Abstract: Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
Type:
Application
Filed:
September 9, 2015
Publication date:
August 4, 2016
Applicant:
CORIXA CORPOATION
Inventors:
Antonio Campos-Neto, Yasir Skeiky, Pamela Ovendale, Shyian Jen, Michael Lodes
Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
Type:
Application
Filed:
September 13, 2005
Publication date:
March 30, 2006
Applicant:
Corixa Corpoation
Inventors:
Raymond Houghton, Paul Sleath, David Persing