Patents Assigned to Cortendo AB
  • Patent number: 9918984
    Abstract: Pharmaceuticals compositions comprising the 2S, 4R, ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates, that are substantially free of the 2R, 4S ketoconazole enantiomer are useful to reduce cortisol synthese and for the treatment of type 2 diabetes, hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other diseases and conditions, including but not limited to Cushing's Syndrome, depression, and glaucoma.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: March 20, 2018
    Assignee: CORTENDO AB (PUBL)
    Inventor: Per Marin
  • Patent number: 9725436
    Abstract: Embodiments of the present invention relate to novel cytochrome P450 inhibitors and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the production of cortisol that include metabolic syndrome, obesity, headache, depression, hypertension, diabetes mellitus, Cushing's Syndrome, pseudo-Cushing syndrome, cognitive impairment, dementia, heart failure, renal failure, psoriasis, glaucoma, cardiovascular disease, cancer, stroke or incidentalomas.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: August 8, 2017
    Assignee: CORTENDO AB (PUBL)
    Inventors: Benjamin Eric Blass, Magid A Abou-Gharbia, Wayne E. Childers, Pravin Iyer, Joshodeep Boruwa
  • Publication number: 20150353530
    Abstract: Embodiments of the present invention relate to 4-(phenoxymethyl)-1,3-dioxolane analogs and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the overproduction of cortisol that include metabolic syndrome, and any involving the overproduction of cortisol.
    Type: Application
    Filed: January 31, 2014
    Publication date: December 10, 2015
    Applicant: Cortendo AB (publ)
    Inventors: Benjamin Eric Blass, Magid A. Abou-Gharbia, Wayne E. Childers
  • Patent number: 9198906
    Abstract: Treatment of patients with the 2S,4R ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates is useful for reducing systemic inflammation and cholesterol levels and improving glycemic control.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: December 1, 2015
    Assignee: Cortendo AB (publ)
    Inventor: Timothy Andrew Stewart
  • Patent number: 7960410
    Abstract: The invention concerns the use of ketoconazole and derivatives having a corresponding biological activity, and combinations thereof, in the treatment of abdominal obesity, hypertension, hyperinsulinemia, and elevated blood lipids.
    Type: Grant
    Filed: September 10, 2005
    Date of Patent: June 14, 2011
    Assignee: Cortendo AB
    Inventor: Per Marin
  • Patent number: 7872008
    Abstract: The invention concerns the use of ketoconazole and derivatives having a corresponding biological activity, and combinations thereof, in the treatment of abdominal obesity, hypertension, hyperinsulinemia, and elevated blood lipids.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: January 18, 2011
    Assignee: Cortendo AB
    Inventor: Per Marin
  • Patent number: 7217505
    Abstract: The use of cortisol agonist for preparing a system for diagnosis of the metabolic syndrome and related conditions as belly fatness, insulin resistancy including increased risk of developing senile diabetes, i.e. diabetes type II, high blood fats and high blood pressure, in which system the dose of cortisol agonist is in an interval where a difference is obtained in the inhibitory effect of the autoproduction of cortisol in individuals suffering from the metabolic syndrome, compared to normal values.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: May 15, 2007
    Assignee: Cortendo AB
    Inventor: Per Marin
  • Patent number: 6642236
    Abstract: Ketoconazole and related substances which are inhibitors of cortisol synthesis can be administered to prophylactically treat cardiovascular disease, such as coronary artery disease, artiosclerotic manifestations, and stroke.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: November 4, 2003
    Assignee: Cortendo AB
    Inventor: Per Märin
  • Publication number: 20020055512
    Abstract: The present invention relates to compositions for controlled release of a cortisol antagonist comprising at least one release rate controlling substance together with said cortisol antagonist and methods of preventing or treating metabolic syndrome, diabetes mellitis type II or symptoms or complications thereof in a mammal, which method comprises administering such a composition to said mammal in an amount effective to treat one or more of the clinical manifestations of metabolic syndrome or diabetes mellitis type II as well as complications thereof.
    Type: Application
    Filed: March 16, 2001
    Publication date: May 9, 2002
    Applicant: CORTENDO AB.
    Inventors: Per Marin, Tomas Landh, Ivan Ostholm
  • Patent number: 6274582
    Abstract: Human growth hormone is used in combination with a cortisol synthesis inhibitor, in particular ketoconazole, for prevention or treatment of conditions related to Metabolis Syndrome (Neuroendocrine Syndrome). Administration can be supplemented by a sex hormone selected from testosterone and natural or synthetic estrogen. Also disclosed are corresponding pharmaceutical compositions.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: August 14, 2001
    Assignee: Cortendo AB
    Inventor: Per Mårin
  • Patent number: 6166017
    Abstract: A method for the medical treatment of diabetes mellitus type II and for counteracting the risk factors forming part of the Metabolic syndrome (also known as the "deadly quartet" or "syndrome X" or the Insulin Resistance Syndrome) in a patient having increased cortisol activity, which method of treatment comprises decreasing said increased cortisol activity in said patient by the steps of providing an inhibitor of cortisol synthesis.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: December 26, 2000
    Assignee: Cortendo, AB
    Inventor: Per Marin
  • Patent number: 5849740
    Abstract: The present invention is a method of using ketoconazole or molecules resembling ketoconazole with comparable biological activity for the manufacture of drugs and for medical treatment of diabetes mellitus type II as well as for counteracting the other risk factors associated with the Metabolic Syndrome.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: December 15, 1998
    Assignee: Cortendo AB
    Inventor: Per Marin