Abstract: Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.
Type:
Grant
Filed:
April 7, 2004
Date of Patent:
January 4, 2011
Assignee:
Cortical PTY LTD
Inventors:
Eric Francis Morand, Magdy Naguib Iskander, Colin Edward Skene
Abstract: Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.
Type:
Application
Filed:
June 30, 2010
Publication date:
December 23, 2010
Applicant:
Cortical Pty LTD
Inventors:
Eric Francis Morand, Magdy Naguib Iskander, Colin Edward Skene
Abstract: Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy. Novel heterocyclic compounds are also provided for.
Type:
Grant
Filed:
June 6, 2003
Date of Patent:
May 4, 2010
Assignee:
Cortical Pty Ltd
Inventors:
Eric Francis Morand, Magdy Naguib Iskander, Basil Danylec