Abstract: An ampoule filling and sealing machine with feeding, filling, sealing and loading stations. A horizontally oriented endless chain drive moves the ampoules through the filling and sealing stations. Belts or a reciprocating agitator are provided in the feeding station. A plurality of spring-loaded movable rails and a final stationary rail guide the line of ampoules in the filling station. The filled ampoules in the sealing station are spun by rotating pinions of cylindrical rollers on the endless chain drive in cooperation with inclined discs. In the loading station a channel receives a line of sealed ampoules. One side of the middle portion of the channel is a horizontal flat spring backed up by a spring-loaded bar. A fixed stop is spaced from the backing bar. A spring-loaded gate is at the inlet to each loading tray.