Abstract: The present invention provides a dynamic interface system between an extraction device and a chromatographic purification device for separating and purifying substance(s) from a mixture or matrix. One embodiment is the Supercritical Fluid Interface (“SFI”) between Supercritical Fluid Extraction (“SFE”), and Supercritical Fluid Chromatography (“SFC”). The SFI is capable of interfacing; gas, subcritical and supercritical fluid extraction methods and pair with gas, subcritical and supercritical fluid chromatography technologies that operate within the pressure and temperature parameters of the SFI. The SFI can operate up to 200 degrees celsius and 5000 psi.

Abstract: The present invention provides a dynamic interface system between an extraction device and a chromatographic purification device for separating and purifying substance(s) from a mixture or matrix. One embodiment is the Supercritical Fluid Interface (“SFI”) between Supercritical Fluid Extraction (“SFE”), and Supercritical Fluid Chromatography (“SFC”). The SFI is capable of interfacing; gas, subcritical and supercritical fluid extraction methods and pair with gas, subcritical and supercritical fluid chromatography technologies that operate within the pressure and temperature parameters of the SFI. The SFI can operate up to 200 degrees celsius and 5000 psi.

Abstract: A method for creating ultra-fine particles of material using a high-pressure mill is described. The method includes placing a material in a first chamber and subjecting the material to a high-pressure liquid jet to divide it into particles. These particles are then transferred to a second chamber in which they are subjected to cavitation to further divide the particles into relatively smaller particles. These relatively smaller particles are then transferred to a third chamber, in which the particles collide with a collider to still further divide them into ultra-fine particles of the material. The mill of the present invention includes a first chamber having an high-pressure liquid jet nozzle, first and second slurry nozzles, a second cavitation chamber and a third chamber which houses a collider. Sensors may be located throughout the mill to collect data on the comminution process and to use the data to control the resultant particle size.