Patents Assigned to Cornerstone Therapeutics, Inc.
  • USE OF ZILEUTON FOR THE TREATMENT OF NASAL POLYPS IN CYSTIC FIBROSIS PATIENTS
    Publication number: 20140323446
    Abstract: The present invention provides methods of treating nasal polyps in cystic fibrosis patients using zileuton. The present invention also provides methods of treating nasal polyps in cystic fibrosis patients using zileuton in combination with surgical debridement and/or steroid treatment.
    Type: Application
    Filed: August 23, 2012
    Publication date: October 30, 2014
    Applicant: CORNERSTONE THERAPEUTICS INC.
    Inventors: Joseph K. Han, Carmen Dell'Anna
  • Piperazines, pharmaceutical compositions and methods of use thereof
    Patent number: 8822472
    Abstract: Disclosed are novel piperazine derivatives that act as agonists of the ?7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: September 2, 2014
    Assignee: Cornerstone Therapeutics, Inc.
    Inventors: Roger B. Clark, Daniel Elbaum
  • Novel Piperazines, Pharmaceutical Compositions and Methods of Use Thereof
    Publication number: 20120071652
    Abstract: Disclosed are novel piperazine derivatives that act as agonists of the ?7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
    Type: Application
    Filed: March 23, 2011
    Publication date: March 22, 2012
    Applicant: CORNERSTONE THERAPEUTICS, INC.
    Inventors: Roger B. Clark, Daniel Elbaum
  • Anabaseine derivatives, pharmaceutical compositions and methods of use thereof
    Patent number: 8008499
    Abstract: Disclosed are novel anabaseine derivatives that act as agonists of the ?7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: August 30, 2011
    Assignee: Cornerstone Therapeutics, Inc.
    Inventors: Gregory J. Habgood, Daniel Elbaum
  • Crystal form and pharmaceutical compositions of (+)-R-zileuton
    Patent number: 8003684
    Abstract: Crystalline forms of (+)-R-zileuton, which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of (+)-R-zileuton are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline (+)-R-zileuton, and using it to inhibit 5-lipoxygenase activity in subjects to treat a number of diseases, are also discussed.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: August 23, 2011
    Assignee: Cornerstone Therapeutics, Inc.
    Inventor: Jason A. Hanko
  • Piperazines, pharmaceutical compositions and methods of use thereof
    Patent number: 7943622
    Abstract: Disclosed are novel piperazine derivatives that act as agonists of the ?7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: May 17, 2011
    Assignee: Cornerstone Therapeutics, Inc.
    Inventors: Roger B. Clark, Daniel Elbaum
  • NOVEL ANABASEINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20100311773
    Abstract: Disclosed are novel anabaseine derivatives that act as agonists of the ?7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
    Type: Application
    Filed: December 30, 2009
    Publication date: December 9, 2010
    Applicant: Cornerstone Therapeutic, Inc.
    Inventors: Gregory J. Habgood, Daniel Elbaum
  • Anabaseine derivatives, pharmaceutical compositions and method of use thereof
    Patent number: 7662965
    Abstract: Disclosed are novel anabaseine derivatives that act as agonists of the ?7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: February 16, 2010
    Assignee: Cornerstone Therapeutics, Inc.
    Inventors: Gregory J. Habgood, Daniel Elbaum
  • Monoclonal antibodies against HMGB1
    Patent number: 7632500
    Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: December 15, 2009
    Assignee: Cornerstone Therapeutics, Inc.
    Inventors: Walter Newman, Shixin Qin, Theresa L. O'Keefe, Robert A. Obar