Abstract: Combinations of boron compounds and adjuvants and compositions thereof are suitable for use in a method to induce myotube formation and suppress cell mortality in a mammal in need thereof and for the treatment of epithelial cancers. Compositions comprise boron compounds, adjuvants and support platforms, which enhance the effect of synergistic activation of the boron cell membrane transporter (NaBC1) and adhesion receptors in cells. The combinations and compositions are for the treatment of pathophysiological condition, which affects skeletal muscle, such as dystrophy and epithelial cancer. The combinations and compositions can be included in the field of medical chemistry or pharmacology.
Type:
Application
Filed:
October 4, 2021
Publication date:
December 21, 2023
Applicant:
Consorcio Centro De Investigacion Biomedica En Red, M.P.
Inventors:
Patricia Rico Tortosa, Rafael Castillo Romero, Ana Rodriguez Romano
Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells to provide gene therapy for pyruvate kinase deficiency.
Type:
Application
Filed:
March 8, 2023
Publication date:
November 9, 2023
Applicants:
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A, M.P., Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Consorcio Centro de Investigación Biomédica en Red, M.P.
Inventors:
Jose Carlos SEGOVIA, Maria G. GOMEZ, Susana NAVARRO, Nestor MEZA, Juan Antonio BUEREN, Maria G. BRAVO
Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells to provide gene therapy for pyruvate kinase deficiency.
Type:
Grant
Filed:
October 16, 2018
Date of Patent:
May 9, 2023
Assignees:
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A, M.P., Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Consorcio Centro de Investigación Biomédica en Red, M.P.
Inventors:
Jose Carlos Segovia, Maria G. Gomez, Susana Navarro, Nestor Meza, Juan Antonio Bueren, Maria G. Bravo
Abstract: Specifically, the invention describes obtaining a new porous material prepared to recognise DNA of the pathogenic microorganism Candida albicans, as well as the use thereof in a quick and highly sensitive in vitro diagnostic method.
Type:
Application
Filed:
August 23, 2018
Publication date:
December 30, 2021
Applicants:
Universitat Politècnica de València, Consorcio Centro de Investigacion Biomedica en Red, M.P., Instituto de Investigacion Sanitaria La Fe-Fundacion para la Investigacion del Hospital, Universitat Rovira i Virgili
Inventors:
Àngela RIBES MONPARLER, Elena AZNAR GIMENO, Ramón MARTÍNEZ MÁÑEZ, Félix SANCENÓN GALARZA, María Dolores MARCOS MARTÌNEZ, María Ángeles TORMO MAS, Javier PEMÁN GARCÌA, Lluis Francisco MARSAL GARVI, Elisabet XIFRÉ PÉREZ
Abstract: A graphene transistor system for measuring electrophysiological signals uses flexible epicortical and intracortical arrays of graphene solution-gated field-effect transistors (gSGFETs) to record infraslow signals alongside signals in the typical local field potential bandwidth. The graphene transistor system includes a processing unit, and at least one graphene transistor (gSGFET) a tunable voltage source connected to the drain and source terminals of the transistor (gSGFET), and at least one filter configured to acquire and split the signal from the transistor into at least a low frequency band signal and high frequency band signal, which are amplifiable with a gain value.
Type:
Application
Filed:
May 6, 2021
Publication date:
November 11, 2021
Applicants:
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, CONSORCIO CENTRO DE INVESTIGACIÓN BIOMEDICA EN RED, M.P., INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA), FUNDACIÓ INSTITUT CATALÀ DE NANOCIÈNCIA I NANOTECNOLOGIA (ICN2), INSTITUTO DE INVESTIGACIONES BIOMÉDICAS AUGUST PI SUNYER (IDIBAPS)
Inventors:
Antón GUIMERÁ BRUNET, Eduard MASVIDAL CODINA, Rosa VILLA SANZ, José Antonio GARRIDO ARIZA, Xavier ILLA VILA, Maria Victoria SANCHEZ VIVES
Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells to provide gene therapy for pyruvate kinase deficiency.
Type:
Application
Filed:
October 16, 2018
Publication date:
June 24, 2021
Applicants:
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A, M.P., Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Consorcio Centro de Investigación Biomédica en Red, M.P.
Inventors:
Jose Carlos SEGOVIA, Maria G. GOMEZ, Susana NAVARRO, Nestor MEZA, Juan Antonio BUEREN, Maria G. BRAVO
Abstract: It relates to compositions comprising specific amounts of a hyaluronic acid or a pharmaceutically or veterinary acceptable salt thereof, and two thermoreversible adhesive agents, one of them being a poloxamer, wherein the weight ratio between the poloxamer and the hyaluronic acid or its salt is from 60:1 to 10:1; that may be used as a drug delivery system for the local delivery of active agents to the gastrointestinal tract. It also relates to delivery devices comprising them; and to their uses in medicine, in particular, in the treatment and/or prevention of mucosal lesions; in the prevention of tumor recurrence and reduction of inflammation in the gastrointestinal tract.
Type:
Application
Filed:
July 26, 2017
Publication date:
August 29, 2019
Applicants:
Fundació Institut D'Investigació en Ciències de la Salut Germans Trias i Pujol, Consorcio Centro de Investigación Biomédica en Red, M.P.
Inventors:
Vicente María LORENZO-ZÚÑIGA GARCÍA, Ramon BARTOLÍ SOLÉ, Jaume BOIX VALVERDE