Abstract: An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70° and 90° with respect to the injection axis (B).

Abstract: A needleless injection device includes a body forming a receptacle extending axially from an upper radial seat along an injection axis, a gas generator, a tubular reservoir containing an active ingredient and extending axially in the receptacle from an upper end to a lower end, and a nozzle for injecting the active ingredient. The nozzle is arranged at the lower end of the reservoir and has an outer thread to be screwed onto a complementary thread formed by the body. The external thread of the nozzle has an overall triangular cross-section and is delimited by an upper face, which has a first angle with respect to a radial axis perpendicular to the injection axis, and a lower face, which has a second angle with respect to the radial axis. The first angle is greater than the second angle.

Abstract: A needleless injection device is provided that includes a body forming a housing, a gas generator, a tubular reservoir that contains an active ingredient, and a T-shaped elastically deformable membrane having a tubular portion. The reservoir extends axially in the housing from an upper end to a lower end and the tubular portion is configured to extend and lie axially in the reservoir under an effect of a pressure generated by the gas generator. An injection nozzle is arranged at the lower end of the reservoir. The tubular portion is funnel shaped and includes at least an upper segment that decreases along an axial elongation direction of the member and a lower segment that increases along the axial elongation direction. The axial length of the upper segment is greater than that of the lower segment.

Abstract: The present disclosure concerns a needleless injection device including a body forming a housing, a gas generator, a tubular reservoir which contains an active ingredient to be injected, and a generally T-shaped elastically deformable membrane. The membrane includes a tubular portion which extends axially in the reservoir and is designed to lie axially in the reservoir under the effect of the pressure generated by the gas generator. A nozzle for injecting the active ingredient is arranged at the lower end of the reservoir. The device further includes a sock which wraps the tubular portion of the membrane, at least partially. The sock is adapted to limit the friction between the tubular portion of the membrane and the reservoir.

Abstract: The present disclosure relates to a needleless injector including a cap, an injection system, a body, a gas generator, and a percussion device. The body is covered by the cap and is mounted to slide relative to the cap. The percussion device includes a striker that is slidingly mounted along a sliding axis between a rest position and a percussion position and a lock mechanism. The lock mechanism includes a lug and a retention tab. The lug projects from a peripheral face of the striker along an axis that is perpendicular to the sliding axis and has a first support ramp. The retention tab is attached to the cap, and has a second support ramp. The ramps are configured to move the retention tab radially when pushed by the striker from a retaining position to a release position and the retention tab is moved aside to release the striker.

Abstract: The present disclosure relates to a needleless injector including a cap, an injection system, a body, and a compression spring. The body is mounted to slide upwards in relation to the cap along an injection axis between a rest position and an injection position. The compression spring is axially intercalated along the injection axis between the body and the cap to compress the skin tissue of the user when the nozzle is applied to the skin. The compression spring is a frustroconical helical spring that extends along the injection axis and includes a plurality of turns designed to nest axially one inside the other.

Abstract: The present disclosure is directed towards a needleless injection device that includes a body, a gas generator, an injection system that extends axially along an injection axis and includes at least one plunger, an active ingredient reservoir, an injection nozzle that delimits at least one injection channel, a cover that houses the body of the device, a removable cap that protects a lower downstream end of the injection nozzle, a stopper that houses the cap, and a blocking element. The stopper is pivotally mounted about the injection axis between a closed position in which the stopper is locked on the injection device and an open position in which the stopper is unlocked from the injection device. The blocking element is radially interposed between the cap and the stopper, and is configured to block, by friction, the relative pivoting of the cap and of the stopper, about the injection axis.

Abstract: The present disclosure is directed towards a needleless injection device including an injection system which includes at least one injection nozzle which delimits at least one injection channel, and which is axially delimited by an upper face arranged facing the lower face of the reservoir, and a lower face adapted to cooperate with a cap, and an upper sealing gasket which extends around the at least one channel and which is housed in an upper groove formed on the upper face of the nozzle, and the upper gasket has a wave-shaped radial section which comprises successively, along a radial direction, a recessed portion and a bump portion, said bump portion being adapted to be lying toward the recessed portion provided to this end, under the effect of the axial pressure exerted by the lower face of the reservoir on said sealing gasket.

Abstract: Needleless injection device (1) comprising a gas generator (2), a reservoir (5) in the form of a glass tube (6) closed by an upstream stopper (7) and a downstream stopper (8) between which a liquid active principle (9) is accommodated, and an injection nozzle (15) equipped with a receptacle (19) and with at least one peripheral injection conduit (20), said tube (6) having, at one of its ends, a flange (4) via which it is in contact with said nozzle (15). The main feature of this needleless injection device (1) is that the tube (6) has a cylindrical inner channel with an upstream part (21) which is continued by a downstream part (22) of smaller diameter, said downstream part (22) being surrounded by said flange (4) and opening into the receptacle (19).

Abstract: The present invention relates to a needleless injection device (1) comprising a reservoir (3), obturated by an upstream stopper (4) and a downstream stopper (5) between which a liquid active principle (6) is accommodated, and a receptacle (7) comprising at least one injection conduit (8), said receptacle comprising a cavity (10) whose height is equal to the distance traveled by the downstream stopper before each injection conduit is opened, —the height of the cavity in millimeters being between a minimum height and a maximum height, respectively defined by the following relationships, •minimum height=3, •maximum height=15×exp. (?(V/9)2)+10, where V is the initial speed of ascent of the pressure profile expressed in bar per microsecond, —the ratio between the length of each injection conduit and the height of the cavity being between 1 and 2.

Abstract: The technical field of the invention is that of needleless pre-filled disposable syringes, operating with a gas generator, and used for intradermal, subcutaneous and intramuscular injections, of a liquid active principle for therapeutic use in human and veterinary medicine. The inventive needleless syringes use a reservoir (5) consisting of a tube (6) closed by an upstream plug-piston (7) and a downstream plug-piston (8) between which is contained the liquid active principle. Said needleless syringes are characterized in that they are capable of injecting a variable amount of liquid active principle (9) by adapting, through displacement of the downstream plug-piston (8) in the tube (6) the volume included between the two plug-pistons (7,8) to the amount of active principle (9) to be injected.

Abstract: A needleless injection device used for intradermal, subcutaneous and intramuscular injections is disclosed. The device includes a pyrotechnic gas generator, at least one piston, a reserve of liquid active principle and an injection nozzle. The generator includes a pyrotechnic charge composed of a central energetic material that is surrounded by a second peripheral energetic material. The entire outer surface of the central energetic material contacts the inner surface of the peripheral energetic material. The two energetic materials have different rates of combustion.

Abstract: The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container (3) closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore (10) in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore (10) of the receptacle.

Abstract: Needleless injection device (1) comprising a gas generator (2), a reservoir (5) in the form of a glass tube (6) closed by an upstream stopper (7) and a downstream stopper (8) between which a liquid active principle (9) is accommodated, and an injection nozzle (15) equipped with a receptacle (19) and with at least one peripheral injection conduit (20), said tube (6) having, at one of its ends, a flange (4) via which it is in contact with said nozzle (15). The main feature of this needleless injection device (1) is that the tube (6) has a cylindrical inner channel with an upstream part (21) which is continued by a downstream part (22) of smaller diameter, said downstream part (22) being surrounded by said flange (4) and opening into the receptacle (19).

Abstract: The present invention relates to a needleless injection device (1) comprising a reservoir (3), obturated by an upstream stopper (4) and a downstream stopper (5) between which a liquid active principle (6) is accommodated, and a receptacle (7) comprising at least one injection conduit (8), said receptacle comprising a cavity (10) whose height is equal to the distance travelled by the downstream stopper before each injection conduit is opened, —the height of the cavity in millimetres being between a minimum height and a maximum height, respectively defined by the following relationships, •minimum height=3, •maximum height=15×exp. (?(V/9)2)+10, where V is the initial speed of ascent of the pressure profile expressed in bar per microsecond, —the ratio between the length of each injection conduit and the height of the cavity being between 1 and 2.

Abstract: The invention relates to an injection device which may or may not be equipped with a needle, comprising an injection nozzle and a tube which is intended to receive the active substance to be injected, whereby the tube is fixed to the nozzle using connecting means. The inventive device is characterized in that the aforementioned connecting means comprise at least three identical bosses which are solidly connected to the nozzle. Moreover, each of said bosses comprises an inclined part which terminates in a flange, said flange co-operating with a collar which is formed on the tube and acts as a backstop for the tube when the latter is connected to the nozzle.

Abstract: The invention concerns the field of pre-filled and disposable needleless syringes, operating with a gas generator and used for intradermal, subcutaneous and intramuscular injections of a liquid active principle for therapeutic purposes in human and veterinary medicine. Said injection device (1) is mainly characterized in that it has a free pressuring space (26) around the reservoir (20) of the active principle (17) so that the gases produced by the gas generator (4) instantly penetrate said pressurizing space (26), compressing said reservoir (20) just before causing the plunger to move (18) to expel the liquid active principle (17). During said displacement, the reservoir (20) is subjected to a state of equal pressure.

Abstract: The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurized for injection.

Abstract: The invention relates to a method of assembling a needleless injection device (1), whereby a plurality of elements forming a circuit of elements is assembled to a body (2). The aforementioned circuit comprises elements such as an initiation device, a receptacle (5) containing an active agent to be injected, and an active agent injection system. The inventive method is characterised in that it comprises a step in which a gas-generating cartridge (6), which is adapted to the nature and/or quantity of active agent to be injected as well as to the skin penetration depth desired for same, is inserted directly into the circuit of elements, independently of said elements, from outside the body (2). The invention also relates to a needleless injection device (1).

Abstract: The invention relates to a needleless injection device (1) comprising a body (2) which supports and/or defines a plurality of elements that form a circuit of elements. The aforementioned circuit comprises, from upstream towards downstream, an initiation device which is associated with a pyrotechnic gas generator, a receptacle (5) housing a liquid active agent that is to be injected, and an active agent injection system. According to the invention, the pyrotechnic gas generator comprises a pyrotechnic charge (62) which is placed in a combustion chamber (4). The inventive device is characterised in that it comprises at least one device for regulating the gas pressure level in the combustion chamber (4).