Patents Assigned to Cortex Pharmaceuticals, Inc.
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Patent number: 8642633Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: GrantFiled: January 31, 2013Date of Patent: February 4, 2014Assignee: Cortex Pharmaceuticals, Inc.Inventors: Leslie Street, Rudolf Mueller, Steven Lee
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Patent number: 8507482Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, among others.Type: GrantFiled: January 11, 2012Date of Patent: August 13, 2013Assignee: Cortex Pharmaceuticals, Inc.Inventors: Rudolf Mueller, Leslie J. Street
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Publication number: 20130190351Abstract: This invention relates to bicyclic amide compounds, pharmaceutical compositions and methods for use in the prevention and treatment of a variety of conditions and/or disease states including cerebral insufficiency, through the enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors as defined herein. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in other disorders wherein a deficiency in neurotrophic factors is implicated, as well as other disorders as described herein.Type: ApplicationFiled: July 25, 2012Publication date: July 25, 2013Applicant: CORTEX PHARMACEUTICALS, INC.Inventors: Rudolf Mueller, Leslie Street
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Publication number: 20130137733Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: ApplicationFiled: January 31, 2013Publication date: May 30, 2013Applicant: Cortex Pharmaceuticals, Inc.Inventor: Cortex Pharmaceuticals, Inc.
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Patent number: 8404682Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: GrantFiled: September 6, 2011Date of Patent: March 26, 2013Assignee: Cortex Pharmaceuticals, Inc.Inventors: Leslie Street, Rudolf Mueller, Steven Lee
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Patent number: 8263591Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: GrantFiled: August 8, 2008Date of Patent: September 11, 2012Assignee: Cortex Pharmaceuticals, Inc.Inventors: Rudolf Mueller, Leslie Street
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Publication number: 20120122861Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, among others.Type: ApplicationFiled: January 11, 2012Publication date: May 17, 2012Applicant: CORTEX PHARMACEUTICALS, INC.Inventors: Rudolf MUELLER, Leslie J. STREET
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Patent number: 8168632Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.Type: GrantFiled: January 29, 2010Date of Patent: May 1, 2012Assignee: Cortex Pharmaceuticals, Inc.Inventors: Rudolf Mueller, Leslie J. Street
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Patent number: 8119632Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: GrantFiled: January 29, 2010Date of Patent: February 21, 2012Assignee: Cortex Pharmaceuticals, Inc.Inventors: Rudolf Mueller, Leslie J. Street
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Patent number: 8013003Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: GrantFiled: May 16, 2008Date of Patent: September 6, 2011Assignee: Cortex Pharmaceuticals, Inc.Inventors: Leslie Street, Rudolf Mueller, Steven Lee
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Publication number: 20110003835Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: ApplicationFiled: September 3, 2010Publication date: January 6, 2011Applicant: CORTEX PHARMACEUTICALS, INC.Inventors: Rudolf Mueller, Leslie Street
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Publication number: 20100286177Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: ApplicationFiled: August 8, 2008Publication date: November 11, 2010Applicant: CORTEX PHARMACEUTICALS, INC.Inventors: Rudolf Mueller, Leslie Street
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Publication number: 20100267728Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: ApplicationFiled: September 19, 2008Publication date: October 21, 2010Applicant: CORTEX PHARMACEUTICALS, INC.Inventors: Rudolf Mueller, Leslie J. Street, Stanislaw Rachwal, Kashinatham Alisala
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Patent number: 7799913Abstract: This invention related to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed In a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson?s disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions and methods of using these compounds for such treatment.Type: GrantFiled: November 25, 2002Date of Patent: September 21, 2010Assignee: Cortex Pharmaceuticals, Inc.Inventors: Gary A. Rogers, Matthew Allan, Clayton Harris, Jianjie Huang, Christopher M. Marrs, Rudolf Mueller, Stanislaw Rachwal
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Publication number: 20100173903Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.Type: ApplicationFiled: January 29, 2010Publication date: July 8, 2010Applicant: CORTEX PHARMACEUTICALS, INC.Inventors: Rudolf Mueller, Leslie J. Street
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Publication number: 20100173902Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors.Type: ApplicationFiled: January 29, 2010Publication date: July 8, 2010Applicant: CORTEX PHARMACEUTICAL, INC.Inventors: Rudolf Mueller, Leslie J. Street
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Publication number: 20100041647Abstract: This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.Type: ApplicationFiled: December 28, 2007Publication date: February 18, 2010Applicant: CORTEX PHARMACEUTICALS, INC.Inventors: Rudolf Mueller, Stephen Lee, Sean O'Hare, Gary Rogers, Stan Rachwal, Leslie Street
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Publication number: 20050228019Abstract: The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.Type: ApplicationFiled: January 26, 2005Publication date: October 13, 2005Applicants: Cortex Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Ursula Staubli, Gary Lynch, Sheng Zhong, Laura Colgin
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Publication number: 20020055508Abstract: Compounds of general structural formula (1) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, such as memory impairment, in which AMPA receptors, or synapses utilizing these receptors, are reduced in numbers or efficiency. They may also be used to enhance excitatory synaptic activity in order to restore an imbalance between brain subregions, as in treatment of schizophrenia or schizophreniform behavior.Type: ApplicationFiled: April 27, 2001Publication date: May 9, 2002Applicant: Cortex Pharmaceuticals, Inc.Inventors: Gary A. Rogers, Christopher M. Marrs
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Patent number: 6166008Abstract: This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. In a particular aspect, the invention relates to methods for the use of AMPA receptor up-modulators in conjunction with antipsychotics for the treatment of schizophrenia. Kits containing the compositions in appropriate form for administration are also provided.Type: GrantFiled: October 26, 1998Date of Patent: December 26, 2000Assignees: Cortex Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Steven A. Johnson, Gary S. Lynch, Gary A. Rogers