Abstract: Described herein are methods and systems for generating a mobile device-specific identifier usable across native mobile applications and mobile browsers with a unified opt-out mechanism. A mobile device generates a transient identifier for the mobile device and maps the transient identifier to a stable identifier of the mobile device using at least one call to a service endpoint coupled to the mobile device via a communications network. A browser application on the mobile device renders a webpage, the webpage comprising first instructions, executed by the browser application, to retrieve the stable identifier of the mobile device using at least one call to the service endpoint coupled to the mobile device via a communications network.

Abstract: A computer receives a request for graphical display source code for a computerized graphical advertisement display, and retrieves seed animations including a plurality of seed animation features. The computer generates candidate animations based on the one or more seed animations, where the computer alters a first aspect of a seed animation to generate an altered seed animation having a plurality of altered seed animation features and the computer alters a second aspect of the altered seed animation to generate a candidate animation having a plurality of candidate animation features. The computer generates candidate animation scores based upon a context of the advertisement display and the plurality of candidate animation features. The computer selects an animation from the candidate animations based on the candidate animation scores and generates the graphical display source code based on the selected animation, a size of the advertisement display, and display capabilities of the user device.

Abstract: The invention provides compositions and methods for effective lysosomal targeting mediated by PCSK9. In particular, the compositions and methods provided by the invention may be used to treat lysosomal storage diseases such as Pompe Disease and Sanfilippo Syndrome Type B, and they may be used for targeting lysosomal enzymes to the various muscles of the human body.

Abstract: Described herein are methods and systems for generating a mobile device-specific identifier usable across native mobile applications and mobile browsers with a unified opt-out mechanism. A mobile device generates a transient identifier for the mobile device and maps the transient identifier to a stable identifier of the mobile device using at least one call to a service endpoint coupled to the mobile device via a communications network. A browser application on the mobile device renders a webpage, the webpage comprising first instructions, executed by the browser application, to retrieve the stable identifier of the mobile device using at least one call to the service endpoint coupled to the mobile device via a communications network.

Abstract: Systems and methods for the semantic modeling of advertising creatives included in targeted search advertising campaigns in accordance with embodiments of the invention are disclosed. In one embodiment, an advertising creative generation device includes a processor, an advertising creative generation application, at least one semantic model and performance data, wherein the an advertising creative generation application configures the processor to obtain a set of existing advertising creatives, where at least one of the existing advertising creatives comprises an existing concept, identify at least one existing advertising strategy pattern, determine performance data for the at least one existing advertising strategy pattern based on the performance data, identify at least one performance pattern based on the performance data for the at least one existing advertising strategy pattern, and generate at least one recommended advertising strategy.

Abstract: Interaction-based pricing of electronic ads is disclosed. An indication is received of a first interaction by an individual with an advertiser at least in part via an electronic advertisement that has been displayed to the individual. The electronic advertisement provides two or more distinct interactions the individual could elect to have at least in part via the advertisement and each of the two or more distinct interactions has associated with it a corresponding interaction-specific value to the advertiser. The advertiser is charged, in response to the indication, an interaction-specific amount associated with the first interaction.