Abstract: The present application provides a combination product for the treatment and/or prevention of psychiatric and/or neurological disorders. The combination product comprises (i) a compound which promotes neurogenesis and has hallucinogenic and/or psychedelic side effects, and (ii) a 5-HT2A receptor antagonist which alleviates and/or removes the hallucinogenic and/or psychedelic side effects caused by the first compound.

Abstract: The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are agonists of neurotrophin (such as nerve growth factor) receptors.

Abstract: Planar optical waveguide interferometer (15, 25, 35, 45) comprising: a substrate (8, 28, 38, 48); a bimodal waveguide (10, 20, 20?, 30, 40) comprising at least one layer (1, 2, 3) deposited on said substrate (8, 28, 38, 48), said bimodal waveguide (10, 20, 20?, 30, 40) being designed for supporting a zero-order and a first-order transverse propagating modes, said transverse propagating modes having different dispersion; a sensor plate (21, 31, 41, 51) located in a selected area of the upper side of said bimodal waveguide (10, 20, 20?, 30, 40), said sensor plate (21, 31, 41, 51) being designed for receiving a chemical, biological or physical stimulus, said stimulus being capable of changing the effective refractive index of said bimodal waveguide (10, 20, 20?, 30, 40). The bimodal waveguide (10, 20, 20?, 30, 40) comprises confining means (9) designed for confining light in lateral direction, the bimodal waveguide (10, 20, 20?, 30, 40) being thus designed for supporting one lateral mode.

Abstract: The invention relates to the use of mediator-enzyme system, which is characterised in that the enzyme comprises a laccase-type enzyme and the mediator comprises a chemical compound which acts as a redox intermediate in the enzymatic oxidation, for the elimination of lipophilic compounds (including, among others, sterols that are free and conjugated in the form of esters and glycosides, triglycerides, fatty alcohols and resin acids) which cause deposits in the product, the machinery and the circuits during the production of pulp and paper (both from hardwood and softwood and non-woody plants). The treatment eliminates up to 100% of the aforementioned lipophilic compounds, depending on the material treated, and, in this way, improves the quality of the pulp obtained, the operation of the industrial installations and the characteristics of the end product.