Abstract: The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of tissue invasion and metastatic capacity.
Type:
Grant
Filed:
November 2, 2006
Date of Patent:
January 27, 2009
Assignees:
Consejo Superior de Investigacoines Cientificas, Universidad Autónoma de Madrid Ciudad Universitaria de Cantoblanco Crta.
Inventors:
Amparo Cano García, Ma Angela Nieto Toledano, Ma Isabel Rodrigo Castro, Annamaria Locascio, Marta García del Barrio, María José Blanco Fernandez de Valderrama, Francisco Portillo Pérez, Mirna Alicia Pérez Moreno