Patents Assigned to Copenhagen University
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Patent number: 11376230Abstract: The present invention pertains to use of sodium diacetate (NaHAc2) as an antimicrobial agent against bacteria growing in biofilms. The aspects of the invention include a wound care product comprising sodium diacetate, a kit comprising a wound care product, and a method of treating an infected wound.Type: GrantFiled: April 18, 2012Date of Patent: July 5, 2022Assignees: Rigshospitalet Copenhagen University Hospital, Bispebjerg HospitalInventors: Thomas Bjarnsholt, Klaus Kirketerp-Moller, Michael Christian Givskov
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Publication number: 20210230633Abstract: The present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively linked to antigenic protein or peptide encoding sequences. The vaccine stimulates an immune response, especially an immune response in an MHC-I dependent, but CD4+ T-cell independent manner.Type: ApplicationFiled: February 3, 2021Publication date: July 29, 2021Applicant: Copenhagen UniversityInventors: Peter Johannes Holst, Allan Randrup Thomsen, Jan Pravsgaard Christensen
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Patent number: 10246513Abstract: The present invention relates to antagonists or inhibitors, which bind selectively to RANKL/OPGbp and regulate the interaction between RANKL/OPGbp and RANK/OPG. In particular, the present invention relates to an antibody or antigen binding domain, fragment or derivative thereof, immunoreactive with a RANKL/OPGbppeptide for use in the treatment, prevention or alleviation of male infertility or reduced male fertility such as oligospermia or azospermia.Type: GrantFiled: August 4, 2014Date of Patent: April 2, 2019Assignee: RIGSHOSPITALET COPENHAGEN UNIVERSITY HOSPITALInventor: Martin Blomberg Jensen
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Patent number: 9655840Abstract: The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein the product comprises at least one further antibacterial compound; a delivery system comprising a container connected to a means of delivery which is connected to a pad, wherein said container comprises a composition comprising acetic acid and said pad comprises a self-adhesive material; a kit comprising a dressing and an adhesive membrane, wherein the dressing comprises a composition comprising acetic acid; a method of treating a wound comprising a) applying acetic acid to the wound and b) applying a negative pressure to the wound.Type: GrantFiled: December 21, 2010Date of Patent: May 23, 2017Assignees: RIGSHOSPITALET, COPENHAGEN UNIVERSITY HOSPITAL, BISPEBJERG HOSPITALInventors: Michael Christian Givskov, Thomas Bjarnsholt, Klaus Kirketerp-Møller
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Publication number: 20150368672Abstract: The present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively linked to antigenic protein or peptide encoding sequences. The vaccine stimulates an immune response, especially an immune response in an MHC-I dependent, but CD4+ T-cell independent manner.Type: ApplicationFiled: August 4, 2015Publication date: December 24, 2015Applicant: Copenhagen UniversityInventors: Peter Johannes Holst, Allan Randrup Thomsen, Jan Pravsgaard Christensen
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Publication number: 20140272998Abstract: The present invention relates to the field of cancer-diagnostics. In particular the invention relates to a microRNA expression signature that allows discriminating skin samples of cutaneous T-cell lymphomas (CTCL) from non-malignant (inflammantory) skin samples by use of quantitative polymerase chain reaction performed on reverse transcribed miRNA. miR-155, miR-326, miR-663b, miR-203 and miR-205 are shown to be differentially expressed.Type: ApplicationFiled: July 13, 2012Publication date: September 18, 2014Applicants: LEO PHARMA A/S, COPENHAGEN UNIVERSITY, RIGSHOSPITALET, GENTOFTE HOSPITALInventors: Ulrik Ralfkiaer, Peter Hagedorn, Charlotte Busch Ahler, Carsten Geisler, Anders Woetmann, Lone Skov, Niels Feentved Odum, Elisabeth Ralfkiaer
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Publication number: 20140100419Abstract: The present invention relates to methods for improving the ability of spermatozoa to fertilize an egg in vitro and/or vivo, said method comprising providing a medium comprising active vitamin D (calcitriol) or analogs thereof, providing a sample of spermatozoa, and incubating said sample of spermatozoa with said medium. In addition, the invention relates to compositions comprising active vitamin D or analogs thereof for use in the treatment of infertility in a male or female subject.Type: ApplicationFiled: January 31, 2012Publication date: April 10, 2014Applicant: RIGSHOSPITALET COPENHAGEN UNIVERSITY HOSPITALInventor: Martin Blomberg Jensen
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Publication number: 20140046276Abstract: The present invention pertains to use of sodium diacetate (NaHAc2) as an antimicrobial agent against bacteria growing in biofilms. The aspects of the invention include a wound care product comprising sodium diacetate, a kit comprising a wound care product, and a method of treating an infected wound.Type: ApplicationFiled: April 18, 2012Publication date: February 13, 2014Applicants: RIGSHOSPITALET COPENHAGEN UNIVERSITY HOSPITAL, BISPEBJERG HOSPITAL, DANMARKS TEKNISKE UNIVERSITETInventors: Thomas Bjarnsholt, Klaus Kirketerp-Moller, Michael Christian Givskov
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Publication number: 20130060208Abstract: The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein the product comprises at least one further antibacterial compound; a delivery system comprising a container connected to a means of delivery which is connected to a pad, wherein said container comprises a composition comprising acetic acid and said pad comprises a self-adhesive material; a kit comprising a dressing and an adhesive membrane, wherein the dressing comprises a composition comprising acetic acid; a method of treating a wound comprising a) applying acetic acid to the wound and b) applying a negative pressure to the wound.Type: ApplicationFiled: December 21, 2010Publication date: March 7, 2013Applicants: RIGSHOSPITALET, COPENHAGEN UNIVERSITY HOSPITAL, BISPEBJERG HOSPITAL, DANMARKS TEKNISKE UNIVERSITETInventors: Michael Christian Givskov, Thomas Bjarnsholt, Klaus Kirketerp-Møller
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Publication number: 20130045890Abstract: The present invention relates generally to a method for predicting the fertility potential in a male mammal. In particular it relates to a method for predicting the fertility potential in a male mammal by determining the expression of at least one protein of the vitamin D metabolising machinery in a semen sample. The expression level of the at least one protein of the vitamin D metabolising machinery is then indicative of the fertility potential of the subject. An object of the present invention relates to a method, which can predict whether the semen quality is sufficient to achieve pregnancy spontaneously or if the couple should proceed to assisted reproduction or further investigation.Type: ApplicationFiled: May 3, 2011Publication date: February 21, 2013Applicant: Rigshospitalet Copenhagen University HospitalInventors: Martin Blomberg Jensen, John Erik Nielsen, Niels Jorgensen, Kristian Almstrup, Henrik Leffers
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Patent number: 8138148Abstract: The present invention relates to peptide fragments derived from the proteins belonging to the TGFbeta superfamily, pharmaceutical compositions comprising these peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammatory response are beneficial for treatment.Type: GrantFiled: August 15, 2006Date of Patent: March 20, 2012Assignee: Copenhagen UniversityInventors: Elisabeth Bock, Vladimir Berezin
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Patent number: 8008259Abstract: The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated with memory and learning. The peptide sequences of the invention are derived from the proteins belonging to neurotrophic factors, such as NGF, NT3, NT4/5 and BDNF. The invention also relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory are beneficial for treatment.Type: GrantFiled: November 7, 2006Date of Patent: August 30, 2011Assignee: Copenhagen University, Techtrans UnitInventors: Elisabeth Bock, Vladimir Berezin
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Publication number: 20100278904Abstract: The present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively linked to antigenic protein or peptide encoding sequences. The vaccine stimulates an immune response, especially an immune response in an MHC-I dependent, but CD4+ T-cell independent manner.Type: ApplicationFiled: November 30, 2006Publication date: November 4, 2010Applicant: Copenhagen UniversityInventors: Peter Johannes Holst, Allan Randrup Thomsen, Jan Pravsgaard Christensen
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Publication number: 20090221506Abstract: The present invention relates to peptide fragments derived from the proteins belonging to the TGFbeta superfamily, pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammatory response are beneficial for treatment.Type: ApplicationFiled: August 15, 2006Publication date: September 3, 2009Applicant: Copenhagen UniversityInventors: Elisabeth Bock, Vladimir Berezin
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Publication number: 20090074779Abstract: The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated with memory and learning. The peptide sequences of the invention are derived from the proteins belonging to neurotrophic factors, such as NGF, NT3, NT4/5 and BDNF. The invention also relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory are beneficial for treatment.Type: ApplicationFiled: November 7, 2006Publication date: March 19, 2009Applicant: Copenhagen UniversityInventors: Elisabeth Bock, Vladimir Berezin