Abstract: Various cutting devices and systems are described that excise and/or incise tissue from a target site. For example, the wall of an artery and/or adventitial to the artery wall from inside the artery. According to embodiments of the invention, a lateral incision catheter device configured to be introduced intra-luminally to a pre-selected site in the body is provided, generally including a rotating first catheter, including a proximal end, a distal end and lumen positioned therebetween; a first shell to a first rotating catheter and having a cutting surface; a second shell attached to a second catheter, whereby rotation of the first rotating catheter causes the first shell to rotate with respect to the second shell so as to permit the cutting surface to cut tissue at the pre-selected site.