Patents Assigned to Crestone, Inc.
  • METHODS AND COMPOUNDS FOR TREATMENT OF AUTISM SPECTRUM DISORDER
    Publication number: 20240000756
    Abstract: Methionyl tRNA synthetase inhibitors (MetRS) are provided for use in therapy as antibacterial agents in autism spectrum disorder.
    Type: Application
    Filed: December 8, 2021
    Publication date: January 4, 2024
    Applicant: Crestone, Inc.
    Inventors: Nebojsa Janjic, Urs Ochsner
  • Antimycobacterial heterocyclic amides
    Patent number: 11655225
    Abstract: The present invention provides novel heterocylic amide compounds having useful antimycobacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: May 23, 2023
    Assignee: CRESTONE, INC.
    Inventors: Joshua Day, James Graham, Thale Jarvis, Elizabeth Mcfaddin, Urs Ochsner, Xicheng Sun, Christina Wong
  • Substituted phenylether-thienopyridone compounds with antibacterial activity
    Patent number: 8697720
    Abstract: Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side phenylether constituent and a right hand side thienopyridone constituent. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: April 15, 2014
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Xicheng Sun, Nebojsa Janjic, Sarah Strong
  • Methods and compounds for treatment of clostridium based infection
    Patent number: 8658670
    Abstract: Methionyl tRNA synthetase inhibitors (MetRS) are provided for use in therapy as antibacterial agents in Clostridium based infection.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: February 25, 2014
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Xicheng Sun, Nebojsa Janjic, Sarah Strong
  • Antibacterial sulfone and sulfoxide substituted heterocyclic urea compounds
    Patent number: 8293919
    Abstract: The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: October 23, 2012
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun, Jian Qiu, John C. Rohloff
  • Antibacterial amide and sulfonamide substituted heterocyclic urea compounds
    Patent number: 8148380
    Abstract: The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: April 3, 2012
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun, Jian Qiu, John C. Rohloff
  • Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds
    Publication number: 20120015941
    Abstract: The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.
    Type: Application
    Filed: July 23, 2008
    Publication date: January 19, 2012
    Applicant: CRESTONE, INC.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun, Jian Qiu, John C. Rohloff
  • Substituted thienopyridone compounds with antibacterial activity
    Patent number: 7994192
    Abstract: Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side chroman group or left hand side tetrahydroquinoline group and a right hand side thienopyridone group. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: August 9, 2011
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Xicheng Sun, Nebojsa Janjic, Sarah Strong
  • Enantiomeric compounds with antibacterial activity
    Patent number: 7973050
    Abstract: Novel compounds in enantiomeric excess that are inhibitors of bacterial methionyl synthetase (MetRS) are disclosed. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, and in particular their use in therapy for Clostridium difficile infection.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: July 5, 2011
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Xicheng Sun, Nebojsa Janjic, Sarah Strong, Albert Charles Gyorkos
  • Antibacterial Sulfone and Sulfoxide Substituted Heterocyclic Urea Compounds
    Publication number: 20100286169
    Abstract: The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided.
    Type: Application
    Filed: July 23, 2008
    Publication date: November 11, 2010
    Applicant: CRESTONE, INC.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun, Jian Qiu, John C. Rohloff