Abstract: The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
Type:
Grant
Filed:
July 23, 2007
Date of Patent:
March 27, 2012
Assignee:
Council of Scientific & Industrial Research of Rafi Marg
Abstract: The present invention relates to an improved process of analytical and quantitative isolation of withaferin-A from Withania somnifera (Sanskrit: Ashwagandha, English: winter cherry) and other plants and products therefrom, said method comprising steps of selecting most appropriate extraction medium composition, with extraction solvent system consisting of a defined admixture of water and alcohol in a range of proportion of alcohol within a narrow range of (methanol, ethanol etc.
Type:
Application
Filed:
March 30, 2004
Publication date:
December 1, 2005
Applicant:
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH RAFI MARG
Abstract: A process is disclosed for the preparation of biodiesel, whereby oil is subjected to catalytical transesterification, settling, separation, bubble washing and micro filtration at controlled conditions of temperature and turbulence. The process enables production of high quality fuel, termed as biodisel, within a period of as low as 50 hrs. The fuel can be used without blending with any conventional fuel.
Type:
Application
Filed:
November 24, 2003
Publication date:
May 26, 2005
Applicant:
Council of Scientific and Industrial Research of Rafi Marg
Abstract: The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.
Type:
Application
Filed:
April 13, 2004
Publication date:
May 12, 2005
Applicant:
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH RAFI MARG
Abstract: The present invention describes a novel and very quick bacterial system based screening protocol to detect UV protectant molecules and determining their efficacy for the extent of protection against Ultraviolet radiation in biological systems, identifying a new use of the compound menthyl benzoate as efficient UV protectant suitable for providing protection against the harmful effects of ultraviolet radiation and the extent of protection provided by menthyl benzoate.
Type:
Grant
Filed:
June 17, 2003
Date of Patent:
December 14, 2004
Assignee:
Council of Scientific & Industrial Research Rafi
Marg
Abstract: The present invention relates to an adipocyte Insulin adplnsl with Insulin A and B chains of SEQ ID Nos. 1 and 2, a effective method of treating type 2 diabetes in a subject using adipocyte insulin, said method comprising steps of administering the insulin to a diabetic intraperitoneally, an Insulin gene of SEQ ID No. 3, a process of isolating protein Insulin from the adipocytes of the Carp, said method comprising steps of reverse transcripting RNA of adipocytes to obtain cDNA, using oligonucleotide primers of SEQ ID Nos. 5 and 5 to identify AdpInsl gene from cDNA, and deducing amino acid sequence from cDNA to obtain protein Insulin, and an adipocyte of Catla Catla useful for producing the said Insulin.
Type:
Application
Filed:
March 26, 2003
Publication date:
March 18, 2004
Applicant:
Council of Scientific and Industrial Research Rafi Marg
Abstract: The present invention provides a pharmaceutical composition comprising an effective amount of an extract or lyophilized extract or at least one bioactive fraction obtained from plant woodfordia ftuticosa along with one or more pharmaceutically acceptable additives/carriers for treating ulcer caused by the conditions such as stress induced ulcer, peptic ulcer, cold restraint induced ulcer, drug induced ulcer and acid induced ulcer, also used as specific inhibitor of gastric H+,K+-ATPase and anti-Helicobacter pylori activity.
Type:
Application
Filed:
March 27, 2003
Publication date:
February 5, 2004
Applicant:
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, RAFI MARG
Inventors:
Pratap K. Das, Niranjan P. Sahu, Sukdeb Banerjee, Suchandra Sett, Suchandra Goswami, Samir Bhattacharya
Abstract: The present invention describes a novel and very quick bacterial system based screening protocol to detect UV protectant molecules and determining their efficacy for the extent of protection against Ultraviolet radiation in biological systems, identifying a new use of the compound menthyl benzoate as efficient UV protectant suitable for providing protection against the harmful effects of ultraviolet radiation and the extent of protection provided by menthyl benzoate.
Type:
Application
Filed:
June 17, 2003
Publication date:
November 20, 2003
Applicant:
Council of Scientific and Industrial Research Rafi Marg
Abstract: Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
Type:
Application
Filed:
August 27, 2001
Publication date:
March 27, 2003
Applicant:
Council of Scientific and Industrial Research of Rafi Marg, a New Delhi, India corporation
Abstract: This invention particularly relates to a thick film resistor and a process for the preparation of said thick firm resistor useful for making strain gauge with enhanced gauge factor upto 1000. The thick film resistor of the present invention is obtained by inducing the strain sensitivity in thick film resistor after its fabrication on substrate by coating it with a formulation capable of gauge factor enhancement and subjecting it to high temperature in furnace. The usage of thick film resistor have industrial applications such as hybrid circuit and thermistors etc.
Type:
Grant
Filed:
April 26, 1999
Date of Patent:
October 30, 2001
Assignee:
Council of Scientific & Industrial Research of Rafi
Marg
Abstract: The laevo and dextro forms of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and similar derivatives thereof have substantially double the post-coital anti-fertility activity of the known racemic compound. The resolution of such known compound into the l- and d-isomeric forms may be carried out using di-p-toluoyl-l-tartaric acid monohydrate or di-p-toluoyl-d-tartaric acid.
Type:
Grant
Filed:
September 22, 1981
Date of Patent:
May 8, 1984
Assignee:
Council of Scientific and Industrial Research Rafi Marg
Inventors:
Mohammad Salman, Suprabhat Ray, Ved P. Kamboj, Nitya Anand