Patents Assigned to Cornell Research Foundation
  • Patent number: 11913021
    Abstract: The present invention relates to adenovirus E4ORF1 gene and to endothelial cells engineered to express the E4ORF1 gene. The present invention also relates to uses of the E4ORF1 gene, and cells expressing the E4ORF1 gene, and to compositions comprising the E4ORF1 gene, or comprising cells expressing the E4ORF1 gene.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: February 27, 2024
    Assignees: Cornell Research Foundation, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Shahin Rafii, Fan Zhang, Marco Seandel
  • Patent number: 11865172
    Abstract: The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: January 9, 2024
    Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., CORNELL RESEARCH FOUNDATION, INC., THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION
    Inventors: Patti Cynthia Crawford, Paul J. Gibbs, Edward J. Dubovi, Ruben Omar Donis, Jacqueline Katz, Alexander I. Klimov, Nallakannu P. Lakshmanan, Melissa Anne Lum, Daniel Ghislena Emiel Goovaerts, Mark William Mellencamp, Nancy J. Cox, William L. Castleman
  • Patent number: 11845807
    Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
    Type: Grant
    Filed: November 8, 2021
    Date of Patent: December 19, 2023
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Hazel H. Szeto, Kesheng Zhao, Hugh Robertson, Alex V. Birk
  • Publication number: 20230293624
    Abstract: The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
    Type: Application
    Filed: February 10, 2022
    Publication date: September 21, 2023
    Applicants: Cornell Research Foundation, Inc., Institut De Recherches Cliniques De Montreal
    Inventors: Hazel H. Szeto, Peter W. Schiller, Kesheng Zhao
  • Patent number: 11753666
    Abstract: The present invention relates to a system for production of ATP. This system is comprised of a support and one or more enzymes coupled to that support which are capable of collectively producing ATP from glucose or fructose metabolism. The present invention is additionally directed to a device, which includes the system, and to a method for carrying out a reaction involving the conversion of ATP to ADP using the system.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: September 12, 2023
    Assignee: CORNELL RESEARCH FOUNDATION, INC.
    Inventor: Alexander Travis
  • Publication number: 20230212220
    Abstract: The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
    Type: Application
    Filed: August 3, 2022
    Publication date: July 6, 2023
    Applicant: Cornell Research Foundation, Inc.
    Inventors: Hazel H. Szeto, Shaoyi Liu, Sunghee Cho
  • Publication number: 20230149501
    Abstract: The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids, (d) a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 3a or 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1; and (f) at least one tyrosine or tryptophan amino acid.
    Type: Application
    Filed: October 4, 2021
    Publication date: May 18, 2023
    Applicant: Cornell Research Foundation, Inc.
    Inventor: Hazel H. Szeto
  • Publication number: 20220372172
    Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
    Type: Application
    Filed: November 8, 2021
    Publication date: November 24, 2022
    Applicant: Cornell Research Foundation, Inc.
    Inventors: Hazel H. Szeto, Kesheng Zhao, Hugh Robertson, Alex V. Birk
  • Patent number: 11472100
    Abstract: The present invention relates to an article fabrication system having a plurality of material deposition tools containing one or more materials useful in fabricating the article, and a material deposition device having a tool interface for receiving one of the material deposition tools. A system controller is operably connected to the material deposition device to control operation of the material deposition device. Also disclosed is a method of fabricating an article using the system of the invention and a method of fabricating a living three-dimensional structure.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: October 18, 2022
    Assignee: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: Lawrence Bonassar, Hod Lipson, Daniel L. Cohen, Evan Malone
  • Patent number: 11447523
    Abstract: The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: September 20, 2022
    Assignee: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: Hazel H. Szeto, Shaoyi Liu, Sunghee Cho
  • Patent number: 11180574
    Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: November 23, 2021
    Assignee: CORNELL RESEARCH FOUNDATION INC.
    Inventors: Hazel H. Szeto, Kesheng Zhao, Hugh Robertson, Alex V. Birk
  • Patent number: 11160859
    Abstract: The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: November 2, 2021
    Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., CORNELL RESEARCH FOUNDATION, INC., THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION
    Inventors: Patti Cynthia Crawford, Paul J. Gibbs, Edward J. Dubovi, Ruben Omar Donis, Jacqueline Katz, Alexander I. Klimov, Nallakannu P. Lakshmanan, Melissa Anne Lum, Daniel Ghislena Emiel Goovaerts, Mark William Mellencamp, Nancy J. Cox, William L. Castleman
  • Publication number: 20210155899
    Abstract: The present invention relates to adenovirus E4ORF1 gene and to endothelial cells engineered to express the E4ORF1 gene. The present invention also relates to uses of the E4ORF1 gene, and cells expressing the E4ORF1 gene, and to compositions comprising the E4ORF1 gene, or comprising cells expressing the E4ORF1 gene.
    Type: Application
    Filed: November 16, 2020
    Publication date: May 27, 2021
    Applicants: Cornell Research Foundation, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Shahin RAFII, Fan ZHANG, Marco SEANDEL
  • Publication number: 20210047369
    Abstract: The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
    Type: Application
    Filed: April 2, 2020
    Publication date: February 18, 2021
    Applicant: Cornell Research Foundation, Inc.
    Inventors: Hazel H. Szeto, Shaoyi Liu, Sunghee Cho
  • Publication number: 20210015887
    Abstract: The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids, (d) a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 3a or 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1; and (f) at least one tyrosine or tryptophan amino acid.
    Type: Application
    Filed: February 21, 2020
    Publication date: January 21, 2021
    Applicant: Cornell Research Foundation, Inc.
    Inventor: Hazel H. Szeto
  • Patent number: 10865379
    Abstract: The present invention relates to adenovirus E4ORF1 gene and to endothelial cells engineered to express the E4ORF1 gene. The present invention also relates to uses of the E4ORF1 gene, and cells expressing the E4ORF1 gene, and to compositions comprising the E4ORF1 gene, or comprising cells expressing the E4ORF1 gene.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: December 15, 2020
    Assignees: Cornell Research Foundation, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Shahin Rafii, Fan Zhang, Marco Seandel
  • Publication number: 20200299415
    Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
    Type: Application
    Filed: February 20, 2020
    Publication date: September 24, 2020
    Applicant: Cornell Research Foundation, Inc.
    Inventors: Hazel H. Szeto, Kesheng Zhao, Hugh Robertson, Alex V. Birk
  • Patent number: 10695466
    Abstract: The present invention relates to an article fabrication system having a plurality of material deposition tools containing one or more materials useful in fabricating the article, and a material deposition device having a tool interface for receiving one of the material deposition tools. A system controller is operably connected to the material deposition device to control operation of the material deposition device. Also disclosed is a method of fabricating an article using the system of the invention and a method of fabricating a living three-dimensional structure.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: June 30, 2020
    Assignee: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: Lawrence Bonassar, Hod Lipson, Daniel L. Cohen, Evan Malone
  • Patent number: 10636093
    Abstract: A method and system for valuing structured-finance securities, such as, but not limited to, commercial mortgage-backed securities (CMBS).
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: April 28, 2020
    Assignees: CORNELL RESEARCH FOUNDATION, INC., WOTN, LLC
    Inventors: Andreas D. Christopolous, Robert A. Jarrow, Joshua G. Barratt, Shirish Chinchalkar, Thomas F. Coleman, Abram Connelly, Daniel C. Ilut, Tibor Janosi, Yohan Kim, Yildiray Yildirim, Mark A. Zifchock
  • Patent number: 10612092
    Abstract: A method for assessing risk of losing a transplanted organ by a patient having an episode of acute rejection of the transplanted organ is described. The method includes obtaining from the patient a cell sample from the transplanted organ or peripheral blood, determining a level of FOXP3 in the cell sample, and correlating the level with the risk of loss of the transplanted organ, wherein, compared to a control level, a significantly greater level of FOXP3 in the cell sample from the transplanted organ or a significantly lower level of FOXP3 in the cell sample from the peripheral blood correlates with a decreased risk of loss of the transplanted organ.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: April 7, 2020
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Manikkam Suthanthiran