Abstract: The present invention relates to fusion proteins of Mycobacterium tuberculosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.
Type:
Grant
Filed:
February 5, 2003
Date of Patent:
June 20, 2006
Assignee:
Corixa
Inventors:
Yasir Skeiky, Mark Alderson, Antonio Campos-Neto
Abstract: Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.
Type:
Grant
Filed:
April 15, 1997
Date of Patent:
April 25, 2000
Assignee:
Corixa
Inventors:
Steven G. Reed, Yasir A. W. Skeiky, Michael J. Lodes, Raymond L. Houghton
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