Patents Assigned to CorNova, Inc.
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Patent number: 9113785Abstract: Systems, methods, and apparatus for providing a fluid and reduced-toxicity optical media with optical analysis and therapeutic energy delivery. An aspect of the invention provides an aqueous solution of increased-salinity of between about 1% and 35%. An increasing salinity in accordance with the invention provides improved transmissive efficiency at many wavelengths and less toxicity than many existing systems and methods. A catheter having integrated fibers for probing or treating internal lumens or other tissues can include a liquid-inflatable balloon or flushing mechanism using the solution for displacing blood or other obstructions in an optical path between the fiber and targeted tissue. Methods including spectroscopy can be employed with the solution for diagnosing medical conditions associated with diseased vessels or other tissues while reducing the risk of permanent damage resulting from the diagnosis.Type: GrantFiled: December 21, 2007Date of Patent: August 25, 2015Assignee: CORNOVA, INC.Inventors: S. Eric Ryan, Jing Tang, Matthew Flinders
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Publication number: 20140005553Abstract: A system is provided for probing a body lumen that includes a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit. A spectrometer is connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform spectroscopy. A controller system is configured to calculate a distance between the flexible conduit and the wall of the body lumen based on a spectroscopic measurement of the at least one primary radiation signal that traveled between the flexible conduit and body lumen.Type: ApplicationFiled: September 21, 2011Publication date: January 2, 2014Applicant: CORNOVA, INC.Inventors: S. Eric Ryan, Jing Tang, Richard Gambale
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Publication number: 20120330166Abstract: Systems and methods are provided for probing an occluded body lumen, including a flexible conduit insertable into the body lumen, at least one delivery waveguide and at least one collection waveguide integrated with the flexible conduit and arranged to deliver and collect radiation about a distal end of said flexible conduit, at least one radiation source connected to a transmission input of the at least one delivery waveguide, at least one optical detector connected to a transmission output of at least one collection waveguide, a spectrometer connected with the at least one optical detector, and constructed and arranged to scan radiation and perform spectroscopy, and a controller programmed to process data from said spectrometer and provide information for directing said flexible conduit through obstacles within the occluded body lumen.Type: ApplicationFiled: August 31, 2012Publication date: December 27, 2012Applicant: CORNOVA, INC.Inventor: Jing Tang
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Publication number: 20120078121Abstract: A catheter for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon; and, at least one elongate arm connected to the conduit and positioned within the balloon, the at least one elongate arm radially translatable with respect to the conduit, and wherein at least one of the transmission output and transmission input is coupled to the elongate arm.Type: ApplicationFiled: May 20, 2010Publication date: March 29, 2012Applicant: CorNova, Inc.Inventors: S. Eric Ryan, Jing Tang, Richard Gambale
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Publication number: 20110054592Abstract: A flexible, expandable stent assembly comprises a pattern of interconnected struts along a curvilinear path. The struts define a cylindrically shaped channel that extends along a longitudinal axis. The channel has a plurality of openings. The struts comprise a plurality of circumferential arrays of webs or bends. Each circumferential array is connected to an adjacent circumferential array by fewer than four cross-links. Each cross-link extending from a first side of a circumferential array of the plurality of circumferential arrays is substantially circumferentially offset from every cross-link extending from an opposite side of the same circumferential array. Each of the struts has, in a cross-section generally normal to the curvilinear path of the strut and normal to a center of curvature of the channel, a strut surface width that is at least one and a half times that of a strut surface height of the strut.Type: ApplicationFiled: December 10, 2008Publication date: March 3, 2011Applicant: CORNOVA, INC.Inventor: Thilo U. Fliedner
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Publication number: 20100286531Abstract: A system for analyzing a body lumen including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end; at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit; a spectrometer connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform diffuse reflectance spectroscopy, wherein the spectrometer emits at least one primary radiation signal of a wavelength having an absorption coefficient of between about 8 cm?1 and about 10 cm?1 when transmitted through a highly aqueous media; a controller system configured to calculate at least one of an extent, area, and volume of highly aqueous media based on the amount of absorption of the at least one primary radiatioType: ApplicationFiled: May 20, 2010Publication date: November 11, 2010Applicant: CorNova, Inc.Inventors: S. Eric Ryan, Jing Tang, Richard Gambale
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Publication number: 20100204780Abstract: Stent strut and surface geometries are provided for enhancing surface coating applications while providing highly beneficial biomechanical properties. A low-profile, flexible, expandable, elongated, stent assembly is provided and defined by a structure of connected circumferential arrays of webs or bends, the webs or bends and their connections having limited degrees of curvature that help avoid interference during various surface-modifying and surface-enhancing processes.Type: ApplicationFiled: September 26, 2008Publication date: August 12, 2010Applicant: CorNova, Inc.Inventors: Thilo U. Fliedner, Eric S. Ryan
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Publication number: 20100174196Abstract: A system for treating a body lumen comprises a catheter including a flexible conduit that is elongated along a longitudinal axis and suitable for insertion into a body lumen, the conduit having a proximal end and a distal end, one or more waveguides integrated with the flexible conduit, the one or more waveguides constructed and arranged to deliver and collect radiation concentrated along a predetermined radial axis of the conduit, the predetermined radial axis of the conduit substantially aligned with respect to at least one therapy delivery component of the catheter, at least one radiation source connected to a transmission input of the one or more waveguides integrated with the flexible conduit, and at least one optical detector connected to a transmission output of the one or more waveguides integrated with the flexible conduit.Type: ApplicationFiled: June 20, 2008Publication date: July 8, 2010Applicant: CORNOVA, INC.Inventors: S. Eric Ryan, Jing Tang
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Publication number: 20100104880Abstract: Biodurable, biocompatible polymers for coating applications and tie-coat polymers especially useful in tie-coat applications as an intermediate layer between two other layers or coatings or between a surface and a coating applied to that surface are disclosed, together with methods for preparing such biocompatible polymers and tie-coat polymers, methods for using such biocompatible polymers and tie-coat polymers, and products that use or incorporate such biocompatible polymers and tie-coat polymers. The biocompatible polymers generally comprise polyurethane polymers having polycarbonate backbones, and the tie-coat polymers useful with these biocompatible polymers generally comprise polyurea or polyurethane-polyurea polymers.Type: ApplicationFiled: February 13, 2008Publication date: April 29, 2010Applicant: CORNOVA, INC.Inventor: Harold E. Garey
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Publication number: 20100094109Abstract: Systems and methods are provided for probing an occluded body lumen, including a flexible conduit insertable into the body lumen, at least one delivery waveguide and at least one collection waveguide integrated with the flexible conduit and arranged to deliver and collect radiation about a distal end of said flexible conduit, at least one radiation source connected to a transmission input of the at least one delivery waveguide, at least one optical detector connected to a transmission output of at least one collection waveguide, a spectrometer connected with the at least one optical detector, and constructed and arranged to scan radiation and perform spectroscopy, and a controller programmed to process data from said spectrometer and provide information for directing said flexible conduit through obstacles within the occluded body lumen.Type: ApplicationFiled: October 15, 2009Publication date: April 15, 2010Applicant: CORNOVA, INC.Inventor: Jing Tang
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Publication number: 20100069760Abstract: A method and apparatus for analyzing and treating internal lumens is provided. The apparatus includes a catheterized device integrating an optical probe and local treatment delivery system. The probe component includes fiber optic lines that can be used in conjunction with visible and/or near infrared spectroscopy to analyze various characteristics of tissues, including chemical, blood, and oxygen content, in order to locate those tissues associated with diseased lumens, to determine the best location for applying treatment, and to monitor treatment and its effects. Physically integrated with the probe component is a treatment component for delivering localized treatments including stem cells, antibiotics, gene therapy, neoplasty, and sclerosant drugs, etc. A control system coordinates operation of the catheter, including performing chemometric analysis with the use of model data, and for providing control and visual feedback to an operator.Type: ApplicationFiled: September 17, 2009Publication date: March 18, 2010Applicant: CorNova, Inc.Inventor: Jing Tang
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Publication number: 20100049182Abstract: Systems, methods, and apparatus for providing a fluid and reduced-toxicity optical media with optical analysis and therapeutic energy delivery. An aspect of the invention provides an aqueous solution of increased-salinity of between about 1% and 35%. An increasing salinity in accordance with the invention provides improved transmissive efficiency at many wavelengths and less toxicity than many existing systems and methods. A catheter having integrated fibers for probing or treating internal lumens or other tissues can include a liquid-inflatable balloon or flushing mechanism using the solution for displacing blood or other obstructions in an optical path between the fiber and targeted tissue. Methods including spectroscopy can be employed with the solution for diagnosing medical conditions associated with diseased vessels or other tissues while reducing the risk of permanent damage resulting from the diagnosis.Type: ApplicationFiled: December 21, 2007Publication date: February 25, 2010Applicant: CORNOVA, INC.Inventors: S. Eric Ryan, Jing Tang, Matthew Flinders
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Publication number: 20090227993Abstract: An optical fiber tip comprises a core and a recess formed in said core at a distal end of the optical fiber tip, said recess having a vertex within said core.Type: ApplicationFiled: May 15, 2009Publication date: September 10, 2009Applicant: CORNOVA, INC.Inventor: JING TANG
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Publication number: 20090187108Abstract: A catheter is provided for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end. The catheter further includes at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers.Type: ApplicationFiled: January 8, 2009Publication date: July 23, 2009Applicant: CORNOVA, INC.Inventors: Jing Tang, S. Eric Ryan
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Publication number: 20090175576Abstract: An optical fiber tip comprises a core and a recess formed in said core at a distal end of the optical fiber tip, said recess having a vertex within said core.Type: ApplicationFiled: January 8, 2009Publication date: July 9, 2009Applicant: CORNOVA, INC.Inventor: Jing Tang
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Publication number: 20080215132Abstract: Textured coatings for implantable medical devices can be provided in metallic or polymer surface layers having surface texture factors down to nanometer and sub-nanometer levels. Implantable devices having such textured surfaces and methods of coating such devices comprises providing a substrate surface of an implantable device and forming a coating layer of the substrate surface by directing a mixture of atoms of a first type of material and a second type of material toward the substrate surface while simultaneously and collinearly bombarding the substrate surface with ions, wherein the first type of material is substantially resistant to a removal process and the second type of material is substantially susceptible to a removal process.Type: ApplicationFiled: August 22, 2007Publication date: September 4, 2008Applicant: CORNOVA, INC.Inventors: S. Eric Ryan, Richard Sahagian
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Publication number: 20080177371Abstract: An implantable device and method of forming the same comprises a substrate, an adhesion layer, and a capping layer. The adhesion layer comprises a portion with a predominant proportion of palladium, the portion of the predominant proportion of palladium directly on the substrate. The capping layer comprises a capping layer material, and is on the adhesion layer.Type: ApplicationFiled: August 22, 2007Publication date: July 24, 2008Applicant: CorNova, Inc.Inventors: S. Eric Ryan, Richard Sahagian
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Publication number: 20080125634Abstract: A method and apparatus for analyzing and treating internal tissues and, in particular, tissues affected by myocardial infarct. The apparatus includes a catheterized device integrating an optical probe and treatment delivery system. The probe component includes fiber optic lines that can be used in conjunction with infrared spectroscopy to analyze various characteristics of tissues, including chemical, blood, and oxygen content, in order to locate those tissues associated with myocardial infarct, to determine the best location for applying treatment, and to monitor treatment and its effects. Physically integrated with the probe component is a treatment component for delivering treatments including stem cell and gene therapy, known for having beneficial effects on tissues associated with myocardial infarct. A control system coordinates operation of the catheter, including performing chemometric analysis with the use of model data, and for providing control and visual feedback to an operator.Type: ApplicationFiled: June 14, 2007Publication date: May 29, 2008Applicant: CORNOVA, INC.Inventors: S. Eric Ryan, Jing Tang
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Publication number: 20070270717Abstract: A reflecting element with multiple reflective facets is integrated with the distal end of a multi-fiber optical probe. The facets are shaped depending on the type of analysis performed and according to the desired distribution of radiation to and from internal body tissues and fluids. The probe can include a protective transparent balloon or other covering that separates the reflecting element from interior tissue walls and provides a window for radiation to be transmitted between the reflecting facets and a region of interest. The probe can be integrated with treatment-based devices, including lumen-expanding angioplasty balloon catheters. The probe can also be adapted as an imaging device such as an endoscope.Type: ApplicationFiled: August 6, 2007Publication date: November 22, 2007Applicant: CORNOVA, INC.Inventors: Jing Tang, Timothy Looney, S. Ryan
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Patent number: D553747Type: GrantFiled: January 25, 2006Date of Patent: October 23, 2007Assignee: CorNova, Inc.Inventor: Thilo U Fliedner