Patents Assigned to Corthera, Inc.
  • Method of lowering mortality
    Patent number: 9579363
    Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: February 28, 2017
    Assignee: Corthera Inc.
    Inventors: Elaine Unemori, Sam L Teichman, Gad Cotter, Dennis Stewart, Martha Jo Whitehouse
  • Method of lowering mortality
    Patent number: 9205132
    Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: December 8, 2015
    Assignee: CORTHERA, INC.
    Inventors: Elaine Unemori, Sam L. Teichman, Gad Cotter, Dennis Stewart, Martha Jo Whitehouse
  • Method of treating neurohormonal imbalance
    Patent number: 9066916
    Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: June 30, 2015
    Assignee: CORTHERA, INC.
    Inventors: Elaine Unemori, Sam Teichman, Gad Cotter, Dennis Stewart, Martha Jo Whitehouse
  • Prediction and prevention of preeclampsia
    Patent number: 8574851
    Abstract: The present disclosure relates to methods for detecting an increased risk of preeclampsia, determining the presence of preeclampsia, reducing the likelihood that preeclampsia will develop and treating preeclampsia. It also provides methods of measuring relaxin levels in a biological sample of a pregnant woman.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: November 5, 2013
    Assignees: Corthera, Inc., University of Pittsburgh-Of the Commonwealth System of Higher Education, University of Florida Research Foundation, Inc.
    Inventors: Dennis Stewart, Kirk P. Conrad, Arundhathi Jeyabalan
  • Method of treating dyspnea associated with acute heart failure by administering H2 relaxin
    Patent number: 8415301
    Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: April 9, 2013
    Assignee: Corthera, Inc.
    Inventors: Elaine Unemori, Sam L Teichman, Gad Cotter, Dennis R Stewart, Martha J Whitehouse
  • Method of treating dyspnea associated with acute heart failure
    Patent number: 8372809
    Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: February 12, 2013
    Assignee: Corthera, Inc.
    Inventors: Elaine Unemori, Sam L Teichman, Gad Cotter, Dennis R Stewart, Martha J Whitehouse
  • Method of treating dyspnea associated with acute heart failure
    Patent number: 8053411
    Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: November 8, 2011
    Assignee: Corthera, Inc.
    Inventors: Elaine Unemori, Sam L. Teichman, Gad Cotter, Dennis R. Stewart, Martha Jo Whitehouse
  • Methods and compositions for control of fetal growth via modulation of relaxin
    Patent number: 8026215
    Abstract: The invention relates to the method for treatment, diagnosis and prevention of diseases related to fetal growth and placental insufficiency and comprises methods including inhibiting or increasing relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, and relaxin receptor activity. The invention also relates to screening assays to identify compounds that modulate relaxin and/or relaxin receptor activity. The invention further relates to gene therapy methods utilizing relaxin and relaxin-related sequences for the treatment and prevention of diseases related to fetal growth and placental insufficiency.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: September 27, 2011
    Assignee: Corthera, Inc.
    Inventor: Elaine Unemori
  • Method of Treating Dyspnea Associated with Acute Heart Failure
    Publication number: 20100048475
    Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
    Type: Application
    Filed: May 15, 2009
    Publication date: February 25, 2010
    Applicant: Corthera, Inc.
    Inventors: Elaine Unemori, Sam L. Teichman, Gad Cotter, Dennis R. Stewart, Martha Jo Whitehouse
  • Method of Promoting Wound Healing
    Publication number: 20100041603
    Abstract: The present disclosure relates to methods of administering relaxin to promote wound healing and reduce scar formation. The disclosure further contemplates the use of relaxin in reconstructive and plastic surgery.
    Type: Application
    Filed: May 13, 2009
    Publication date: February 18, 2010
    Applicant: Corthera, Inc.
    Inventor: Dennis R. Stewart
  • METHODS AND COMPOSITIONS FOR CONTROL OF FETAL GROWTH VIA MODULATION OF RELAXIN
    Publication number: 20090318356
    Abstract: The invention relates to the method for treatment, diagnosis and prevention of diseases related to fetal growth and placental insufficiency and comprises methods including inhibiting or increasing relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, and relaxin receptor activity. The invention also relates to screening assays to identify compounds that modulate relaxin and/or relaxin receptor activity. The invention further relates to gene therapy methods utilizing relaxin and relaxin-related sequences for the treatment and prevention of diseases related to fetal growth and placental insufficiency.
    Type: Application
    Filed: May 29, 2009
    Publication date: December 24, 2009
    Applicant: Corthera, Inc.
    Inventor: Elaine UNEMORI
  • Methods and compositions for control of fetal growth via modulation of relaxin
    Patent number: 7553813
    Abstract: The invention relates to the method for treatment, diagnosis and prevention of diseases related to fetal growth and placental insufficiency and comprises methods including inhibiting or increasing relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, and relaxin receptor activity. The invention also relates to screening assays to identify compounds that modulate relaxin and/or relaxin receptor activity. The invention further relates to gene therapy methods utilizing relaxin and relaxin-related sequences for the treatment and prevention of diseases related to fetal growth and placental insufficiency.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: June 30, 2009
    Assignee: Corthera, Inc.
    Inventor: Elaine Unemori