Patents Assigned to CorTechs
  • Bradykinin receptor antagonists with neurokinin receptor blocking activity
    Patent number: 5610140
    Abstract: The present invention provides a heterodimeric compound possessing bradykinin and neurokinin receptor antagonist activities useful in the treatment of asthma and other inflammatory diseases especially those involving the airway or pulmonary system. The present invention is also useful in the treatment of pain and inflammation.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: March 11, 1997
    Assignee: Cortech, Inc.
    Inventors: Val S. Goodfellow, Eric T. Whalley, Francine E. Wincott
  • Bradykinin antagonists
    Patent number: 5416191
    Abstract: A bradykinin antagonist of the formulaX(BKA).sub.nwherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonists of the formula X(BKA) are also disclosed.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: May 16, 1995
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, Eric T. Whalley, Khe T. Nguyen, Shadrach R. Eubanks, Lisa G. Allen
  • Ester inhibitors
    Patent number: 5314910
    Abstract: 2-Heteroaromatic alkanoate esters which are useful as inhibitors of human leukocyate or neutrophil elastase.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: May 24, 1994
    Assignee: Cortech Inc.
    Inventors: Gary P. Kirschenheuter, Raymond T. Cunningham, John C. Cheronis
  • N-succinimidyl and N-phthalimidyl esters of 2-phenylalkanoic acid derivatives as inhibitors of human leukocyte elastase
    Patent number: 5281617
    Abstract: N-succinimidyl and N-phthalimidyl esters of phenylalkanoic acid derivatives which are useful as inhibitors of HLE or HNE.
    Type: Grant
    Filed: February 5, 1993
    Date of Patent: January 25, 1994
    Assignee: Cortech, Inc.
    Inventors: Gary P. Kirschenheuter, John C. Cheronis
  • Ester inhibitors
    Patent number: 5240956
    Abstract: 2-Heteroaromatic alkanoate esters which are useful as inhibitors of human leukocyate or neutrophil elastase.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: August 31, 1993
    Assignee: Cortech, Inc.
    Inventors: Gary P. Kirschenheuter, Raymond T. Cunningham, John C. Cheronis
  • Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase
    Patent number: 5216022
    Abstract: Compounds of the formula ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or together represent methylene groups --(CH.sub.2).sub.n --where n is a whole number from 1 to 6, provided that R.sub.1 and R.sub.2 or R.sub.3 and R.sub.4 are not both hydrogen;R.sub.5 and R.sub.6, which may be the same or different, are selected from the group consisting of hydrogen, halogen, nitro or --S(O).sub.n R.sub.7 where n is 0, 1 or 2 and R.sub.7 is an optionally substituted alkyl of 1-12 carbons atoms; and both Ar substituents are optionally substituted heteroaromatic rings or one Ar is such heteroaromatic ring and the other is optionally substituted phenyl, the optional substitution for Ar being halogen, nitro or --S(O).sub.n R.sub.7 where n and R.sub.7 have the value given above. The compounds are useful as inhibitors of human neutrophil elastase.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: June 1, 1993
    Assignee: Cortech, Inc.
    Inventors: Jozef Oleksyszyn, Gary P. Kirschenheuter
  • Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase
    Patent number: 5214191
    Abstract: 2-Phenylalkanoate esters which are useful as inhibitors of human leukocyte elastase.
    Type: Grant
    Filed: May 22, 1990
    Date of Patent: May 25, 1993
    Assignee: Cortech, Inc.
    Inventors: Gary P. Kirschenheuter, Lyle W. Spruce, John C. Cheronis