Abstract: In a method for determining a vibration-optimised adjustment of an injection device of an internal combustion engine, for each cycle of the internal combustion engine, a plurality of individual injections per cylinder is carried out by the injection device, each of which is defined by a relative injection moment and an individual injection quantity. A temporal course of a resulting pressure influenced by pressure waves is determined in a fuel guiding part, and the above-mentioned adjustment is determined by variation of the injection moment of at least one individual injection and/or the individual quantity, such that the adjustment is characterized by a temporal variation of the resulting pressure, which is reduced by an at least partially destructive interference between the cited pressure waves. A corresponding device can determine a vibration-optimised adjustment of an injection device, and an internal combustion engine may have such a device.