Patents Assigned to Corassist Cardiovascular Ltd.
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Patent number: 8636642Abstract: The present invention is primarily directed towards an anatomically-compatible and physiologically-compatible in vivo device for improving diastolic function of either the left or right ventricle of the heart, wherein said device comprises at least one elastic component in the form of a lattice capable of being arranged in a curved conformation such that one surface of said lattice may be adapted to the curvature of the external ventricular surface of the heart, or a portion thereof, and wherein said at least one elastic component is capable of being operatively connected to the external ventricular surface of the heart by means of one or more connecting elements.Type: GrantFiled: September 22, 2005Date of Patent: January 28, 2014Assignee: Corassist Cardiovascular Ltd.Inventors: Shay Dubi, Eran Hirszowicz
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Patent number: 8523755Abstract: Devices and methods are provided for assisting in the ventricular function of a treated heart, and tools for delivering and attaching elements of said devices to the wall of the heart. In general the devices are designed to assist in the ventricular function of the heart by utilizing elastic, and/or magnetic, elements designed to apply radially and/or tangentially directed forces over the wall of the heart, and/or alter the pressure conditions inside ventricle(s) of the heart. Embodiments may utilize restrictive elements which may optionally be attached over the heart during the implantation procedure, or at a later time, by changing the mode of operation of an implanted device.Type: GrantFiled: August 11, 2010Date of Patent: September 3, 2013Assignee: Corassist Cardiovascular Ltd.Inventors: Remo Eyal Almog, Amit Tubishevitz
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Patent number: 8500622Abstract: The present invention provides a ventricular function assisting device configured to be implanted in a heart ventricle designed in a form of flower-like configuration comprising two or more petals attached at a base section, said petals comprise elastic elements and/or portions capable of being elastically bent in radial directions and optionally also in sideway and/or longitudinal directions, which allow changing the state of the device between: i) a folded conformation, in which its petals are radially pressed inwardly towards each other to assume a reduced diameter of its flower-like configuration; and ii) a deployed conformation, in which the petals are opened in a radial outward direction as the device is discharged from the delivery tube or sheath into a heart ventricle and implanted thereinside in a preloaded state.Type: GrantFiled: October 20, 2009Date of Patent: August 6, 2013Assignee: Corassist Cardiovascular Ltd.Inventors: Michal Lipperman, Gideon Meyer-Brodnitz, Lior Rosen, Remo Eyal Almog, Amit Tubishevitz
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Patent number: 8382653Abstract: The present invention provides a system for improving diastolic function of the heart comprising elastic elements and attachment elements, wherein said elastic elements and said attachment elements are configured such that they are capable of being interconnected to form a chain formed of an alternating series of said elastic elements and said attachment elements, and wherein said attachment elements are adapted to be anchored in the wall of the heart and with option for drug delivery to the wall of the heart. The invention further provides devices, methods and kits, for mounting the ventricular function assisting device of the invention.Type: GrantFiled: September 25, 2007Date of Patent: February 26, 2013Assignee: Corassist Cardiovascular Ltd.Inventors: Shay Dubi, Igor Kovalsky, Yair Feld, Amir Loshakove, Boaz Nishri, Amit Tubishevitz
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Publication number: 20110313436Abstract: The present invention provides an in vivo device for improving diastolic function of the heart, comprising: at least one elastic component that may be operatively connected to the external surface of the left or right ventricle of the heart by means of connecting elements, wherein said elastic component comprises essentially longitudinal members arranged such that the lateral separation therebetween may be increased or decreased in response to elastic deformation of said elastic component, and wherein said essentially longitudinal members are arranged such that said elastic component is curved in both the vertical and horizontal planes, such that its inner surface may be adapted to the curvature of the external ventricular surface of the heart, such that said elastic component is capable of exerting both radially outward expansive and tangentially-directed forces on the external surface of the cardiac ventricle.Type: ApplicationFiled: August 17, 2011Publication date: December 22, 2011Applicant: CORASSIST CARDIOVASCULAR LTD.Inventors: Shay DUBI, Yair FELD
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Publication number: 20110257461Abstract: The present invention provides a ventricular function assisting device configured to be implanted in a heart ventricle designed in a form of flower-like configuration comprising two or more petals attached at a base section, said petals comprise elastic elements and/or portions capable of being elastically bent in radial directions and optionally also in sideway and/or longitudinal directions, which allow changing the state of the device between: i) a folded conformation, in which its petals are radially pressed inwardly towards each other to assume a reduced diameter of its flower-like configuration; and ii) a deployed conformation, in which the petals are opened in a radial outward direction as the device is discharged from the delivery tube or sheath into a heart ventricle and implanted thereinside in a preloaded state.Type: ApplicationFiled: October 20, 2009Publication date: October 20, 2011Applicant: CORASSIST CARDIOVASCULAR LTD.Inventors: Michal Lipperman, Gideon Meyer-Brodnitz, Lior Rosen, Remo Eyal Almog, Amit Tubishevitz
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Patent number: 7993258Abstract: A method and device featuring at least one component providing a potential to kinetic converted elastic, magnetic repulsion, or, an elastic and magnetic repulsion, pushing, pulling, or, pulling and pushing, type of radially outward expansive force or pressure to an inner, outer, intermediate, and, combination thereof, wall region of the left ventricle, for reducing intraluminal hydrostatic pressure of the left ventricle (LV filling pressure) during the ventricular diastolic stage of the cardiac cycle, thereby, improving diastolic function of the left ventricle of the heart in subjects having a condition of diastolic heart failure (DHF), while minimally disturbing systolic function of the heart. The expansive force or pressure is in a range of about 5-40 mm Hg, whereby, left ventricular end diastolic pressure (LVEDP) is reduced down to the normal range of about 6-12 mm Hg, during ventricular diastole of the heart.Type: GrantFiled: May 10, 2006Date of Patent: August 9, 2011Assignee: Corassist Cardiovascular Ltd.Inventors: Yair Feld, Shay Dubi
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Publication number: 20110092761Abstract: Devices and methods are provided for assisting in the ventricular function of a treated heart, and tools for delivering and attaching elements of said devices to the wall of the heart. In general the devices are designed to assist in the ventricular function of the heart by utilizing elastic, and/or magnetic, elements designed to apply radially and/or tangentially directed forces over the wall of the heart, and/or alter the pressure conditions inside ventricle(s) of the heart. Embodiments may utilize restrictive elements which may optionally be attached over the heart during the implantation procedure, or at a later time, by changing the mode of operation of an implanted device.Type: ApplicationFiled: August 11, 2010Publication date: April 21, 2011Applicant: CORASSIST CARDIOVASCULAR LTD.Inventors: Remo Eyal Almog, Amit Tubishevitz
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Patent number: 7824325Abstract: The present invention provides an anatomically-compatible and physiologically-compatible in vivo device for improving diastolic function of either the left or right ventricle of the heart, comprising at least one air-impermeable sheet that is capable of being operatively connected to the external ventricular surface of the heart using one or more connecting elements, such that said at least one air-impermeable sheet is capable of creating a sub-atmospheric pressure within said closed empty space as a consequence of changes in the volume of said space during the course of the cardiac cycle, thereby exerting an outward and normally directed force on the external ventricular surface of the heart.Type: GrantFiled: October 28, 2004Date of Patent: November 2, 2010Assignee: Corassist Cardiovascular Ltd.Inventor: Shay Dubi
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Publication number: 20100022821Abstract: The present invention provides a system for improving diastolic function of the heart comprising elastic elements and attachment elements, wherein said elastic elements and said attachment elements are configured such that they are capable of being interconnected to form a chain formed of an alternating series of said elastic elements and said attachment elements, and wherein said attachment elements are adapted to be anchored in the wall of the heart and with option for drug delivery to the wall of the heart. The invention further provides devices, methods and kits, for mounting the ventricular function assisting device of the invention.Type: ApplicationFiled: September 25, 2007Publication date: January 28, 2010Applicant: CORASSIST CARDIOVASCULAR LTD.Inventors: Shay Dubi, Igor Kovalsky, Yair Feld, Amir Loshakove, Boaz Nishri, Amit Tubishevitz
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Publication number: 20060241334Abstract: The present invention provides an in vivo device for improving diastolic function of the heart, comprising: at least one elastic component that may be operatively connected to the external surface of the left or right ventricle of the heart by means of connecting elements, wherein said elastic component comprises essentially longitudinal members arranged such that the lateral separation therebetween may be increased or decreased in response to elastic deformation of said elastic component, and wherein said essentially longitudinal members are arranged such that said elastic component is curved in both the vertical and horizontal planes, such that its inner surface may be adapted to the curvature of the external ventricular surface of the heart, such that said elastic component is capable of exerting both radially outward expansive and tangentially-directed forces on the external surface of the cardiac ventricle.Type: ApplicationFiled: January 26, 2004Publication date: October 26, 2006Applicant: Corassist Cardiovascular Ltd.Inventors: Shay Dubi, Yair Feld