Patents Assigned to CRESCENTA BIOSCIENCES
  • Patent number: 12138243
    Abstract: A method for treating a viral disease in a subject comprising administering to said subject a therapeutically effective dose of one or more compounds that bind to fatty acid binding protein FABP4, with compounds described in the specification some having the general formula, Formula I-Formula XII, where W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R5 are as defined in the claims and description of embodiments. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.
    Type: Grant
    Filed: December 31, 2021
    Date of Patent: November 12, 2024
    Assignee: CRESCENTA BIOSCIENCES
    Inventors: Emre Koyuncu, Hahn Kim, Gokhan Hotamisligil
  • Patent number: 12084419
    Abstract: A novel class of compounds according to Formula I, II, or III, wherein W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments that bind to fatty acid binding protein FABP4 and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: September 10, 2024
    Assignee: CRESCENTA BIOSCIENCES
    Inventors: Emre Koyuncu, Hahn Kim
  • Publication number: 20230331673
    Abstract: A novel class of compounds according to Formula I, II, or III, wherein W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments that bind to fatty acid binding protein FABP4 and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.
    Type: Application
    Filed: June 28, 2021
    Publication date: October 19, 2023
    Applicant: CRESCENTA BIOSCIENCES
    Inventors: Emre KOYUNCU, Hahn Kim
  • Publication number: 20230255933
    Abstract: A method for treating a viral disease in a subject comprising administering to said subject a therapeutically effective dose of one or more compounds that bind to fatty acid binding protein FABP4, with compounds described in the specification some having the general formula, Formula I-Formula XII, where W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.
    Type: Application
    Filed: July 6, 2021
    Publication date: August 17, 2023
    Applicant: CRESCENTA BIOSCIENCES
    Inventors: Emre KOYUNCU, Hahn KIM, Gokhan HOTAMISLIGIL
  • Publication number: 20230241025
    Abstract: A method for treating a viral disease in a subject comprising administering to said subject a therapeutically effective dose of one or more compounds that bind to fatty acid binding protein FABP4, with compounds described in the specification some having the general formula, Formula I-Formula XII, where Wi - W4, Z1-Z4, Z1 - Z5, X, Y, n, and R1 - R8 are as defined in the claims and description of embodiments. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.
    Type: Application
    Filed: December 31, 2021
    Publication date: August 3, 2023
    Applicant: CRESCENTA BIOSCIENCES
    Inventors: Emre KOYUNCU, Hahn KIM, Gokhan Hotamisligil
  • Publication number: 20230210837
    Abstract: A class of compounds that bind to FABP4 and inhibit viral replication in cells, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with an additional therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of viral diseases.
    Type: Application
    Filed: December 31, 2021
    Publication date: July 6, 2023
    Applicant: CRESCENTA BIOSCIENCES
    Inventors: Emre KOYUNCU, Hahn KIM, Gokhan Hotamisligil
  • Publication number: 20230183179
    Abstract: A class of compounds that bind to fatty acid binding protein (FABP4) and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4.
    Type: Application
    Filed: January 20, 2021
    Publication date: June 15, 2023
    Applicant: CRESCENTA BIOSCIENCES
    Inventors: EMRE KOYUNCU, HAHN KIM
  • Publication number: 20220313681
    Abstract: A class of compounds that bind to FABP4 and inhibit viral replication in cells, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with an additional therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of viral diseases.
    Type: Application
    Filed: May 12, 2022
    Publication date: October 6, 2022
    Applicant: CRESCENTA BIOSCIENCES
    Inventors: Emre KOYUNCU, Hahn KIM, Gokhan Hotamisligil
  • Publication number: 20220002243
    Abstract: A novel class of compounds according to Formula I, II, or III, wherein W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments that bind to fatty acid binding protein FABP4 and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.
    Type: Application
    Filed: June 28, 2021
    Publication date: January 6, 2022
    Applicant: CRESCENTA BIOSCIENCES
    Inventors: EMRE KOYUNCU, HAHN KIM