Patents Assigned to Council of Science and Industrial Research
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Publication number: 20130317011Abstract: The present invention provides a compound of general formula A, useful as potential anticancer agents against eleven human cancer cell lines. The present invention further provides a process for the preparation of diaryl ether linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates attached through different alkane spacers of general formula A.Type: ApplicationFiled: March 30, 2011Publication date: November 28, 2013Applicant: COUNCIL OF SCIENCE AND INDUSTRIAL RESEARCHInventors: Ahmed Kamal, Arutla Viswanath, Jayanti Naga Srirama Chandra Murty, Earla Vijaya Bharathi, Gadupudi Ramakrishna, Farheen Sulthana
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Publication number: 20120219649Abstract: The present invention relates to novel use of the extracts of Cassia tora plant species. The present invention particularly relates to novel use of the extracts of Cassia tora leaves, which show antianxiety activity. The present invention also relates to a process for the preparation of novel herbal extract of Cassia tora species with antianxiety activity and also to the use thereof for the treatment of anxiety.Type: ApplicationFiled: March 26, 2010Publication date: August 30, 2012Applicant: COUNCIL OF SCIENCE AND INDUSTRIAL RESEARCHInventors: Meena Rajnikant Rathod, Bhupendra Dhanvantrai Shethia, Jayant Batukrai Pandya, Prakash Jagjivanbhai Dodiya, Gautam Palit, Manavi Chatterjee, Shibani Sen Gupta, Ashok Kumar Agarwal, Vinay Kumar Khanna
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Patent number: 8114895Abstract: The present invention relates to an isolated bioactive molecule Caerulomycin A, derivatives and analogs thereof as effective immunosuppressive agents. The immunosuppressive property of the compound is targeted in particular against the lymphocytes, CD4+ T cells, CD8+ T cells and B cells and in the production of IL-4 and IFN-? and antibodies. The compound operates through a mechanism by downregulating the expression of activation marker CD28 and upregulating the immunosuppressive marker CTLA-4. Caerulomycin A has previously been isolated from Streptomyces caeruleus and found to have useful antifungal activity. Prior to the present invention however, this compound had not been determined to have immunomodulatory activity.Type: GrantFiled: September 12, 2006Date of Patent: February 14, 2012Assignee: Council of Science and Industrial ResearchInventors: Arvind Kumar Singla, Javed Naim Agrewala, Rakesh Mulraj Vohra, Ravinder Singh Jolly
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Publication number: 20110144171Abstract: The present invention discloses novel compounds of the Formula (1), containing thiophene moieties and pharmaceutically acceptable salts thereof, methods for preparing these compounds, the use of these compounds in prevention and treatment of fungal infections, and pharmaceutical preparations containing these novel compounds.Type: ApplicationFiled: October 1, 2009Publication date: June 16, 2011Applicants: COUNCIL OF SCIENCE & INDUSTRIAL RESEARCH, FDC LIMITEDInventors: Hanumant Bapurao Borate, Sangmeshwer Prabhakar Sawargave, Suleman Ruyajsaheb Maujan, Mohan Anand Chandavarkar, Sharangi Ravinda Vaiude, Vinay Anant Joshi
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Patent number: 7638309Abstract: The present invention relates to detection of pathogenic mycobacteria in clinical specimens such as sputum, cerebrospinal fluid, gastric lavage and tissue biopsies etc., wherein the novel stretch of DNA that lies in the intergenic region between methyl mycolic acid synthase genes mmaA1 and mmaA2 and the flanking region in mmaA1 and mmaA2 genes and is the invention uses a pair of designed oligonucleotide primers that specifically amplifies the target DNA from the clinical specimens.Type: GrantFiled: December 3, 2003Date of Patent: December 29, 2009Assignee: Council of Science and Industrial ResearchInventors: Rakha Hari Das, Ajay Kumar, Meghpati Singh
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Publication number: 20040204617Abstract: The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190±10 &mgr;g per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds/agents including vitamin C have been found to prevent the cs-oxidant induced protein oxidation in vitro.Type: ApplicationFiled: January 8, 2004Publication date: October 14, 2004Applicant: Council of Science and Industrial ResearchInventor: Indu Bhusan Chatterjee
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Publication number: 20040192577Abstract: The present invention describes the process for the preparation of novel sesquiterpene oxide 3S,3aR,7aR,-6 isopropyl-1,1,3,3a-tetramethyl 1,3,3a,4,7,7a-hexahydro-isobenzofuran, of formula (I) by the reaction of elemol with per acid at a temperature range of 20 to 30° C. The invention also deals with the use of compound of formula (1) as a perfuming and flavouring agent.Type: ApplicationFiled: March 26, 2003Publication date: September 30, 2004Applicant: Council of Science and Industrial ResearchInventors: Solimabi Wahidullah, Mangala Babu Govenkar, Shashikumar Keshav Paknikar
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Publication number: 20040191395Abstract: The present invention relates to a flavored nut formulation comprising deep fat fried/dry roasted cashew kernels/peanuts/almonds in the range of 90-98%, salt 1.5-3.0%, oleoresin 1.0-3.0% diluted with 8-12 folds of absolute ethyl alcohol and a process of preparing said flavored nut formulation.Type: ApplicationFiled: March 31, 2003Publication date: September 30, 2004Applicant: Council of Science and Industrial ResearchInventors: Rangasamy Baby Latha, Kodangala Koshawa Bhat, Chitradurga Venkataram Raghavan
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Patent number: 6617319Abstract: The invention provides a process for the isolation of 2-deoxy ecdysterone from Zoanthus sp process comprising the steps (a) preparing crude methanol extract of Zoanthus sp., (b) subjecting the crude methanol extract to fractionation using petroleum ether, ethyl acetate, chloroform, n-butanol and mixtures thereof to yield a fraction, (c) subjecting the active fraction to flash chromatography over silica gel to obtain partially purified active compound, and (d) subjecting the active subfraction obtained from step (c) above to gel permeation chromatography to obtain the active pure compound.Type: GrantFiled: January 16, 2002Date of Patent: September 9, 2003Assignee: Council of Science and Industrial ResearchInventors: Cynthia Olimpia Lydia Gonsalves, Perunninakulath Parameswaran Subrayan, Chandrakant Govind Naik, Chittur Thelakkat Achuthankutty
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Patent number: 6593127Abstract: The present invention relates to a composition useful for early and profuse sporulation in fungi with about 100 fold increase in spore count within 48 hours of inoculation, said composition comprising molasses ranging between 5-20 g/L, Corn Steep Liquor (CSL) ranging between 10-25 g/L, Sodium chloride (NaCl) ranging between 5-15 g/L, calcium sulphate (CaSO4) ranging between 0.1-0.5 g/L, Potassium dihydrogen phosphate (KH2PO4) ranging between 0.001-0.01 g/L, Magnesium sulphate (MgSO4.7 H2O) ranging between 0.001-0.01 g/L, Copper sulphate (CuSO4) ranging between 0.001-0.0050 g/L, Ferrous sulphate (FeSO4) ranging between 0.0009-0.005 g/L, an anti-foam agent, and optionally solidifying agent and a method thereof.Type: GrantFiled: February 4, 2002Date of Patent: July 15, 2003Assignee: Council of Science and Industrial ResearchInventors: Rajinder Kumar Khajuria, Ram Vilas Parsad Sinha, Vijeshwar Verma, Ghulam Nabi Qazi, Sukhdev Swami Handa
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Publication number: 20030111087Abstract: The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190±10 &mgr;g per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds/agents including vitamin C have been found to prevent the cs-oxidant induced protein oxidation in vitro.Type: ApplicationFiled: February 13, 2002Publication date: June 19, 2003Applicant: Council of Science and Industrial ResearchInventor: Indu Bhusan Chatterjee
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Publication number: 20030106562Abstract: This invention relates to a filter for tobacco smoke inhaling/generating/producing device, comprising stipulated amounts of specific grain sizes or combination of grain sizes of activated charcoal for effectively reducing from the mainstream smoke the level of p-benzosemiquinone (p-BSQ), a relatively stable highly reactive major harmful oxidant, without significantly affecting the flavor and taste of the smoke while providing comfortable mouthful of smoke and nicotine delivery, so that the said charcoal filter cigarettes becomes potentially less hazardous safer cigarettes and may be acceptable to the smokers with marked reduction in health risk; the said charcoal filters also effectively reduce the level of nitric oxide and tar from the mainstream smoke.Type: ApplicationFiled: February 13, 2002Publication date: June 12, 2003Applicant: Council of Science and Industrial ResearchInventor: Indu Bhusan Chatterjee
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Patent number: 6191279Abstract: The invention relates to novel dipyrano-quinolinone class of compounds having the general formula: Wherein R is hydrogen, alkyl optionally substituted about C-1 to C-10 alkenyl optionally substituted about C-1 to C-10 with one or more double bounds, alkynyl optionally substituted about C-1 to C-10 with one or more triple bonds, aryl, hetero aryl, carbocyclic aryl, alkyl aryl, alcyclic compounds, C-1 to C-6 alkyl with terminal dialkyl amino group, thio alkyl, hydroxyl alkyl groups; R1 is H, lower dialkyl amino alkyls such as methyl, ethyl, propyl, and other alkyl groups or b-amino acid moieties, hydroxy alkyl groups having optionally substituted about C-1 to C-10 carbons, acid amides such as aliphatic acids, aromatic acids, sulphonic acids trihalo acids.Type: GrantFiled: May 28, 1999Date of Patent: February 20, 2001Assignee: Council of Science & Industrial ResearchInventors: Mukund Keshao Gurjar, Gangavaram Vasantha Madhava Sharma, Aindivelu Ilangovan, Ven Narayanan