Patents Assigned to Creabilis Therapeutics S.R.L.
  • Polymer conjugates of Box-A of HMGB1 and Box-A variants of HMGB1
    Patent number: 9707298
    Abstract: The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: July 18, 2017
    Assignee: CREABILIS THERAPEUTICS S.R.L.
    Inventors: Silvio Traversa, Chiara Lorenzetto, Valentina Mainero, Sebastiano Morena, Silvano Fumero, Luca Beccaria
  • Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excesssive cell proliferation
    Publication number: 20060210553
    Abstract: The present invention relates to the use of the alkaloid K252 and its analogues or derivatives to prepare topical drugs for the treatment of disorders characterised by hyperproliferation of keratinocytes.
    Type: Application
    Filed: July 23, 2003
    Publication date: September 21, 2006
    Applicant: Creabilis Therapeutics S.R.L.
    Inventor: Carlo Pincelli