Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
Type:
Grant
Filed:
May 6, 2021
Date of Patent:
May 16, 2023
Assignee:
Cornell University
Inventors:
Joseph P. Vacca, Dansu Li, Sarah Bettigole
Abstract: Methods for fabricating flexible/stretchable circuits can include identifying one or more regions of a printed circuit board (PCB) for selectively removing insulation material. The PCB can include one or more electrically conductive structures arranged on an insulation layer. The method can include applying, within each region of the one or more regions, thermal energy via a heat source to a surface of the PCB within the region such that insulation material of the insulation layer is removed from the region while a portion of the insulation layer beneath the one or more electrically conductive structures is maintained. The flexible/stretchable circuit can be laminated on a soft actuator to form a soft robotic device.
Abstract: A computer-implemented method for pelvic floor feedback. The method includes capturing a strength of action potentials via wireless sensors, the wireless sensors positioned proximate to a pelvic floor of a user. The method also includes transmitting the strength of the action potentials to a mobile device. The method also includes recording the strength of the action potentials on the mobile device.
Type:
Application
Filed:
August 29, 2022
Publication date:
May 4, 2023
Applicant:
Cornell University
Inventors:
Jeremy B. WIYGUL, Saie Milind GANOO, Rohit CURUCUNDHI
Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
Abstract: The present invention is directed to transduced T cells expressing at least 100,000 molecules of human somatostatin receptor 2 (SSTR2), which improves PET/CT imaging sensitivity. The present invention is also directed to transduced T cells expressing SSTR2 and chimeric antigen receptor (CAR). In one embodiment, the CAR is specific to human ICAM-1 and the CAR comprises a binding domain that is scFv of anti-human ICAM-1, or an I domain of the ?L subunit of human lymphocyte function-associated antigen-1. In another embodiment, the CAR is specific to human CD19, and the CAR comprises a binding domain that is scFv of anti-human CD19. The present invention is further directed to using the above transduced T cells for monitoring T cell distribution in a patient by PET/CT imaging and/or treating cancer.
Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
Type:
Grant
Filed:
February 15, 2021
Date of Patent:
April 25, 2023
Assignee:
Cornell University
Inventors:
Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
Abstract: The present application provides methods and systems for detecting and quantifying chromosomal instability from histology images with machine learning. Also described herein are methods for selecting treatments for a medical disease, by determining a chromosomal instability pathological metric from histology images. The disclosed methods and systems may also be used to investigate disease progression and prognosis.
Type:
Application
Filed:
September 21, 2022
Publication date:
April 20, 2023
Applicants:
Volastra Therapeutics, Inc., Center for Technology Licensing at Cornell University (CTL)
Abstract: The present disclosure relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in a plant cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that comprises a DNA binding domain comprising one or more Transcription Activator-Like (TAL) effector monomers specifically ordered to target the genomic locus of interest to improve tolerance of the plant cell to an effective concentration of an inhibitor herbicide.
Type:
Grant
Filed:
April 19, 2017
Date of Patent:
April 11, 2023
Assignees:
BASF Agricultural Solutions Seed US LLC, Cornell University
Inventors:
Manuel Dubald, Alain Sailland, Yueh-Jiang Hwang, Apurva Bhargava, Adam Bogdanove, Fabio Rinaldi
Abstract: The present invention provides a method for removing re-sputtered material on a substrate. A process chamber having a plasma source and a substrate support is provided along with the substrate having an upper surface and a lower surface. A masking material having a patterned sidewall is patterned onto the upper surface of the substrate along with a sacrificial layer between the upper surface of the substrate and the masking material. The lower surface of the substrate is placed onto the substrate support. A plasma is generated using the plasma source. The substrate is processed on the substrate support using the generated plasma. The sacrificial layer is removed after the processing of the substrate.
Type:
Grant
Filed:
December 2, 2020
Date of Patent:
March 28, 2023
Assignee:
Cornell University
Inventors:
David G. Lishan, Kyle Dorsey, Vincent J. Genova
Abstract: A waveguide is provided. The waveguide having a first core, a second core spaced apart from and parallel with the first core, and a cladding surrounding the first core and the second core. An interstitial portion of the cladding is located between the first core and the second core. A first region of the first core adjacent to the cladding or of the cladding adjacent to the first core is color dyed.
Type:
Grant
Filed:
November 29, 2018
Date of Patent:
March 28, 2023
Assignee:
Cornell University
Inventors:
Robert Shepherd, Hedan Bai, Shuo Li, Yaqi Tu
Abstract: The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide.
Type:
Application
Filed:
February 25, 2022
Publication date:
March 9, 2023
Applicants:
Cornell University, University of Florida Research Foundation
Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The processing device is configured to obtain time-series temperature data from respective temperature sensors arranged at respective different subsurface depths, and for each of a plurality of pairs of the temperature sensors, to compute a cross-correlation of their corresponding time-series temperature data, to compute a time derivative of the cross-correlation, and to generate an estimate of at least one reservoir property based at least in part on the time derivative of the cross-correlation. At least one automated action is performed based at least in part on the generated estimate, such as, for example, controlling an amount of fluid flow into or out of a particular subsurface region. The generated estimates illustratively comprise estimates of subsurface hydraulic diffusivity.
Type:
Grant
Filed:
September 8, 2020
Date of Patent:
February 28, 2023
Assignees:
Cornell University, The Regents of the University of California
Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.
Type:
Application
Filed:
November 3, 2022
Publication date:
February 23, 2023
Applicant:
Cornell University
Inventors:
Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
Abstract: The present disclosure relates to a systemically administered peptide delivery platform that biodistributes to the kidney or urinary tract. The disclosure further relates to methods of treating a disease of the kidney or urinary tract in a subject in need thereof.
Type:
Grant
Filed:
December 20, 2021
Date of Patent:
February 7, 2023
Assignees:
Cornell University, Tu Therapeutics Inc.
Inventors:
Shek Hang Benedict Law, Vanessa Bellat, Benjamin Byung-min Choi
Abstract: Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.
Type:
Grant
Filed:
November 1, 2021
Date of Patent:
February 7, 2023
Assignees:
Samsung Electronics Co., Ltd., The University of Chicago, Center for Technology Licensing at Cornell University
Abstract: The present disclosure relates to methods and compositions for elevating and stabilizing retromer for treating and/or preventing Alzheimer's disease and other neurodegenerative disorders. Additionally, the disclosure relates to adenoviral based therapy for treating Alzheimer's disease (AD), and other neurodegenerative conditions such as Parkinson's Disease (PD), neuronal ceroid lipofuscinosis (NCL), and transmissible spongiform encephalopathies (TSEs or prion disease), multiple system atrophy (MSA), Down's syndrome, and hereditary spastic paraplegia, as well as tauopathies such as progressive supranuclear palsy (PSP), frontotemporal lobar dementia linked to chromosome 17q21-22 and its subtypes (FTLD-17/FTLD-Tau), Lewy Body Disease (LBD), amyotrophic lateral sclerosis (ALS), frontal-temporal degeneration (FTD), ALS-FTD, and chronic traumatic encephalopathy (CTE).
Type:
Application
Filed:
December 7, 2020
Publication date:
January 26, 2023
Applicants:
The Trustees of Columbia University in the City of New York, Cornell University, Meiragtx UK II Limited
Inventors:
Scott A. SMALL, Gregory PETSKO, Rebecca COX, Samuel D. WAKSAL, Alexandria FORBES, Yasir H. QURESHI
Abstract: Described herein are nanoprobes comprising ultrasmall aminated and cRGDY-conjugated nanoparticles labeled with Zirconium-89 (89Zr) and methods of their use. The provided compositions are renally clearable and possess suitable blood circulation half-time, high tumor active targeting capability, dominant renal clearance, low liver accumulation, and a high tumor-to-background ratio. The described nanoprobes exhibit great potential as “target-or-clear” tracers to human subjects for systemic targeted imaging (or treatment) of cancer.
Type:
Grant
Filed:
May 17, 2018
Date of Patent:
January 24, 2023
Assignees:
Memorial Sloan Kettering Cancer Center, Cornell University
Inventors:
Michelle S. Bradbury, Feng Chen, Ulrich Wiesner, Kai Ma
Abstract: The present disclosure relates to methods for producing hydrogen and calcium- or magnesium-bearing carbonates by capturing, converting, and storing carbon dioxide. The methods may include providing one or more calcium- or magnesium-bearing compounds; providing one or more water-soluble oxygenates; providing a plurality of catalysts; and reacting one or more calcium- or magnesium-bearing compounds and one or more water-soluble oxygenates with plurality of catalysts under conditions to produce hydrogen and calcium- or magnesium-bearing carbonates. The methods may include providing one or more calcium- or magnesium-bearing silicates; providing carbon monoxide; providing water vapor; and reacting one or more calcium- or magnesium-bearing silicates, carbon monoxide, and water vapor.
Abstract: A new and distinct variety of apple tree rootstock Malus domestica x Malus robusta hybrid ‘G.257’ is described. The new variety is a semi-dwarfing rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum) and tolerant to the replant disease complex. The ‘G.257’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.
Type:
Grant
Filed:
January 31, 2022
Date of Patent:
March 7, 2023
Assignees:
Cornell University, The United States of America, as Represented by the Secretary of Agriculture
Inventors:
Gennaro Fazio, Terence Lee Robinson, Herbert Sanders Aldwinckle, James N. Cummins
Abstract: A new and distinct variety of apple tree rootstock Malus hybrid ‘G.484’ is described herein. The new variety is a dwarfing, precocious and productive rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum). The ‘G.484’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.
Type:
Grant
Filed:
January 31, 2022
Date of Patent:
March 21, 2023
Assignees:
Cornell University, The United States of America, as Represented by the Secretary of Agriculture
Inventors:
Gennaro Fazio, Terence Lee Robinson, Herbert Sanders Aldwinckle, James Cummins