Abstract: The present disclosure provides a conjugate comprising an affinity agent, a branched linker, and two or more photoisomerizable regulators. The present disclosure provides compositions comprising the conjugate, as well as devices comprising the compositions. The present disclosure provides methods for enhancing visual function, the methods comprising administering the conjugate to an individual in need thereof.
Type:
Grant
Filed:
May 27, 2021
Date of Patent:
September 3, 2024
Assignees:
Cornell Univerisity, MAX-PLANCK-GESELLSCHAFT ZUR FĂ–RDERUNG DER WISSENSCHAFTEN E.V., The Regents of the University of California
Inventors:
Ehud Y. Isacoff, Johannes Broichhagen, Joshua T. Levitz
Abstract: This invention relates to pharmaceutical composition and methods of using vitamin A and/or RAR? agonist for the treatment or prevention of diseases or conditions associated with high fat diet and/or vitamin deficiency.
Type:
Grant
Filed:
November 8, 2019
Date of Patent:
December 28, 2021
Assignee:
CORNELL UNIVERISITY
Inventors:
Lorraine J Gudas, Yannick Benoit, Ronald Perez, Xiao-Han Tang, Steven Trasino