Patents Assigned to Cortex Pharmaceuticals, Inc.
  • Patent number: 8642633
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: February 4, 2014
    Assignee: Cortex Pharmaceuticals, Inc.
    Inventors: Leslie Street, Rudolf Mueller, Steven Lee
  • Patent number: 8507482
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, among others.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: August 13, 2013
    Assignee: Cortex Pharmaceuticals, Inc.
    Inventors: Rudolf Mueller, Leslie J. Street
  • Publication number: 20130190351
    Abstract: This invention relates to bicyclic amide compounds, pharmaceutical compositions and methods for use in the prevention and treatment of a variety of conditions and/or disease states including cerebral insufficiency, through the enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors as defined herein. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in other disorders wherein a deficiency in neurotrophic factors is implicated, as well as other disorders as described herein.
    Type: Application
    Filed: July 25, 2012
    Publication date: July 25, 2013
    Applicant: CORTEX PHARMACEUTICALS, INC.
    Inventors: Rudolf Mueller, Leslie Street
  • Publication number: 20130137733
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Application
    Filed: January 31, 2013
    Publication date: May 30, 2013
    Applicant: Cortex Pharmaceuticals, Inc.
    Inventor: Cortex Pharmaceuticals, Inc.
  • Patent number: 8404682
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: March 26, 2013
    Assignee: Cortex Pharmaceuticals, Inc.
    Inventors: Leslie Street, Rudolf Mueller, Steven Lee
  • Patent number: 8263591
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: September 11, 2012
    Assignee: Cortex Pharmaceuticals, Inc.
    Inventors: Rudolf Mueller, Leslie Street
  • Publication number: 20120122861
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, among others.
    Type: Application
    Filed: January 11, 2012
    Publication date: May 17, 2012
    Applicant: CORTEX PHARMACEUTICALS, INC.
    Inventors: Rudolf MUELLER, Leslie J. STREET
  • Patent number: 8168632
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: May 1, 2012
    Assignee: Cortex Pharmaceuticals, Inc.
    Inventors: Rudolf Mueller, Leslie J. Street
  • Patent number: 8119632
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: February 21, 2012
    Assignee: Cortex Pharmaceuticals, Inc.
    Inventors: Rudolf Mueller, Leslie J. Street
  • Patent number: 8013003
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: September 6, 2011
    Assignee: Cortex Pharmaceuticals, Inc.
    Inventors: Leslie Street, Rudolf Mueller, Steven Lee
  • Publication number: 20110003835
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Application
    Filed: September 3, 2010
    Publication date: January 6, 2011
    Applicant: CORTEX PHARMACEUTICALS, INC.
    Inventors: Rudolf Mueller, Leslie Street
  • Publication number: 20100286177
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Application
    Filed: August 8, 2008
    Publication date: November 11, 2010
    Applicant: CORTEX PHARMACEUTICALS, INC.
    Inventors: Rudolf Mueller, Leslie Street
  • Publication number: 20100267728
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Application
    Filed: September 19, 2008
    Publication date: October 21, 2010
    Applicant: CORTEX PHARMACEUTICALS, INC.
    Inventors: Rudolf Mueller, Leslie J. Street, Stanislaw Rachwal, Kashinatham Alisala
  • Patent number: 7799913
    Abstract: This invention related to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed In a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson?s disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions and methods of using these compounds for such treatment.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: September 21, 2010
    Assignee: Cortex Pharmaceuticals, Inc.
    Inventors: Gary A. Rogers, Matthew Allan, Clayton Harris, Jianjie Huang, Christopher M. Marrs, Rudolf Mueller, Stanislaw Rachwal
  • Publication number: 20100173903
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
    Type: Application
    Filed: January 29, 2010
    Publication date: July 8, 2010
    Applicant: CORTEX PHARMACEUTICALS, INC.
    Inventors: Rudolf Mueller, Leslie J. Street
  • Publication number: 20100173902
    Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.
    Type: Application
    Filed: January 29, 2010
    Publication date: July 8, 2010
    Applicant: CORTEX PHARMACEUTICAL, INC.
    Inventors: Rudolf Mueller, Leslie J. Street
  • Publication number: 20100041647
    Abstract: This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
    Type: Application
    Filed: December 28, 2007
    Publication date: February 18, 2010
    Applicant: CORTEX PHARMACEUTICALS, INC.
    Inventors: Rudolf Mueller, Stephen Lee, Sean O'Hare, Gary Rogers, Stan Rachwal, Leslie Street
  • Publication number: 20050228019
    Abstract: The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.
    Type: Application
    Filed: January 26, 2005
    Publication date: October 13, 2005
    Applicants: Cortex Pharmaceuticals, Inc., The Regents of the University of California
    Inventors: Ursula Staubli, Gary Lynch, Sheng Zhong, Laura Colgin
  • Publication number: 20020055508
    Abstract: Compounds of general structural formula (1) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, such as memory impairment, in which AMPA receptors, or synapses utilizing these receptors, are reduced in numbers or efficiency. They may also be used to enhance excitatory synaptic activity in order to restore an imbalance between brain subregions, as in treatment of schizophrenia or schizophreniform behavior.
    Type: Application
    Filed: April 27, 2001
    Publication date: May 9, 2002
    Applicant: Cortex Pharmaceuticals, Inc.
    Inventors: Gary A. Rogers, Christopher M. Marrs
  • Patent number: 6166008
    Abstract: This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. In a particular aspect, the invention relates to methods for the use of AMPA receptor up-modulators in conjunction with antipsychotics for the treatment of schizophrenia. Kits containing the compositions in appropriate form for administration are also provided.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: December 26, 2000
    Assignees: Cortex Pharmaceuticals, Inc., The Regents of the University of California
    Inventors: Steven A. Johnson, Gary S. Lynch, Gary A. Rogers