Abstract: A pharmaceutical composition comprising as the active principle the piperazine salt of (S) 6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid in highly micronized form, suited carriers in which the active principle is scarcely soluble, surfactants, preserving agents and an hydrophilic, pH-independent, matrix consisting of alkyl derivatives of cellulose and/or polyvinylalcohol. The sustained release of the antiinflammatory compositions allows the treatment of affections by means of a single daily administration of the same.