Patents Assigned to Creare Inc.
  • Patent number: 8656908
    Abstract: Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: February 25, 2014
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention, Creare Inc.
    Inventors: Mark J. Papania, James J. Barry, Mark C. Bagley, Nabil A. Elkouh, Darin Knaus, Robert Trabka
  • Patent number: 8021737
    Abstract: A protective cover system for inhibiting corrosion of a metallic object. The protective cover system includes a cover for defining a microenvironment adjacent a metallic object and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: September 20, 2011
    Assignee: Creare Inc.
    Inventors: Nabil A. Elkouh, Jeffrey J. Breedlove, Bruce R. Pilvelait
  • Patent number: 7954486
    Abstract: Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: June 7, 2011
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention, Creare Inc.
    Inventors: Mark J. Papania, James J. Barry, Mark C. Bagley, Nabil A. Elkouh, Darin Knaus, Robert Trabka
  • Publication number: 20110027523
    Abstract: A protective cover system for inhibiting corrosion of a metallic object. The protective cover system includes a cover for defining a microenvironment adjacent a metallic object and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment.
    Type: Application
    Filed: October 1, 2010
    Publication date: February 3, 2011
    Applicant: CREARE INC.
    Inventors: Nabil A. Elkouh, Jeffrey J. Breedlove, Bruce R. Pilvelait
  • Publication number: 20100255247
    Abstract: A protective cover system for inhibiting corrosion of a metallic object. The protective cover system includes a cover for defining a microenvironment adjacent a metallic object and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment.
    Type: Application
    Filed: June 16, 2010
    Publication date: October 7, 2010
    Applicant: CREARE INC.
    Inventors: Nabil A. Elkouh, Jeffrey J. Breedlove, Bruce R. Pilvelait
  • Patent number: 7759265
    Abstract: A protective cover system for inhibiting corrosion of a metallic object. The protective cover system includes a cover for defining a microenvironment adjacent a metallic object and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: July 20, 2010
    Assignee: Creare Inc.
    Inventors: Nabil A. Elkouh, Jeffrey J. Breedlove, Bruce R. Pilvelait
  • Publication number: 20100132930
    Abstract: A flexible heat/mass exchanger constructed of flexible layers defining a flow channel and exterior surfaces. The heat/mass exchanger utilizes a working liquid, such as water, that is present in the flow channel during use. The heat/mass exchanger uses one or more porous and/or permeable materials to allow mass exchange between the working liquid in the flow channel and the environment surrounding the heat/mass exchanger. In a cooling mode, evaporation of the working liquid occurs via the mass exchange. In a dehumidification mode, moisture in the surrounding environment is transported to the working liquid via the mass exchange. In some embodiments, the heat/mass exchanger is made of a number of flexible sheets of material. One or more flexible heat/mass exchangers may be used to form a semi-closed system, such as a personal cooling system with a circulating coolant loop, or an open system, such as a personal hydration system.
    Type: Application
    Filed: May 2, 2008
    Publication date: June 3, 2010
    Applicant: CREARE, INC.
    Inventors: Michael G. Izenson, Weibo Chen
  • Patent number: 7699804
    Abstract: A fluid ejection system (20) comprising a cartridge (24), an ejector (32, 300) and, optionally, a fill station (28) for filling the cartridge with a fluid, such as a vaccine. In some embodiments (52), the cartridge includes a transfer passageway (96) for receiving fluid from the fill station. In other embodiments (200, 400), the cartridge includes a vented fluid reservoir (208, 408) offset from an ejection chamber (224, 420). In yet other embodiments (500, 600), the cartridge includes a vented fluid reservoir chamber (512, 636) inline with the ejection chamber (508, 644). In still other embodiments (700, 1000, 1100), the cartridge includes first and second chambers (728, 736, 1036, 1048, 1136, 1148) initially fluidly sealed from on another by a valve, e.g., either a traveling valve (704, 800, 900, 1200, 1300) or a temporarily stationary valve (1004, 1104).
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: April 20, 2010
    Assignee: Creare Inc.
    Inventors: James J. Barry, Mark C. Bagley, Peter L. Burghardt, Steven J. Fulton
  • Patent number: 7561051
    Abstract: An apparatus for locating a magnet and/or determining the orientation of the apparatus relative to the magnet. In one embodiment, the apparatus includes a multi-axis magnetic field sensor movable in a reciprocating manner so as to permit sensor readings at multiple spaced locations. In another embodiment, the apparatus includes a plurality of multi-axis magnetic field sensors arrayed along a straight line. The apparatus may be used in a number of medical and other applications, including tissue resection, tracking movement of a medical device in a body cavity and tracking movement of an internal organ.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: July 14, 2009
    Assignee: Creare Inc.
    Inventors: David B. Kynor, Marc A. Kenton
  • Patent number: 7373943
    Abstract: An electro mechanically-assisted control system for use in a second-stage regulator. Regulator control assembly (20?), also referred to as all-electronic (AE) assembly (20?), includes an electromechanical actuator (EMA) sub-assembly (22) for controlling airflow through single air supply line (23). EMA sub-assembly (22) includes electronically controllable actuator (ECA) (34), which removably seals EMA orifice (36) in wall (30) of pilot chamber (32). ECA (34) is electrically connected with and controlled by control electronics (38). The control electronics include programmable microprocessor (40), which is electrically connected with charge and discharge electronics (42), both of which are electrically connected with power supply (44). All-electronic (AE) assembly (20?) has only an EMA sub-assembly and no mechanical actuator sub-assembly.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: May 20, 2008
    Assignee: Creare Inc.
    Inventors: Michael G. Izenson, Patrick J. Magari
  • Publication number: 20070228599
    Abstract: A protective cover system for inhibiting corrosion of a metallic object. The protective cover system includes a cover for defining a microenvironment adjacent a metallic object and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment.
    Type: Application
    Filed: January 31, 2007
    Publication date: October 4, 2007
    Applicant: Creare Inc.
    Inventors: Nabil Elkouh, Jeffrey Breedlove, Bruce Pilvelait
  • Publication number: 20070107782
    Abstract: An electromechanically-assisted control system for use in a second-stage regulator. Regulator control assembly (20?), also referred to as all-electronic (AE) assembly (20?), includes an electromechanical actuator (EMA) sub-assembly (22) for controlling airflow through single air supply line (23). EMA sub-assembly (22) includes electronically controllable actuator (ECA) (34), which removably seals EMA orifice (36) in wall (30) of pilot chamber (32). ECA (34) is electrically connected with and controlled by control electronics (38). The control electronics include programmable microprocessor (40), which is electrically connected with charge and discharge electronics (42), both of which are electrically connected with power supply (44). All-electronic (AE) assembly (20?) has only an EMA sub-assembly and no mechanical actuator sub-assembly.
    Type: Application
    Filed: August 28, 2006
    Publication date: May 17, 2007
    Applicant: Creare Inc.
    Inventors: Michael Izenson, Patrick Magari
  • Patent number: 7189468
    Abstract: A lightweight direct methanol fuel cell unit (20) comprising a fuel cell stack (24) enclosed within a housing (22). In one embodiment the fuel cell stack includes a plurality of polymer electrolyte membrane electrode assemblies (52) stacked alternatingly with a plurality of bipolar plates (48). Each bipolar plate includes a cathode flow field (78) defined by a porous cathode flow field structure (56) and an anode flow field (62) defined by an upper plate (58) and a lower plate (60) separated from one another by a plurality of spacers (64). The anode flow fields are manifolded with one another via manifold embossments (118, 120) that are hermetically sealed with one another with a gasket (126). The fuel cell stack and housing are shaped so as to form four manifold regions (36) in the spaces between the fuel cell stack and housing.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: March 13, 2007
    Assignee: Creare Inc.
    Inventors: Michael G. Izenson, Christopher J. Crowley, Wayde H. Affleck
  • Patent number: 7183230
    Abstract: A protective cover system (100) for inhibiting corrosion of a metallic object. The protective cover system includes a cover (101, 200, 600) for defining a microenvironment and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment. In one embodiment, cover 200 comprises an outer liquid-impermeable layer (204), an inner liquid-permeable layer (202), and a superabsorbent layer (206) located between the outer and inner layers. In another embodiment, cover 600 includes a water-vapor-permeable layer (602) and a porous support layer (606) for supporting the water-vapor-permeable layer. In both of these embodiments, one or more corrosion inhibitors may be incorporated into the cover in one or more of the corresponding above-mentioned layers or in a layer separate from these layers, or may be provided in a separate container that fluidly communicates the corrosion inhibitor(s) to the microenvironment.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: February 27, 2007
    Assignee: Creare Inc.
    Inventors: Nabil A. Elkouh, Jeffrey J. Breedlove, Bruce R. Pilvelait
  • Publication number: 20070015035
    Abstract: A lightweight direct methanol fuel cell unit (20) comprising a fuel cell stack (24) enclosed within a housing (22). In one embodiment the fuel cell stack includes a plurality of polymer electrolyte membrane electrode assemblies (52) stacked alternatingly with a plurality of bipolar plates (48). Each bipolar plate includes a cathode flow field (78) defined by a porous cathode flow field structure (56) and an anode flow field (62) defined by an upper plate (58) and a lower plate (60) separated from one another by a plurality of spacers (64). The anode flow fields are manifolded with one another via manifold embossments (118, 120) that are hermetically sealed with one another with a gasket (126). The fuel cell stack and housing are shaped so as to form four manifold regions (36) in the spaces between the fuel cell stack and housing.
    Type: Application
    Filed: March 18, 2002
    Publication date: January 18, 2007
    Applicant: Creare Inc.
    Inventors: Michael Izenson, Christopher Crowley, Wayde Affleck
  • Patent number: 7100628
    Abstract: An electromechanically-assisted control system for use in a second-stage regulator. Regulator control assembly (20), also referred to as EMA assembly (20), includes a mechanical actuator sub-assembly (21) and an electromechanical actuator (EMA) sub-assembly (22) for controlling airflow through single air supply line (23). EMA sub-assembly (22) includes electronically controllable actuator (ECA) (34), which removably seals EMA orifice (36) in wall (30) of pilot chamber (32). ECA (34) is electrically connected with and controlled by control electronics (38). The control electronics include programmable microprocessor (40), which is electrically connected with charge and discharge electronics (42), both of which are electrically connected with power supply (44). Alternatively, regulator control assembly (20?), also referred to as all-electronic (AE) assembly (20?), has only an EMA sub-assembly and no mechanical actuator sub-assembly.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: September 5, 2006
    Assignee: Creare Inc.
    Inventors: Michael G. Izenson, Patrick J. Magari
  • Patent number: 7053012
    Abstract: A cover (200) for inhibiting corrosion of a metallic object over which the cover is placed. The cover has an inner surface (104) defined by a liquid-permeable layer (202) and an outer surface (102) defined by a liquid-impermeable layer (204). A moisture-absorbing layer (206) is sandwiched between the liquid-permeable layer and the liquid-impermeable layer. The liquid-permeable layer allows vapor and liquid moisture beneath the cover to be absorbed into the moisture-absorbing layer to reduce the amount of moisture beneath the cover. The liquid-impermeable layer repels environmental liquid moisture, such as rain, sea spray, dew and the like and prevents such moisture from penetrating the cover. A radar-influencing layer (308) and vapor corrosion inhibitors (214) may be included in the cover. A method of protecting an object is also disclosed. The method includes covering a metallic object with cover (200).
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: May 30, 2006
    Assignee: Creare Inc.
    Inventors: Nabil A. Elkouh, Bruce R. Pilvelait
  • Patent number: 6874676
    Abstract: A method and structure for welding an air-sensitive metal, such as titanium, in an ambient environment containing air. The method (10) includes forming a weld (12) through a weld-through coating (14) applied to the weld face(s) (28) and heat-affected zone (30) of one or more workpiece(s) (16) to be welded. The weld-through coating may contain a reactive material that comprises one or more halogenides of alkali metal, e.g., fluorides of barium, calcium, and strontium. The weld-through coating may be applied to the workpiece using a thermal-spray process, such as a plasma-spray process (32), prior to forming the weld. The weld-through coating may be applied to the workpiece(s) generally contemporaneously with the formation of the weld just ahead of the weld or may be applied at any time prior to forming the weld.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: April 5, 2005
    Assignee: Creare Inc.
    Inventors: Nabil A. Elkouh, Michael D. Jaeger, Stephen Luckowski
  • Publication number: 20050059306
    Abstract: A cover (200) for inhibiting corrosion of a metallic object over which the cover is placed. The cover has an inner surface (104) defined by a liquid-permeable layer (202) and an outer surface (102) defined by a liquid-impermeable layer (204). A moisture-absorbing layer (206) is sandwiched between the liquid-permeable layer and the liquid-impermeable layer. The liquid-permeable layer allows vapor and liquid moisture beneath the cover to be absorbed into the moisture-absorbing layer to reduce the amount of moisture beneath the cover. The liquid-impermeable layer repels environmental liquid moisture, such as rain, sea spray, dew and the like and prevents such moisture from penetrating the cover. A radar-influencing layer (308) and vapor corrosion inhibitors (214) may be included in the cover. A method of protecting an object is also disclosed. The method includes covering a metallic object with cover (200).
    Type: Application
    Filed: October 21, 2004
    Publication date: March 17, 2005
    Applicant: Creare Inc.
    Inventors: Nabil Elkouh, Bruce Pilvelait
  • Patent number: 6833334
    Abstract: A cover (200) for inhibiting corrosion of a metallic object over which the cover is placed. The cover has an inner surface (104) defined by a liquid-permeable layer (202) and an outer surface (102) defined by a liquid-impermeable layer (204). A moisture-absorbing layer (206) is sandwiched between the liquid-permeable layer and the liquid-impermeable layer. The liquid-permeable layer allows vapor and liquid moisture beneath the cover to be absorbed into the moisture-absorbing layer to reduce the amount of moisture beneath the cover. The liquid-impermeable layer repels environmental liquid moisture, such as rain, sea spray, dew and the like and prevents such moisture from penetrating the cover. A radar-influencing layer (308) and vapor corrosion inhibitors (214) may be included in the cover. A method of protecting an object is also disclosed. The method includes covering a metallic object with cover (200).
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: December 21, 2004
    Assignee: Creare Inc.
    Inventors: Nabil A. Elkouh, Bruce R. Pilvelait