Patents Assigned to CRC Compagnia di Recerca Chimica S.A.
  • Novel method for preparing N(1)-alkylated-5-phenyl-7-substituted-2-deoxy-1,4-benzodiazepines
    Patent number: 4226766
    Abstract: A method for preparing N(1)-alkylated-5-phenyl-7-substituted deoxy-1,4-benzodiazepines utilizing a polyphosphoric acid alkyl ester of the formula: ##STR1## wherein R.sub.3 is an alkyl radical with up to 4 carbon atoms as the alkylating agent, is described.
    Type: Grant
    Filed: July 27, 1978
    Date of Patent: October 7, 1980
    Assignee: CRC Compagnia di Recerca Chimica S.A.
    Inventors: Franjo Kajfez, Vitomir Sunjic, Vesna Caplar
  • Optically active 1,4-benzodiazepines and process for the preparation thereof
    Patent number: 3998811
    Abstract: Optically active compounds having the formula ##STR1## having an asymmetric carbon atom in position 3 having the S configuration and wherein R.sub.1 is selected from the class consisting of hydrogen, halogen, nitro, and trifluoromethyl groups, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl groups and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxy phenyl, benzyl, hydroxy benzyl, and 3'-methyleneindolyl groups.They are obtained by reaction of a compound having the formula ##STR2## with a compound of the formula wherein A is a protective group.The compounds of formula I have sedative and tranquilizing properties.
    Type: Grant
    Filed: July 30, 1974
    Date of Patent: December 21, 1976
    Assignee: CRC Compagnia di Recerca Chimica S.A.
    Inventors: Franjo Kajfez, Nikola Blazevic, Vitomir Sunjic