Abstract: A gene-drug specific system for classifying individual genetic variants based on strength-of-evidence of clinical utility from published scientific and clinical data that support their effect on modifying drug response and behavior. This allows categorization of the genetic variants into evidence classes that have a wide range of uses such as pharmacogenomic molecular diagnostics and personalized medicine research designed to guide the clinical implementation of PGx. Furthermore, this information can be combined with a knowledgebase of drug-response phenotypes, a knowlegebase of specific drug-induced outcomes and individual patient diplotype information for a gene-drug combination into a programmed computer to output corresponding patient-specific predicted drug responses.
Type:
Application
Filed:
July 1, 2011
Publication date:
January 19, 2012
Applicant:
CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.
Inventors:
Michael F. Christman, Margaret A. Keller, Neda Gharani, Erynn Gordon-Fishman, Catharine B. Stack
Abstract: Albumin-supplemented and xenogeneic product-free cell culture media, cell culture media supplements, and cell culture media kits for the support of primary culture of normal non-hematopoietic cells of mesodermal origin suitable for both research and clinical applications.
Type:
Application
Filed:
October 4, 2006
Publication date:
April 12, 2007
Applicant:
Coriell Institute for Medical Research Inc.
Abstract: A composition is provided, which comprises a purified cytoplasmic extract from eggs of Xenopus laevis which is capable of supporting activation of human sperm and complete replication of a human sperm genome. Methods of using the extract to achieve complete replication of the sperm genome are disclosed. A flow cytometric method for quantitatively monitoring replication of human sperm genomes is also disclosed. This method can be used for clinical assessment of sperm quality in a test sample of human sperm from an infertile male donor.
Abstract: A highly purified arginine deiminase is obtained using a two-step purification procedure. The arginine deiminase is isolated and purified from various species of mycoplasmas and is resistant to proteinase K. The growth of tumor cells can be inhibited by administering proteinase K-resistant arginine deiminase or a PEG-conjugate thereof.