Abstract: A nasal delivery device can include a nasal prong and an activation member. The nasal prong can have an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.

Abstract: A nasal delivery device can include air-receiving section that has a first passageway therethrough to allow air to pass through the air-receiving section, a powder-reservoir receiving section sized to receive a powder reservoir, and a powder-delivery section that has a second passageway therethrough to allow aerosolized powder from the powder reservoir to pass through the powder-delivery section. The first passageway can have a first end and a second end, with the first end being further from the powder-reservoir receiving section and the second end being at or near the powder-reservoir receiving area. The second end of the air-receiving section can include a flattened region so that air exiting the air-receiving section has a generally flattened profile.

Abstract: A nasal delivery device can include a nasal prong and an activation member. The nasal prong can comprises an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can be configured to detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.

Abstract: A rotary coolant adapter that is compatible with commercially available tool holders attaches to a rotary tool holder to supply coolant to a flow path in a rotary tool. The rotary coolant adapter has a stationary outer housing and a stationary supply tube for supplying coolant to an annular coolant manifold that surrounds a portion of the rotary tool holder. An internal radial feed tube supplies coolant from the annular coolant manifold to the flow path in the tool. Bearings support the stationary outer housing on the rotary coolant holder, and seals are located between the annular coolant manifold and the bearings to prevent coolant leakage from the annular manifold reaching the bearings.

Abstract: Aerosol delivery systems and methods for delivering an agent to a patient are described herein. In particular embodiments, an insulated receptacle is connected to a housing and holds a vial of an agent to be delivered to a patient. The vial is located in an inverted position within the receptacle. One or more reusable thermal packs can be located on the inner sides of the receptacle, to maintain a selected temperature surrounding the vial. The agent is administered to a patient by placing a prong into one of the patient's orifices and then activating an aerosol delivery system. Such systems can include jet aerosolization and pneumatic and ultrasonic nebulizers and preferably are portable.

Abstract: Cryogenic fluids are delivered along an axial path through a machine tool spindle to a cutting tool that is mounted in a standard tool holder. An external source of cryogen is delivered via an insulated line to a junction block housing where the cryogen flows into a vacuum insulated coolant delivery tube mounted on the axis of rotation of the spindle. The coolant delivery tube couples with a cryogenic manifold located in a standard tool holder in the end of the spindle. The cryogenic manifold couples the cryogen to a tool that is mounted in the tool holder. Before a tool change operation, the coolant delivery tube is raised to disconnect it from the cryogenic manifold, and to turn off the flow of cryogen to the delivery tube.

Abstract: An indirect cooling system for a rotating cutting tool uses a cryogenic coolant that is delivered to a cavity formed on the back surface of the cutting element, providing cooling near the cutting edge of the element. Because the total flow rate of the working fluid is low (less than 0.08 Liters/min/cutting edge), the fluid can be safely vented to atmosphere from the cavity, and as a result, no specialized coolant recovery or ventilation equipment is needed. The cavity may be formed with fins to enhance the heat transfer between the cutting element and the coolant, and coolant may additionally be sprayed directly onto the exterior surface of the element to cool the tool-chip interface. The indirect cooling system may be used for hard to machine metals and composites, as well as the machining of conventional materials without the use of traditional cutting fluids.

Abstract: A cutting tool having a cutting element such as an insert is cooled indirectly by a micro-channel heat exchanger that is mounted against the rear face of the insert. The heat exchanger is formed with an internal cavity that receives a coolant such as a cryogen. The cavity may include fins to enhance the removal of heat by the cryogen from the insert. Coolant inlet and outlet tubes are coupled to the interior of the heat exchanger to supply cryogen to the cavity. The flow rate of cryogen required to cool the insert during a given machining operation is less than one percent of the amount of standard coolant required to cool the same insert during the same machining operation.

Abstract: Aerosol delivery systems and methods for delivering an agent to a patient are described herein. The present invention includes embodiments comprising an insulated receptacle connected to a body to hold a vial of an agent to be delivered to a patient. The vial is located in an inverted position within the receptacle and connected to the housing. One or more reusable thermal packs can be located on the inner sides of the receptacle, to maintain a selected temperature surrounding the vial. The agent is administered to a patient by placing a prong into one of the patient's orifices and then activating an aerosol delivery system. Such systems comprise jet aerosolization and pneumatic and ultrasonic nebulizers and preferably are portable.

Abstract: The present invention is directed to a compact heat exchanger having a permeable heat transfer element. Fluid passes through the permeable element to passages which are provided at the interface between the permeable heat transfer element and a high thermal conductivity impervious element. Heat is transferred from the fluid to the permeable heat transfer element as the fluid flows through the permeable element. Heat is transferred to the impervious element from the permeable element and from the fluid as the fluid flows through the passages. Optionally a second fluid is in thermal communication with the impervious element.

Abstract: The present invention relates to a cyclic method and single pipe system for collecting and transferring heat energy from a periodic heat source to a thermal storage reservoir and preventing the back flow of such heat energy. The system is responsive to the temperature of the thermal storage reservoir and the availability of the heat source without reliance upon other external energy inputs or controls such as valves, pumps, floats, sensors, or electronic circuitry. During the heat collection stroke of the cycle an evaporator containing a volatile liquid generates a flow of vapor to a remote heat exchanger where the vapor gives up its latent heat of vaporization to the thermal storage reservoir thereby condensing. Condensate flows from the heat exchanger to an insulated pressure sustaining sump that efficiently accepts pulsatile fluid delivery.

Abstract: An apparatus for breaking and cutting rock and similar materials is provided with one or more roller cutter constructions, each comprising an annular cutter rotatably mounted in a housing. Impact forces are applied directly to the cutter intermittently with a reciprocable hammer. The cutter mountings are constructed to permit the impact force to drive the cutting edge of the cutter into rock while substantially isolating the cutter mountings from the hammer impact and rock reaction forces.