Abstract: Ion sensor based on differential measurement comprising an ISFTET-REFET pair wherein the REFET is defined by a structure composed of an ISFET covered by a microreservoir where an internal reference solution is contained. The sensor comprises a first and a second ion-selective field effect transistor, an electrode, a substrate on the surface whereof are integrated the two transistors, connection tracks and the electrode and a structure adhered on the first ion-selective field effect transistor which creates a microreservoir on the gate of said first transistor, with the microreservoir having a microchannel which connects the microreservoir with the exterior and the microreservoir being filled with the reference solution.

Abstract: The present invention relates to a process for preparing epitaxial ?-quartz layers on a solid substrate, to the material obtained according to this process, and to the various uses thereof, especially in the electronics field.

Abstract: The present invention relates to lymphocytes, preferably that have been transinfected from dendritic cells with a bacterium, preferably CD4+ T cells, preferably Listeria monocytogenes, wherein said bacterium comprises a tumor peptide. It also relates to the use of lymphocytes for therapy and/or treatment of solid tumors, preferably melanoma, the kit or device which comprises for this purpose. Furthermore, it also refers to the transinfection method thereof.

Abstract: A system and a method for liquefaction of gases which are utilized in their liquid state as refrigerants in applications that require low temperatures, throughout various pressure ranges, from slightly above atmospheric pressures to pressures near the critical point. The system and method are based on closed-cycle cryocoolers and utilize the thermodynamic properties of the gas to achieve optimal liquefaction rates.

Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.

Abstract: The subject matter of the invention is an articulation (1) with controllable stiffness and a force-measuring system, comprising a first device (20) that comprises a frame (4) having a curved face and connected to a first motor element (2), the first device (20) regulating the position of the articulation (1), and a second device (22) that regulates the stiffness of the articulation (1) and comprises a thrust element (15), the movement (D) of which determines the pre-compression of a resistive element (11) and thus the stiffness of the articulation (1); the first motor element (2) causes the frame (4) to rotate such that a wheel (8) of the second device (22) rolls on the curved face of the frame (4), causing the resistive element (11) to be compressed (C) via a transmission rod (7) associated with the wheel (8) and with the resistive element (11).

Abstract: A device and a method for obtaining densitometric images which comprise at least one radiological device, at least one depth sensor, and image processing means, which combine the radiological absorption information from the set of recorded radiological images obtained with the radiological systems with the distances of the traversed material, provided by the three-dimensional reconstruction of the objects obtained by means of the depth sensors.

Abstract: Synthesis of the silicoaluminophosphate and metal silicoaluminophosphate polymorphs of the molecular sieve SAPO-18 using cyclic quaternary ammoniums as organic structure-directing agents (OSDA) and use thereof as a catalyst.

Abstract: The main object of the present invention is to provide a new method for preparing the copper-containing silicoaluminate form of the AEI zeolite structure by means of a direct synthesis methodology. This new process involves combining a organometallic copper-complex with an additional organic molecule capable of directing the crystallisation of the silicoaluminate form of the AEI zeolite structure as organic structure-directing agents (OSDAs).

Abstract: The invention relates to methods for increasing total lysine content in plants and plant products and related uses.

Abstract: The present invention relates to a process for the direct synthesis of a material with a CHA zeolite structure in the silicoaluminate form thereof containing copper atoms, which comprises at least the following steps: (i) Preparation of a mixture which contains at least one water source, one copper source, one polyamine, one source of Y tetravalent element, one source of X trivalent element, the tetraethylammonium cation as the only OSDA and one source of alkaline or alkaline earth (A) cations, and wherein the synthesis mixture has the following molar composition: YO2:a X2O3:b OSDA:c A:d H2O:e Cu:f polyamine (ii) Crystallization of the mixture obtained in (i) in a reactor; (iii) Recovery of the crystalline material obtained in (ii).

Abstract: The present invention provides a population of connective tissue derived cells that respond to interferon-gamma (IFN-?) by expressing indolamine-2,3-dioxygenase (IDO) for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to, autoimmune diseases, inflammatory disorders, and immunologically mediated diseases including rejection of transplanted organs and tissues.

Abstract: The invention relates to an aptamer, the structure thereof comprising at least one nucleotide sequence 5?-GGCA(A/G)GGA-3?, that can specifically bind to the poly(A) hairpin of the 5?UTR region of the genome of the human immunodeficiency virus type 1 (HIV-1), providing the method for producing aptamers with said sequence by means of a combination of experimental techniques of in vitro selection of nucleic acids with computational techniques of sequence optimization. The invention also relates to a DNA gene structure for synthesizing said aptamers, preferably RNA. The invention further relates to the different uses of the above-mentioned aptamer, including the use thereof as a biosensor molecule for detecting and/or quantifying HIV-1, as an inhibitor of the production of viral particles of HIV-1, and to the application thereof in medicine, the invention also relating to a method for treating a disease caused by HIV-1, and to a pharmaceutical composition comprising said aptamer.

Abstract: The present invention relates to a new process for synthesising the silicoaluminate form of the AEI zeolite structure based on the use of another zeolite, zeolite Y, as the only source of silicon and aluminum, in order to obtain high synthesis yields (greater than 80%) in the absence of any other source of silicon, phosphine-derivedcationsand fluoride anions in the synthesis medium. The N,N-dimethyl-3,5-dimethylpiperidinium cation may be used as the OSDA, and the FAU crystal structure is transformed into the AEI crystal structure with high yields. It also discloses the preparation of catalysts based on the silicoaluminate form of the AEI crystal structure, wherein Cu atoms have been introduced, and the subsequent application thereof as a catalyst, preferably in the SCR of NOx.

Abstract: The present invention claims an isolated nucleotide sequence characterized by encoding the PFR1 protein of Leishmania infantum or a fragment thereof. This PFR1 protein or a fragment thereof comprises at least a selected immunodominant epitope between the following group: SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 4, SEQ ID No: 5, SEQ ID No: 6, SEQ ID No: 7 and SEQ ID No: 8, where the immunodominant epitope is able to induce an antigen-specific T cell cytotoxic immune response in an animal, against the kinetoplastids causing the leishmaniasis disease. The immunodominant epitopes are cytotoxic T-lymphocyte activators and they present a high binding affinity for A2 type MHC Class I molecule.

Abstract: The present invention relates to a new synthesis process of a crystalline material with the CHA structure, which comprises the following steps: i) Preparation of a mixture that comprises one source of water, one source of a tetravalent element Y, one source of an alkaline or alkaline earth cation (A), one source of a trivalent element X, and one organic molecule (OSDA1) with the structure [R1R2R3R4N+]Q?, being the molar composition: n X2O3:YO2:a A:m OSDA1:z H2O, ii) crystallisation of the mixture obtained in i) in a reactor, iii) recovery of the crystalline material obtained in ii).

Abstract: A lipid nanoparticle that includes at least one antibiotic from the polymyxin family, a lipid fraction, and one or more surfactants. The lipid nanoparticle is useful in the prevention and/or treatment of respiratory tree infections.

Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.

Abstract: An analysis device for a liquid sample comprising: one microfluidic analysis channel made of a wicking material with adequate porosity to allow capillary flow of at least one liquid sample suitable for generating electricity, at least one receiving absorbent region coupled to the microfluidic analysis channel, at least one collecting absorbent region coupled to the microfluidic analysis channel, a cathodic zone coupled to the microfluidic analysis channel, an anodic zone coupled to the microfluidic analysis channel, and at least one detection zone having a sensor, where each receiving absorbent region and each collecting absorbent region are coupled to the microfluidic analysis channel such that when a fluid suitable for generating electricity is deposited in the receiving absorbent region, it flows by capillary action through the microfluidic analysis channel to reach the collecting absorbent region where it is absorbed, and where the sensor interacts with the sample when the latter flows by capillary throug

Abstract: The present invention relates to antibodies binding specifically to CCR9, and to antigen-binding fragments thereof. It also relates to uses thereof and diagnostic methods using said antibodies.