Abstract: The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
Type:
Application
Filed:
October 5, 2015
Publication date:
April 7, 2016
Applicant:
Cortexyme, Inc.
Inventors:
Andrei KONRADI, Stephen S. DOMINY, Casey CRAWFORD LYNCH, Craig COBURN, Joseph VACCA
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