Patents Assigned to Covance Inc.
  • Patent number: 7682572
    Abstract: A tissue microarray includes frozen tissue cores that extend from the top of the tissue microarray to a release. The release is a material from which embedding material of the tissue microarray can easily be removed. A stiffener is used with the release to maintain a flat shape of the release. The tissue cores may be formed from whole (i.e., paraffin-free) frozen tissue. A method and tool for manufacturing the tissue microarray are also disclosed.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: March 23, 2010
    Assignee: Covance, Inc.
    Inventors: Andrew Postoyalko, John Roberts
  • Publication number: 20080172182
    Abstract: Clinical data that are measured at a plurality of sequential time points are interpreted by monitoring the Z-value of the clinical data. The Z-value of the measured data is calculated at each of the time points. The calculated Z-values are plotted and compared against a pre-selected Z-value, which may be Z=5, in one exemplary embodiment. The clinical data are determined to have undergone a statistically significant change, compared to a baseline value BV of the data, when the calculated Z-value for the measured data is greater than or substantially equal to the pre-selected Z-value. In this way, signal detection from biomarker data may be enhanced. Also, the toxicity level of drugs that are tested in clinical trials may be determined in a more reliable fashion.
    Type: Application
    Filed: January 12, 2007
    Publication date: July 17, 2008
    Applicant: Covance, Inc.
    Inventor: Gordon F. Kapke
  • Patent number: 6934578
    Abstract: A system displays time-series data, such as electrocardiographic data. The data may be displayed as a trace with markers identifying data features. The markers may be automatically sequenced by the system.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: August 23, 2005
    Assignee: Covance Inc.
    Inventor: Douglas J. Ramseth