Patents Assigned to CRESCENTA BIOSCIENCES
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Patent number: 12138243Abstract: A method for treating a viral disease in a subject comprising administering to said subject a therapeutically effective dose of one or more compounds that bind to fatty acid binding protein FABP4, with compounds described in the specification some having the general formula, Formula I-Formula XII, where W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R5 are as defined in the claims and description of embodiments. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.Type: GrantFiled: December 31, 2021Date of Patent: November 12, 2024Assignee: CRESCENTA BIOSCIENCESInventors: Emre Koyuncu, Hahn Kim, Gokhan Hotamisligil
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Patent number: 12084419Abstract: A novel class of compounds according to Formula I, II, or III, wherein W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments that bind to fatty acid binding protein FABP4 and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.Type: GrantFiled: June 28, 2021Date of Patent: September 10, 2024Assignee: CRESCENTA BIOSCIENCESInventors: Emre Koyuncu, Hahn Kim
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Publication number: 20230331673Abstract: A novel class of compounds according to Formula I, II, or III, wherein W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments that bind to fatty acid binding protein FABP4 and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.Type: ApplicationFiled: June 28, 2021Publication date: October 19, 2023Applicant: CRESCENTA BIOSCIENCESInventors: Emre KOYUNCU, Hahn Kim
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Publication number: 20230255933Abstract: A method for treating a viral disease in a subject comprising administering to said subject a therapeutically effective dose of one or more compounds that bind to fatty acid binding protein FABP4, with compounds described in the specification some having the general formula, Formula I-Formula XII, where W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.Type: ApplicationFiled: July 6, 2021Publication date: August 17, 2023Applicant: CRESCENTA BIOSCIENCESInventors: Emre KOYUNCU, Hahn KIM, Gokhan HOTAMISLIGIL
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Publication number: 20230241025Abstract: A method for treating a viral disease in a subject comprising administering to said subject a therapeutically effective dose of one or more compounds that bind to fatty acid binding protein FABP4, with compounds described in the specification some having the general formula, Formula I-Formula XII, where Wi - W4, Z1-Z4, Z1 - Z5, X, Y, n, and R1 - R8 are as defined in the claims and description of embodiments. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.Type: ApplicationFiled: December 31, 2021Publication date: August 3, 2023Applicant: CRESCENTA BIOSCIENCESInventors: Emre KOYUNCU, Hahn KIM, Gokhan Hotamisligil
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Publication number: 20230210837Abstract: A class of compounds that bind to FABP4 and inhibit viral replication in cells, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with an additional therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of viral diseases.Type: ApplicationFiled: December 31, 2021Publication date: July 6, 2023Applicant: CRESCENTA BIOSCIENCESInventors: Emre KOYUNCU, Hahn KIM, Gokhan Hotamisligil
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Publication number: 20230183179Abstract: A class of compounds that bind to fatty acid binding protein (FABP4) and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4.Type: ApplicationFiled: January 20, 2021Publication date: June 15, 2023Applicant: CRESCENTA BIOSCIENCESInventors: EMRE KOYUNCU, HAHN KIM
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Publication number: 20220313681Abstract: A class of compounds that bind to FABP4 and inhibit viral replication in cells, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with an additional therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of viral diseases.Type: ApplicationFiled: May 12, 2022Publication date: October 6, 2022Applicant: CRESCENTA BIOSCIENCESInventors: Emre KOYUNCU, Hahn KIM, Gokhan Hotamisligil
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Publication number: 20220002243Abstract: A novel class of compounds according to Formula I, II, or III, wherein W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments that bind to fatty acid binding protein FABP4 and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.Type: ApplicationFiled: June 28, 2021Publication date: January 6, 2022Applicant: CRESCENTA BIOSCIENCESInventors: EMRE KOYUNCU, HAHN KIM