Abstract: The present invention relates to substituted-diazenylanilines of the formula I and their nucleotide conjugates, complexes, salts which may be used potentially as fluorescent quenchers in chemical and biological sciences such as cell imaging applications, diagnostics, fluorescent and non-fluorescent tags, pharmaceuticals and other useful applications, and a process of preparing said new compounds. More particularly, the present invention relates to 2,2?-((4-((2,5-disubstituted-4-((4-nitrophenyl)diazenyl)phenyl)diazenyl)-2/3-substituted-phenyl)azanediyl)dialkanol, processes for preparing said compounds and their use as fluorescent quenchers in cell imaging applications, diagnostics, fluorescent and non-fluorescent tags, pharmaceuticals and other useful applications.

Abstract: The present invention relates to a composition for fuel cell membranes and a process for the preparation thereof. In particular, the present invention relates to thermo-mechanically and chemically stable polymer electrolyte membranes which have been prepared without compromising proton conductivity by using multifunctional polydopamine and mechanically robust nanocellulose.

Abstract: The present invention relates to process for the preparation of cannabidiol (A) from the coupling of (D) and (E) through the intermediates (C) and (D) starting from compound (B). The invention further relates to the novel compounds (B), (C), (D) and (E) and reagents used in this process. More specifically, this invention provides the manufacturing of Cannabidiol (A) in milligram to gram or kilogram scale.

Abstract: The present invention relates to partially bio-based and bio-compatible polyurethane microcapsules. More particularly, the present invention relates to partially bio-based and bio-compatible polyurethane microcapsules for sustained release of an active ingredient. The present invention also relates to a process for the preparation of the partially bio-based and bio-compatible polyurethane microcapsules.

Abstract: The present invention deals with development of a novel process for manufacturing moisture resistant glossy finish hybrid green polymeric composites with variable density in range of 0.2-1.68 g/cc, low water/moisture absorption in the range of 0.1-1.3%, tensile strength and tensile modulus in range of 6.5-105 MPa and 250-6850 MPa, respectively and to the best of our knowledge the fabricated hybrid green composites has not yet developed universally using different types of industrial wastes particulates. Moreover, hybrid composites developed using industrial wastes, natural fibres and epoxy/polyester/polyurethane polymers is a unique materials and have multifunctional applications in wider spectrum as an alternative to wood, synthetic wood, wood plastic composites, screen printing sheet, plastic, fibre and glass reinforced polymer products, including tin sheet.

Abstract: Anion-exchange membranes are useful for electro-membrane processes such as electrodialysis (water desalination, separation of inorganics from organic molecules, separation of specific inorganic ion, etc.), in-situ ion-exchange and ion substitution, electro-deionization for producing ultrapure water, polymer electrolyte membrane for alkaline fuel cell and electrolysis applications. The present invention discloses an acid and base resistant fluorinated hydrocarbon based anion-exchange membrane and its method of preparation thereof. In the first step co-polymerization is carried out between N-isopropylacrylamide and 1-vinylimidazole. In the second step, obtained inter-polymer of isopropylacrylamide-co-vinylimidazole co-polymer is mixed with poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-co-HFP) (IA-co-VI/PVDF-co-HFP), which is used for casting membrane film of desired thickness. The obtained casted membrane thin film is quaternized in methyl iodide solution.

Abstract: The present invention discloses modified forms of plasmin with advantageous properties. As compared to their natural unmodified form, these variants exhibit significantly modulated kinetics in terms of delayed inhibition characteristics in the presence of specific inhibitors, such as ?2-antiplasmin (?2-AP). These include PEG-conjugated thiol derivatives of truncated plasmin with potential clinical applications in various regimens of thrombolytic therapies.

Abstract: The present disclosure relates to a new, simple, two step synthesis of Indolmycin and its derivatives of formula (I), in 4-5 hours. Formula (I) wherein said process comprising the step of: 10 (a) reacting indole derivative with methyl magnesium bromide in a suitable solvent at a temperature in the range of 0-30° C. followed by adding ethyl epoxy butanone in a suitable solvent at ?20° C. for a period of 1-2 hrs and maintaining the obtained reaction mixture for 1 hr at ?20° C. to obtain a compound; and (b) passing the compound obtained at step a), base and N-methylated quinidine 15 through solid-solid continuous flow reactor for 1 minute to obtain the compound of formula (I).

Abstract: The present invention relates to a crystalline, two dimensional polymer of Formula I and a process for the preparation thereof.

Abstract: The present invention relates to the novel formulation for sustained or delayed release of rohitukine-rich Dysoxylum binectariferum extract/fraction and a process for preparing the same wherein the extract is wet-granulated using excipients i.e. biodegradable polymers and/or non-biodegradable polymers alone or in combination, and the said granules are either filled into a capsule or compressed into a tablet. The said formulation comprising a granulated extract/fraction of rohitukine-rich Dysoxylum binectariferum with polymers has resulted in a sustained release of the extract or fraction over a period of 16-24 hrs. The said formulations are useful in the treatment of inflammatory diseases.

Abstract: The present invention provides highly efficient process for the preparation of enantiomerically enriched Sitagliptin of Formula (Ia). More particularly, a direct rhodium catalyzed asymmetric hydrogenation in the presence of bis-phosphine chiral ligand has been developed to yield enantiopure Sitagliptin product with the highest enantiomeric excess of 85-99.9%.

Abstract: The current invention relates to a method for producing an alcohol-free, antimicrobial, moisturising hand sanitizer comprising (i) a polymer-based nanoemulsion including one or more active compounds selected from cyanovirin-N (CV-N), cannabidiol (CBD) and palmitic acid (PA); and (ii) an aqueous gel-like moisturizing composition comprising xanthan gum, glycerol and a preservative such as citric acid. The invention further relates to an alcohol-free, antimicrobial, moisturising hand sanitizer produced by the method of the invention, as well as to use of the hand sanitizer as an antimicrobial, in particular an antiviral agent.

Abstract: The present invention discloses a film comprising porous, amorphous polybenzimidazole (PBI) and at least one filler for use as a separator in a lithium ion battery and a process for preparation thereof.

Abstract: The present invention relates to a process for the preparation of tapentadol and analogs or compounds or stereoisomers of formula (I), Formula I wherein, A is aryl, heteroaryl, and cycloalkyl; R is H, OH, OR1, halogen, C1-C12 alkyl, cycloalkyl, aryl or heteroaryl; R1 is C1-C12 alkyl, cycloalkyl, aryl or heteroaryl, wherein each of these groups may further be substituted with one or more substituent selected from H, OH, halogen, CN, NO2, C1-C4 alkyl or phenyl. Further, the multi-step process involves no column chromatography purification until the very last step. This makes this process highly commercially viable and industrially useful.

Abstract: The invention described herein relates to the compounds of Formula I for treating diseases and disorders for which inhibition or modulation of the topoisomerase I enzyme produces a physiologically beneficial response, in particular for the treatment of breast cancer. Also provided is the process of preparing compounds of Formula I.

Abstract: The present invention provides a non-hazardous, improved continuous oxidation process for the preparation of substituted benzoic acid of formula (I) by using continuous process reactor system with improved process controls.

Abstract: The present invention relates to the process for the preparation of Nitazoxanide and intermediates thereof. The invention explores readily available starting materials with reaction conditions that are suitable for industrial scale applications. The present invention discloses, a single vessel process to prepare 5-nitrothiazol-2-amine starting from a very basic starting material 1,1-dimethoxy-N, N-dimethylmethanamine. Overall intermediates throughout the process is free from column chromatography and the final product Nitazoxanide is purified by precipitation. All the synthesized compounds were confirmed by various spectroscopic techniques such as Fourier transform infrared spectroscopy, 1H NMR, 13C NMR, HRMS and elemental analysis.

Abstract: The present invention conveys a fractionation method to isolate different bioactive Phytocannabinoids by solid phase extraction using HP-20 resins and one step method to synthesize C— and O-?-D-glycoside derivatives of Cannabinoid by using a ?-D-glucose donor (O-Glycosyl trichloroacetimidate donor) to obtain glycosidic derivatives. The novel C-glycosides of Cannabinoids displayed significant anti-proliferative properties against wide range of human cancer cell lines as compared to their respective parent molecules. Furthermore, the C— and O glycosides of Cannabinoids also showed anti-invasive and anti-migratory activities against metastatic cancer cells of breast and pancreatic origin. When applied in combination with DNA damaging agent (5-Fluorouracil) to colorectal cancer cells, the C— and O-glycosides of Cannabinoids potentiate DNA damaging property and thus augment apoptosis resulting in an increment in the efficacy of DNA damaging drugs.

Abstract: A Bidirectional, Linear and Binary, Segmented Antagonistic Servomechanism-based Shape Memory Alloy (SMA) Actuator comprising a main stroke transmitting lever (11 or 18) and a plurality of part-modules (15A or 15B) disposed in a closely spaced arrangement and adapted to undergo a reciprocal translation in a first direction. wherein, the part-modules comprising a plurality of segments having SMA elements (12). The invention provides two configurations arranged in ‘straight’ and ‘cross’ configurations of the SMA elements in the part-modules. Further above configuration are arranged in a tight close space however, the “cross” configuration provides additional 40% compactness. The configurations comprise a “S-type long tail” or “flipped F-type long tail” main stroke transmitting lever and plurality of “straight” or “cross” configurations part modules, respectively.

Abstract: The present invention relates to an antimalarial heterocyclic compound of formula I, dimers thereof and process for the preparation thereof. Further, the present invention relates to a pharmaceutical composition of heterocyclic compound of formula I, dimers thereof for treating malarial infection.