Abstract: The present invention relates to certain cortexolone derivatives of formula (I) and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
Abstract: The present invention relates to certain cortexolone derivatives of formula (I) and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
Abstract: The present invention provides a novel liquid composition in the form of an emulsion or microemulsion for rectal administration comprising at least one dye, at least one emulsifier, and at least one physiologically acceptable excipient, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum. Preferably, said diagnostic endoscopic procedure of sigmoid colon and/or rectum is an anoscopy, a proctoscopy, a rectoscopy and/or a sigmoidoscopy.
Type:
Grant
Filed:
January 29, 2015
Date of Patent:
February 23, 2021
Assignee:
COSMO TECHNOLOGIES LIMITED
Inventors:
Luigi Moro, Enrico Frimonti, Luigi Maria Longo
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Grant
Filed:
August 9, 2019
Date of Patent:
December 1, 2020
Assignee:
COSMO TECHNOLOGIES LIMITED
Inventors:
Luigi Moro, Luigi Maria Longo, Enrico Frimonti, Alessandro Repici
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Type:
Application
Filed:
May 22, 2020
Publication date:
November 12, 2020
Applicant:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto VILLA, Massimo PEDRANI, Mauro AJANI, Lorenzo FOSSATI
Abstract: The present disclosure relates to methods for treating intestinal diseases presenting at least one inflammatory component such as inflammatory bowel disease or diverticular disease and/or maintaining remission of intestinal diseases presenting at least one inflammatory component such as inflammatory bowel disease (IBD) or diverticular disease using budesonide MMX compositions.
Type:
Application
Filed:
August 6, 2019
Publication date:
May 28, 2020
Applicants:
COSMO TECHNOLOGIES LIMITED, SANTARUS, INC.
Inventors:
Gerald Thomas PROEHL, Wendell WIERENGA, Michael Fangching HUANG, Emerson David BALLARD, II, Luigi MORO
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Type:
Grant
Filed:
January 31, 2019
Date of Patent:
May 26, 2020
Assignee:
Cosmo Technologies Limited
Inventors:
Roberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
Abstract: The present invention relates to certain cortexolone derivatives of formula (I) and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Grant
Filed:
April 25, 2018
Date of Patent:
September 17, 2019
Assignee:
COSMO TECHNOLOGIES LIMITED
Inventors:
Luigi Moro, Luigi Maria Longo, Enrico Frimonti, Alessandro Repici
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Type:
Application
Filed:
January 31, 2019
Publication date:
July 4, 2019
Applicant:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto VILLA, Massimo PEDRANI, Mauro AJANI, Lorenzo FOSSATI
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Type:
Grant
Filed:
September 24, 2018
Date of Patent:
June 4, 2019
Assignee:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
Abstract: The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
Type:
Application
Filed:
December 28, 2018
Publication date:
May 9, 2019
Applicant:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto VILLA, Massimo PEDRANI, Mauro AJANI, Lorenzo FOSSATI
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Type:
Application
Filed:
September 24, 2018
Publication date:
February 14, 2019
Applicant:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto VILLA, Massimo PEDRANI, Mauro AJANI, Lorenzo FOSSATI
Abstract: The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
Type:
Application
Filed:
September 24, 2018
Publication date:
January 24, 2019
Applicant:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto VILLA, Massimo PEDRANI, Mauro AJANI, Lorenzo FOSSATI
Abstract: The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Type:
Application
Filed:
September 17, 2018
Publication date:
January 17, 2019
Applicant:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto VILLA, Massimo PEDRANI, Mauro AJANI, Lorenzo FOSSATI
Abstract: The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
Type:
Application
Filed:
September 17, 2018
Publication date:
January 17, 2019
Applicant:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto VILLA, Massimo PEDRANI, Mauro AJANI, Lorenzo FOSSATI
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Type:
Grant
Filed:
September 17, 2018
Date of Patent:
January 8, 2019
Assignee:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Type:
Grant
Filed:
July 13, 2018
Date of Patent:
December 18, 2018
Assignee:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
Abstract: The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
Type:
Grant
Filed:
July 11, 2017
Date of Patent:
December 4, 2018
Assignee:
COSMO TECHNOLOGIES LIMITED
Inventors:
Roberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati