Patents Assigned to Controlled Chemicals, Inc.
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Patent number: 10201174Abstract: The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.Type: GrantFiled: August 1, 2016Date of Patent: February 12, 2019Assignee: Controlled Chemicals, Inc.Inventors: Jules A. Shafer, Vladislav V. Telyatnikov, Hao Wang
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Patent number: 9617212Abstract: Compounds having an isoindolin-1-one backbone of Formula (I) are disclosed which have utility in treating and/or preventing microbial infections, tumor growth, metastasis and other macrophage migration inhibitory factor (MIF)-modulated pathological conditions. Pharmaceutical compositions and methods and use of compounds of Formula (I) are also disclosed.Type: GrantFiled: December 15, 2014Date of Patent: April 11, 2017Assignee: Controlled Chemicals, Inc.Inventors: Jingliang Jiao, Jules A. Shafer
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Publication number: 20170027199Abstract: The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.Type: ApplicationFiled: August 1, 2016Publication date: February 2, 2017Applicant: Controlled Chemicals, Inc.Inventors: Jules A. Shafer, Vladislav V. Telyatnikov, Hao Wang
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Patent number: 9403838Abstract: The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.Type: GrantFiled: December 30, 2014Date of Patent: August 2, 2016Assignee: Controlled Chemicals, Inc.Inventors: Jules A. Shafer, Vladislav V. Telyatnikov, Hao Wang
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Publication number: 20150175540Abstract: Compounds having an isoindolin-1-one backbone of Formula (I) are disclosed which have utility in treating and/or preventing microbial infections, tumor growth, metastasis and other macrophage migration inhibitory factor (MIF)-modulated pathological conditions. Pharmaceutical compositions and methods and use of compounds of Formula (I) are also disclosed.Type: ApplicationFiled: December 15, 2014Publication date: June 25, 2015Applicant: Controlled Chemicals, Inc.Inventors: Jingliang Jiao, Jules A. Shafer
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Publication number: 20150148537Abstract: The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.Type: ApplicationFiled: December 30, 2014Publication date: May 28, 2015Applicant: Controlled Chemicals, Inc.Inventors: Jules A. Shafer, Vladislav V. Telyatnikov, Hao Wang
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Patent number: 9034893Abstract: The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.Type: GrantFiled: December 6, 2010Date of Patent: May 19, 2015Assignee: Controlled Chemicals, Inc.Inventors: Jules A. Shafer, Vladislav V. Telyatnikov, Hao Wang
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Patent number: 7875623Abstract: The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.Type: GrantFiled: November 22, 2006Date of Patent: January 25, 2011Assignee: Controlled Chemicals, Inc.Inventors: Jules A. Shafer, Vladislav V. Telyatnikov, Hao Wang
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Publication number: 20070203165Abstract: The abuse potential of a bioavailable drug such as an opiate analgesic agent is reduced and its duration of action is extended by converting it to a poorly absorbed ester prodrug or other prodrug derivative prior to formulation. Unlike many existing sustained release formulations of active pharmaceutical agents wherein an active pharmaceutical agent can be released by chewing, crushing, or otherwise breaking tablets or capsule beads containing the active pharmaceutical agent, such mechanical processing of tablets or capsule beads containing a prodrug of this invention neither releases the active drug nor compromises the controlled conversion of prodrug to drug. Moreover, tablets and capsule beads containing prodrugs of this invention or other drugs can be formulated with a sufficient amount of a thickening agent such as hydroxypropylmethylcellulose or carboxymethylcellulose to impede inappropriate intravenous and nasal administration of formulations that are not indicated for these modes of administration.Type: ApplicationFiled: April 30, 2007Publication date: August 30, 2007Applicant: CONTROLLED CHEMICALS, INC.Inventors: Jules Shafer, Vladislav Telyatnikov, Zhiwei Guo
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Publication number: 20070149559Abstract: The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.Type: ApplicationFiled: November 22, 2006Publication date: June 28, 2007Applicant: Controlled Chemicals, Inc.Inventors: Jules Shafer, Vladislav Telyatnikov, Hao Wang
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Patent number: 7230005Abstract: The abuse potential of a bioavailable drug such as an opiate analgesic agent is reduced and its duration of action is extended by converting it to a poorly absorbed ester prodrug or other prodrug derivative prior to formulation. Unlike many existing sustained release formulations of active pharmaceutical agents wherein an active pharmaceutical agent can be released by chewing, crushing, or otherwise breaking tablets or capsule beads containing the active pharmaceutical agent, such mechanical processing of tablets or capsule beads containing a prodrug of this invention neither releases the active drug nor compromises the controlled conversion of prodrug to drug. Moreover, tablets and capsule beads containing prodrugs of this invention or other drugs can be formulated with a sufficient amount of a thickening agent such as hydroxypropylmethylcellulose or carboxymethylcellulose to impede inappropriate intravenous and nasal administration of formulations that are not indicated for these modes of administration.Type: GrantFiled: March 15, 2004Date of Patent: June 12, 2007Assignee: Controlled Chemicals, Inc.Inventors: Jules A. Shafer, Vladislav V. Telyatnikov, Zhiwei Guo
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Publication number: 20040204434Abstract: The abuse potential of a bioavailable drug such as an opiate analgesic agent is reduced and its duration of action is extended by converting it to a poorly absorbed ester prodrug or other prodrug derivative prior to formulation. Unlike many existing sustained release formulations of active pharmaceutical agents wherein an active pharmaceutical agent can be released by chewing, crushing, or otherwise breaking tablets or capsule beads containing the active pharmaceutical agent, such mechanical processing of tablets or capsule beads containing a prodrug of this invention neither releases the active drug nor compromises the controlled conversion of prodrug to drug. Moreover, tablets and capsule beads containing prodrugs of this invention or other drugs can be formulated with a sufficient amount of a thickening agent such as hydroxypropylmethylcellulose or carboxymethylcellulose to impede inappropriate intravenous and nasal administration of formulations that are not indicated for these modes of administration.Type: ApplicationFiled: March 15, 2004Publication date: October 14, 2004Applicant: Controlled Chemicals Inc.Inventors: Jules A. Shafer, Vladislav V. Telyatnikov, Zhiwei Guo