Abstract: A method and system of delivering energy to material in which energy is converted to thermal energy in the material, and prior to significant therapeutic or other physiological change in a selected or target region of the material, results in a temperature rise which is maximum in a selected region of the material but which is insufficient to cause significant therapeutic or other physiological effect, the system for selective preheating of subsurface target regions of material such as human tissue including an energy source to preheat the material or tissue, a passive or active cooling means, and a device for delivering therapeutic or treatment energy, such as pulsed, electromagnetic, laser or non-coherent energy, to tissue during or after the preheating and cooling of the tissue.

Abstract: A laser tissue treatment device capable of being handheld, the device comprising a semiconductor diode or diode array laser which emits energy and a device for surface cooling of tissue such that the energy is directed through said cooling device in contact with tissue. The diode laser operates at wavelengths between about 630 nm and 980 nm, and delivers a predetermined amount of energy in a predetermined period of time and having a predetermined spot size. The device utilizes one or more microlenses or microlens arrays to collimate the diode laser energy. Optionally, the device utilizes a deflecting optic for deflecting the diode laser energy through the cooling device which is in contact with tissue in which the deflecting optic is visually transparent such that the operator can see the tissue treatment area. A cooling device such as a sapphire plate or other active or passive cooling means is used to cool the tissue.