Abstract: Tissue needle for extracting a biopsy sample including a pistol style squeezable hand grip for single hand tissue needle operation during a biopsy procedure. A spring tensioned sliding cannula, including a configured cutting edge, is actuated by a squeeze trigger and cam arrangement to slide over a fixed position stylet for entry into a tissue sample area. A squeeze trigger manually cycles using one hand to obtain a biopsy sample contained in a tissue sample notch of the sharp stylet tip whereupon the tissue needle can then be manually withdrawn. The tissue needle can be left temporarily in position in the tissue sample area in preparation for additional sampling while the stylet is withdrawn independently of the cannula prior to other samplings after subsequent reinsertion of the stylet into the cannula.