Abstract: An agglutination assay reagent and method. The reagent is composed of liposomes predominantly in the 1 to 20 micron diameter size range. Each liposome has a surface array of laterally mobile ligand molecules, at a surface concentration adapted to produce reagent agglutination within about 5 minutes, when the reagent is incubated at room temperature with a multivalent ligand-binding analyte. A dye in the liposomes allows such agglutination to be visualized easily without magnification.
Type:
Grant
Filed:
July 27, 1983
Date of Patent:
August 12, 1986
Assignee:
Cooper Lipotech Inc.
Inventors:
Viola T. Kung, Francis J. Martin, Yolanda P. Vollmer