margaret Shipp, Jing Ouyang, Kunihiko Takeyama, Jeffery L. Kutok, Scott J. Rodig, Gabriel Rabinovich, Diego Omar Croci Russo, Mariana Salatino
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Patent number: 11690376Abstract: A formulation and a composition that comprises it for promoting the pollination of pear crops (Pyrus) by biasing the foraging preferences of the honey bee (Apis mellifera). The formulation comprises the compounds limonene, linalool and ?-pinene. Additionally, a method for targeting the bees' pollination activity towards the pear crops by using the formulation comprising the compounds limonene, linalool and ?-pinene.Type: GrantFiled: July 25, 2018Date of Patent: July 4, 2023Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD DE BUENOS AIRESInventors: Walter M. Farina, Paula Carolina Díaz
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Patent number: 11668664Abstract: A method and device for detection of solid organic matter and fluids in a shale rock by means of low field Nuclear Magnetic Resonance (NMR) in a single measurement, by submitting a rock sample to a 2D NMR assay comprising applying a 2D pulse sequence with a saturation-recovery, or inversion-recovery, in an indirect dimension and an FID-CPMG in a direct dimension. The method can be used as an analytical technique for rock samples from unconventional hydrocarbon reservoirs.Type: GrantFiled: October 27, 2020Date of Patent: June 6, 2023Assignees: YPF TECNOLOGIA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET), UNIVERSIDAD NACIONAL DE CORDOBAInventors: Rodolfo Hector Acosta, Emilia Victoria Silletta, Gustavo Alberto Monti, Yamila Garro Linck, Paula Cecilia Bedini, Gabriela Soledad Vila, Diana María Masiero, Esteban Alejo Domené, Manuel Isaac Velasco
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Patent number: 11627740Abstract: A glycoside compound of fatty acids that includes the general formula: GalNAc-GalNAc-Glc-O—R, where GalNAc is ?- or ?-D-N-acetylgalactosamine, Glc-O—R is a molecule of ?- or ?-D-glucose esterified to a monounsaturated fatty acid (R), where R is selected from 12:1(n) and where n is an integer between 2 and 11; 11:1(n) and where n is an integer between 2 and 10; 10:1(n), and where n is an integer between 2 and 9; 9:1(n), and where n is an integer between 2 and 8; 8:1(n), and where n is an integer between 2 and 8; 7:1(n) and where n is an integer between 2 and 7; and 6:1(n), and where n is an integer between 2 and 6. The compound has activity against plant pathogens, and induces the defense, and promotes the growth, of plants.Type: GrantFiled: September 5, 2018Date of Patent: April 18, 2023Assignees: Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), ESTACION EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRESInventors: Atilio Pedro Castagnaro, Maria Paula Filippone, Bjorn Gunnar Viking Welin, Carlos Froilan Grellet Bournonville, Alicia Ines de Fatima Mamaní, Pía de los Angeles Di Peto
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Patent number: 11598704Abstract: A device and method for testing a rock specimen in order to determine the fracture toughness (KIC) thereof. The device comprises: a frame; a hydraulic pressure testing rig supported by the frame and comprising a pressure gauge, a lever and a pressure diaphragm; a storage tank for storing hydraulic fluid and supported by the frame; and a pressure chamber supported by the frame, in which the test specimen is placed to be subjected to hydrostatic pressure through conduits that connect said pressure chamber with the storage tank in fluid communication.Type: GrantFiled: November 5, 2020Date of Patent: March 7, 2023Assignees: YPF TECNOLOGÍA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)Inventors: Santiago Serebrinsky, Humberto Celleri, Walter Morris, Anibal Márquez, Juan Belmonte
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Patent number: 11535858Abstract: The present invention generally relates to the field of genetic engineering and obtaining transgenic traits for agronomic applications. More specifically, the present invention relates to a specific transgenic event in agricultural crops that improves plant characteristics. Yet more specifically, the invention relates to a polynucleotide construct comprising a gene from Arabidopsis thaliana. In particular, the polynucleotide construct of the invention comprises the gene AtBBX21 which encodes a B-box protein from Arabidopsis thaliana. The transgenic event of the invention increases green and seed yield, reduces photoinhibition, improves water use efficiency, increases tuber and chlorophyll production and improves photosynthetic rates, among others. The polynucleotide construct of the invention comprises a sequence depicted as SEQ ID NO: 1. The invention also provides a transgenic plant transformed with said polynucleotide construct, wherein said plant exhibits improved characteristics.Type: GrantFiled: March 13, 2020Date of Patent: December 27, 2022Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD DE BUENOS AIRESInventors: Javier Francisco Botto, Carlos Daniel Crocco
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Patent number: 11533916Abstract: Disclosed is a bioinsecticide formulation comprising highly resistant Beauveria bassiana microsclerotia and to its use for insect control, in particular for control of insects in grain silos, and to a method of preparation of said formulation. The microsclerotia are obtained in a culture medium comprising an iron (II) compound at a concentration of approximately 0.2 g/L.Type: GrantFiled: March 6, 2020Date of Patent: December 27, 2022Assignees: YPF TECNOLOGÍA S.A., CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD NACIONAL DE LA PLATA (UNLP)Inventors: Sebastián Alejandro Trejo, Sebastián Reinoso, Walter Alberto Vargas, Eliana Abrahamovich, Nicolás Pedrini, Juan Roberto Girotti, Marta Patricia Juárez
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Patent number: 11459575Abstract: The present invention relates to modified bacterial polypeptides having immunomodulatory and immunostimulatory activity. Most specifically, the present invention relates to modified bacterial polypeptides having an amino acid sequence selected from SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4 and SEQ ID NO. 5. The modified polypeptides are the adjuvant components of a pharmaceutical composition for eliciting an immune response against an specific antigen present in the pharmaceutical composition. In a preferred embodiment, the invention provides a pharmaceutical composition for a vaccine which comprises an adjuvant component which is any one of the modified polypeptides, one or more antigens, together with a pharmaceutically acceptable excipient.Type: GrantFiled: February 8, 2019Date of Patent: October 4, 2022Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET, UNIVERSIDAD NACIONAL DE GENERAL SAN MARTINInventors: Mirta L. Coria, Karina A. Pasquevich, Juliana Cassataro
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Publication number: 20220054651Abstract: The invention relates to a pharmaceutical composition soluble in an aqueous solution, which is characterised in that it comprises sialoglycosphingolipids; polypeptides selected from the group comprising antibodies, fragments and variants of same; and at least one therapeutically active substance, forming a ternary micellar complex of sialoglycosphingolipid-therapeutically active substance-polypeptide in which the polypeptides are non-covalently associated with the micelles formed by the sialoglycosphingolipid and the therapeutically active substance.Type: ApplicationFiled: December 14, 2018Publication date: February 24, 2022Applicants: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Centro de Excelencia en Productos y Procesos (CEPRECOR)Inventors: Dante Miguel BELTRAMO, Ariel Gustavo GARRO, Roxana Valeria ALASINO, Victoria LEONHARD
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Patent number: 10995610Abstract: Tracers for oil recovery, particularly fluorescent nanotracers conservative in aqueous phases. The tracer comprises a core-shell nanoparticle tailored according to the operation to be traced. It contains a fluorescent core that allows the detection thereof in the field and a functionalized polymeric shell that provides increased stability in high salinity aqueous phases. A method for preparing said nanotracer. Given the nanotracer versatility, it can be used both for tracing fracking steps as well as meshes of secondary and tertiary recovery.Type: GrantFiled: April 26, 2019Date of Patent: May 4, 2021Assignees: YPF Technologia S.A., Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet)Inventors: Alejandra Calvo, María Laura Vera, María Laura Dell'Archiprete, Melina Vanesa Cozzarin, Juan Martín Giussi, Mónica Gonzalez, Félix Gregorio Requejo, Omar Azzaroni