Patents Assigned to Cryolife, Inc.
  • Publication number: 20190290481
    Abstract: Apparatus and methods for accomplishing fluid drainage and localized cooling of the central nervous system broadly encompassing an intrathecal catheter assembly accomplishing drainage and cooling, and a console apparatus that may contain control, cooling, and drainage subsystems, and use thereof.
    Type: Application
    Filed: March 22, 2019
    Publication date: September 26, 2019
    Applicant: CryoLife, Inc.
    Inventors: Adam William Martinez, Rachel Candace Howell, Emily Renee Croft, Jeremy Gura, Alejandro A. Aviles
  • Patent number: 9278172
    Abstract: A connector for fluidly coupling proximal and distal tubular segments of a fluid conduit is provided. In one embodiment, the connector can include a connector body having an outer surface defining a first outer perimeter and an inner surface defining a lumen. The connector can also include a connecting device having an open configuration and a plurality of closed configurations. The connecting device can include first and second members configured to engage each other to secure the fluid conduit to the connector. The connecting device can also include a plurality of closed configurations for securing fluid conduits of different sizes.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: March 8, 2016
    Assignee: CRYOLIFE, INC.
    Inventor: Judson A. Herrig
  • Publication number: 20150051532
    Abstract: Systems and methods for a blood conduit for fluidly coupling a first vascular segment to a second vascular segment are disclosed herein. In one embodiment, a system for fluidly coupling proximal and distal tubular segments of a fluid conduit in a cardiovascular system is provided. The system may include a first engagement feature disposed on a distal end of the proximal tubular segment. The system also may include a second engagement feature disposed on a proximal end of the distal tubular segment. The first engagement feature may be configured to mate with the second engagement feature. In this manner, continuous flow may be provided between the proximal and distal tubular segments of the fluid conduit. In another embodiment, the proximal and distal tubular segments of the fluid conduit may collectively form a single unitary lumen without a connection device interposed between the segments.
    Type: Application
    Filed: August 4, 2014
    Publication date: February 19, 2015
    Applicant: CRYOLIFE, INC.
    Inventors: Daniel Tomko, David Gale, Stacy Arnold, Venkata Katragadda
  • Patent number: 8883408
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: November 11, 2014
    Assignee: CryoLife, Inc.
    Inventors: Joseph Hamby, Steven Walsh
  • Publication number: 20140271904
    Abstract: A method is provided for preparing a biological tissue for implantation. The method includes providing a biological tissue from a human or animal donor, treating the biological tissue with an antiviral treatment formulation, lysing the biological tissue, decellularizing the biological tissue with a decellularization treatment formulation, and decontaminating the biological tissue with an alkaline alcohol solution. The antiviral treatment formulation may include a solution of peracetic acid and an alcohol, wherein the peracetic acid is present in the antiviral treatment formulation at a concentration from about 0.03% to about 1.2% (v/v). The decellularization solution may include a solution of a polar aprotic solvent, such as dimethyl sulfoxide, benzyl alcohol and ethanol.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Applicant: CryoLife, Inc.
    Inventors: Joseph Hamby, Steven Goldstein, Valerie Rohde
  • Publication number: 20140180190
    Abstract: An apparatus and method are provided to treat a stenosis. A delivery device is provided that has an elongate tubular member coupled therewith. The elongate tubular member has an outside surface that is configured to prevent adherence of in vivo matter. The tubular member has a proximal end and a distal end and is reinforced along its length to maintain open lumen under a transverse load. The tubular member is placed in the vasculature such that the distal end of the elongate tubular member is disposed distal of a stenosis. The proximal end of the elongate tubular member is disposed inside the vessel, preferably at a location proximal of the stenosis. Thereafter, after a therapeutic period, the elongate tubular member is removed intact.
    Type: Application
    Filed: February 27, 2014
    Publication date: June 26, 2014
    Applicant: CryoLife, Inc.
    Inventors: Mitchell Dann, Judson A. Herrig, Stephen Hohmann
  • Patent number: 8475827
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: July 2, 2013
    Assignee: CryoLife, Inc.
    Inventors: Joseph Hamby, Steven Walsh, Al Heacox, Steven Goldstein, David Gale, Stacy Arnold, Ann Sands Updegrove
  • Publication number: 20130142844
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicant: CRYOLIFE, INC.
    Inventor: CRYOLIFE, INC.
  • Patent number: 8377143
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: February 19, 2013
    Assignee: CryoLife, Inc.
    Inventors: Joseph Hamby, Steven Walsh
  • Publication number: 20120009679
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 12, 2012
    Applicant: CRYOLIFE, INC.
    Inventors: Joseph Hamby, Steven Walsh
  • Publication number: 20120009644
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material with water or a hypotonic solution to lyse native cells of the tissue material, treating the tissue material in a nuclease-containing solution which includes an antimicrobial, treating the tissue material with an alkaline alcohol solution, treating the tissue material with a chlorine dioxide treatment solution, and sterilizing the tissue material.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 12, 2012
    Applicant: CRYOLIFE, INC.
    Inventors: Joseph Hamby, Steven Walsh, Al Heacox, Steven Goldstein, David Gale, Stacy Arnold, Ann Sands Updegrove
  • Publication number: 20120010725
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 12, 2012
    Applicant: CRYOLIFE, INC.
    Inventors: Joseph Hamby, Steven Walsh, Al Heacox, Steven Goldstein, David Gale, Stacy Arnold, Ann Sands Updegrove
  • Patent number: 8071124
    Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: December 6, 2011
    Assignee: CryoLife, Inc.
    Inventors: K. Umit Yuksel, Ana T. Bird, Kirby S. Black
  • Patent number: 8057818
    Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: November 15, 2011
    Assignee: CryoLife, Inc.
    Inventors: K. Umit YĆ¼ksel, Ana T. Bird, Kirby S. Black
  • Publication number: 20110208238
    Abstract: A delivery tip extension communicates an adhesive material from a fluid applicator tip to a site within a patient. The delivery tip extension has an elongated shaft with a proximal end portion, a central body portion, and a tapered distal end portion. The central body portion has a length between about 5 cm and about 45 cm. A lumen is defined within and extends along the elongated shaft from a proximal opening to a distal opening. The elongated shaft is relatively more rigid along the central body portion than along the distal end portion to facilitate driving the elongated shaft through the patient with reduced trauma to the patient by the distal end portion. The lumen is sized and shaped along the proximal end portion for securely receiving the fluid applicator tip inserted through the proximal opening such that a dispensing outlet on the fluid applicator tip is in fluid communication with the lumen. The delivery tip extension is sterilized or sterilizable.
    Type: Application
    Filed: February 23, 2011
    Publication date: August 25, 2011
    Applicant: CRYOLIFE, INC.
    Inventor: Jeffrey Michael Hoffman
  • Patent number: 7896920
    Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: March 1, 2011
    Assignee: CryoLife, Inc.
    Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
  • Publication number: 20100285587
    Abstract: A method of preparing a tissue graft material is disclosed. The disclosure also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.
    Type: Application
    Filed: July 23, 2010
    Publication date: November 11, 2010
    Applicant: CRYOLIFE, INC.
    Inventors: Jeremy D. Ollerenshaw, Steven Goldstein, Kirby S. Black
  • Publication number: 20100233669
    Abstract: An antibiotic composition is provided for use in decontaminating biological tissue, for example, graft tissues for transplantation or preparation for terminal sterilization. The antibiotic composition is a physiological solution includes a lantibiotic, such as nisin. The antibiotic solution is effective to substantially inhibit bacterial growth of at least one type of gram-positive bacteria while substantially maintaining the physiological characteristics of the tissue. The method may include contacting the tissue with the antimicrobial composition at a temperature and for a period of time effective to substantially inhibit bacterial growth of the at least one type of gram-positive bacteria while substantially maintaining the physiological characteristics of the tissue.
    Type: Application
    Filed: March 11, 2010
    Publication date: September 16, 2010
    Applicant: CRYOLIFE, INC.
    Inventors: Steven Walsh, Joseph Hamby, Chad Chinich
  • Patent number: 7763081
    Abstract: The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.
    Type: Grant
    Filed: February 3, 2005
    Date of Patent: July 27, 2010
    Assignee: Cryolife, Inc.
    Inventors: Jeremy D. Ollerenshaw, Steven Goldstein, Kirby S. Black
  • Patent number: D726818
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: April 14, 2015
    Assignee: Cryolife, Inc.
    Inventor: Mark John Yosick