Patents Assigned to Crescita Therapeutics Inc.
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Publication number: 20230381102Abstract: The present application relates to a rinse-off composition comprising an oil phase and an aqueous surfactant matrix, wherein one or more active agents are dissolved in one or more non-polar, water-immiscible solvents, and the oil phase is dispersed in the aqueous surfactant matrix. The present application also relates to methods of delivering the active agent(s) to a subject in need thereof topically, for example to the skin, the hair, and scalp. The present application also relates to use of the rinse-off compositions to treat and/or prevent topical conditions such as dermatitis and psoriasis. In some embodiments, the rinse-off compositions of the present application are shampoo compositions.Type: ApplicationFiled: August 3, 2023Publication date: November 30, 2023Applicant: CRESCITA THERAPEUTICS INC.Inventors: Gary Robert KELM, Wade HULL, Carolyn Shawn MURPHY
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Patent number: 11642356Abstract: In one example presented herein, is a pharmaceutical composition. The pharmaceutical composition can include halobetasol propionate, from 0 wt % to 3 wt % ethoxylated castor oil, a first compound, and a second compound. The first compound and the second compound can be selected from; N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate. The first compound and the second compound are not the same.Type: GrantFiled: October 21, 2016Date of Patent: May 9, 2023Assignee: Crescita Therapeutics Inc.Inventors: Wade Hull, Ngoc Truc-Chi Vo, Dominic King-Smith
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Publication number: 20220160661Abstract: Methods of applying a solid forming local anesthetic formulations can include applying a layer of a solid-forming formulation to a skin surface, wherein the solid-forming local anesthetic formulation includes from 4 wt % to 30 wt % of a local anesthetic, less than 36 wt % dicalcium phosphate, water, and a polymer. These methods can further include maintaining the layer of the formulation on the skin surface for a period of time sufficient to allow the layer of the formulation to transition from a semi-solid to a cohesive film and to topically deliver the local anesthetic to the skin surface, and removing the layer of the formulation from the skin surface by peeling the layer of the formulation off the skin surface. The layer of the formulation can be operable to be removed as a single piece or two to three large pieces.Type: ApplicationFiled: February 11, 2022Publication date: May 26, 2022Applicant: Crescita Therapeutics Inc.Inventors: Jie Zhang, Wade Hull, Ngoc Truc-Chi Vo
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Publication number: 20210169800Abstract: The present application relates to a rinse-off composition comprising an oil phase and an aqueous surfactant matrix, wherein one or more active agents are dissolved in one or more non-polar, water-immiscible solvents, and the oil phase is dispersed in the aqueous surfactant matrix. The present application also relates to methods of delivering the active agent(s) to a subject in need thereof topically, for example to the skin, the hair, and scalp. The present application also relates to use of the rinse-off compositions to treat and/or prevent topical conditions such as dermatitis and psoriasis. In some embodiments, the rinse-off compositions of the present application are shampoo compositions.Type: ApplicationFiled: February 5, 2021Publication date: June 10, 2021Applicant: CRESCITA THERAPEUTICS INC.Inventors: Gary Robert KELM, Wade HULL, Carolyn Shawn MURPHY
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Patent number: 10945952Abstract: The present application relates to a rinse-off composition comprising an oil phase and an aqueous surfactant matrix, wherein one or more active agents are dissolved in one or more non-polar, water-immiscible solvents, and the oil phase is dispersed in the aqueous surfactant matrix. The present application also relates to methods of delivering the active agent(s) to a subject in need thereof topically, for example to the skin, the hair, and scalp. The present application also relates to use of the rinse-off compositions to treat and/or prevent topical conditions such as dermatitis and psoriasis. In some embodiments, the rinse-off compositions of the present application are shampoo compositions.Type: GrantFiled: March 16, 2020Date of Patent: March 16, 2021Assignee: CRESCITA THERAPEUTICS INC.Inventors: Gary Robert Kelm, Wade Hull, Carolyn Shawn Murphy
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Publication number: 20200338026Abstract: Solid-forming topical formulations can include a local anesthetic, an emulsifying agent, polymer, and water. The formulation can include from 0.1 wt % to 5 wt % more of the emulsifying agent, from 0.1 wt % to 20 wt % more of the polymer, and from 0.1 wt % to 30 wt % more water than a comparative formulation, and drying time is faster than the comparative formulation when applied to a skin surface and dried under the same ambient conditions.Type: ApplicationFiled: July 15, 2020Publication date: October 29, 2020Applicant: Crescita Therapeutics Inc.Inventors: Jie Zhang, Wade Hull, Ngoc Truc-Chi Vo
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Publication number: 20200289415Abstract: The present application relates to a rinse-off composition comprising an oil phase and an aqueous surfactant matrix, wherein one or more active agents are dissolved in one or more non-polar, water-immiscible solvents, and the oil phase is dispersed in the aqueous surfactant matrix. The present application also relates to methods of delivering the active agent(s) to a subject in need thereof topically, for example to the skin, the hair, and scalp. The present application also relates to use of the rinse-off compositions to treat and/or prevent topical conditions such as dermatitis and psoriasis. In some embodiments, the rinse-off compositions of the present application are shampoo compositions.Type: ApplicationFiled: March 16, 2020Publication date: September 17, 2020Applicant: CRESCITA THERAPEUTICS INC.Inventors: Gary Robert KELM, Wade HULL, Carolyn Shawn MURPHY
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Patent number: 10751305Abstract: Solid-forming topical formulations can include a local anesthetic, an emulsifying agent, polymer, and water. The formulation can include from 0.1 wt % to 5 wt % more of the emulsifying agent, from 0.1 wt % to 20 wt % more of the polymer, and from 0.1 wt % to 30 wt % more water than a comparative formulation, and drying time is faster than the comparative formulation when applied to a skin surface and dried under the same ambient conditions.Type: GrantFiled: July 20, 2017Date of Patent: August 25, 2020Assignee: Crescita Therapeutics Inc.Inventors: Jie Zhang, Wade Hull, Ngoc Truc-Chi Vo
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Patent number: 10603293Abstract: Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.Type: GrantFiled: June 14, 2018Date of Patent: March 31, 2020Assignee: Crescita Therapeutics Inc.Inventor: Jie Zhang
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Publication number: 20190255070Abstract: In one example presented herein, is a pharmaceutical composition. The pharmaceutical composition can include halobetasol propionate, from 0 wt % to 3 wt % ethoxylated castor oil, a first compound, and a second compound. The first compound and the second compound can be selected from; N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate. The first compound and the second compound are not the same.Type: ApplicationFiled: October 21, 2016Publication date: August 22, 2019Applicant: Crescita Therapeutics Inc.Inventors: Wade HULL, Ngoc True-Chi VO, Dominic KING-SMITH
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Patent number: 10350180Abstract: Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.Type: GrantFiled: June 5, 2017Date of Patent: July 16, 2019Assignee: Crescita Therapeutics Inc.Inventor: Jie Zhang
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Publication number: 20180289644Abstract: Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.Type: ApplicationFiled: June 14, 2018Publication date: October 11, 2018Applicant: Crescita Therapeutics Inc.Inventor: Jie Zhang
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Publication number: 20180125802Abstract: Solid-forming topical formulations can include a local anesthetic, an emulsifying agent, polymer, and water. The formulation can include from 0.1 wt % to 5 wt % more of the emulsifying agent, from 0.1 wt % to 20 wt % more of the polymer, and from 0.1 wt % to 30 wt % more water than a comparative formulation, and drying time is faster than the comparative formulation when applied to a skin surface and dried under the same ambient conditions.Type: ApplicationFiled: July 20, 2017Publication date: May 10, 2018Applicant: Crescita Therapeutics Inc.Inventors: Jie Zhang, Wade Hull, Ngoc Truc-Chi Vo
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Patent number: 9693976Abstract: Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.Type: GrantFiled: January 14, 2011Date of Patent: July 4, 2017Assignee: Crescita Therapeutics Inc.Inventor: Jie Zhang
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Patent number: 9675562Abstract: The present disclosure is drawn to an adhesive peel-forming formulation for dermal delivery of a drug, comprising a drug, a solvent vehicle, and a polymer peel-forming agent. The solvent vehicle can comprise a volatile solvent system comprising one or more volatile solvent, and a non-volatile solvent system comprising two or more non-volatile solvents. The non-volatile solvent system can have a solubility with respect to the drug that is within a window of operable solubility such that the drug is deliverable at therapeutically effective rates over a sustained period of time.Type: GrantFiled: November 5, 2014Date of Patent: June 13, 2017Assignee: Crescita Therapeutics Inc.Inventors: Jie Zhang, Kevin S. Warner, Michael A. Ashburn, Larry D. Rigby, Suyi Niu
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Patent number: 9642912Abstract: The present disclosure is drawn to topical formulations and related methods. In one embodiment, a topical formulation is provided that includes at least one corticosteroid, a first compound, and a second compound. The first compound and second compound are different and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate.Type: GrantFiled: December 22, 2014Date of Patent: May 9, 2017Assignee: Crescita Therapeutics Inc.Inventors: Edward T. Kisak, John M. Newsam, Dominic King-Smith, Pankaj Karande, Samir Mitragotri, Wade A. Hull, Ngoc Truc-Chi Vo