Patents Assigned to Cryolife, Inc.
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Publication number: 20190290481Abstract: Apparatus and methods for accomplishing fluid drainage and localized cooling of the central nervous system broadly encompassing an intrathecal catheter assembly accomplishing drainage and cooling, and a console apparatus that may contain control, cooling, and drainage subsystems, and use thereof.Type: ApplicationFiled: March 22, 2019Publication date: September 26, 2019Applicant: CryoLife, Inc.Inventors: Adam William Martinez, Rachel Candace Howell, Emily Renee Croft, Jeremy Gura, Alejandro A. Aviles
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Patent number: 8883408Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.Type: GrantFiled: January 30, 2013Date of Patent: November 11, 2014Assignee: CryoLife, Inc.Inventors: Joseph Hamby, Steven Walsh
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Publication number: 20140271904Abstract: A method is provided for preparing a biological tissue for implantation. The method includes providing a biological tissue from a human or animal donor, treating the biological tissue with an antiviral treatment formulation, lysing the biological tissue, decellularizing the biological tissue with a decellularization treatment formulation, and decontaminating the biological tissue with an alkaline alcohol solution. The antiviral treatment formulation may include a solution of peracetic acid and an alcohol, wherein the peracetic acid is present in the antiviral treatment formulation at a concentration from about 0.03% to about 1.2% (v/v). The decellularization solution may include a solution of a polar aprotic solvent, such as dimethyl sulfoxide, benzyl alcohol and ethanol.Type: ApplicationFiled: March 7, 2014Publication date: September 18, 2014Applicant: CryoLife, Inc.Inventors: Joseph Hamby, Steven Goldstein, Valerie Rohde
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Publication number: 20140180190Abstract: An apparatus and method are provided to treat a stenosis. A delivery device is provided that has an elongate tubular member coupled therewith. The elongate tubular member has an outside surface that is configured to prevent adherence of in vivo matter. The tubular member has a proximal end and a distal end and is reinforced along its length to maintain open lumen under a transverse load. The tubular member is placed in the vasculature such that the distal end of the elongate tubular member is disposed distal of a stenosis. The proximal end of the elongate tubular member is disposed inside the vessel, preferably at a location proximal of the stenosis. Thereafter, after a therapeutic period, the elongate tubular member is removed intact.Type: ApplicationFiled: February 27, 2014Publication date: June 26, 2014Applicant: CryoLife, Inc.Inventors: Mitchell Dann, Judson A. Herrig, Stephen Hohmann
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Patent number: 8475827Abstract: A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof.Type: GrantFiled: July 6, 2010Date of Patent: July 2, 2013Assignee: CryoLife, Inc.Inventors: Joseph Hamby, Steven Walsh, Al Heacox, Steven Goldstein, David Gale, Stacy Arnold, Ann Sands Updegrove
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Patent number: 8377143Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.Type: GrantFiled: July 6, 2010Date of Patent: February 19, 2013Assignee: CryoLife, Inc.Inventors: Joseph Hamby, Steven Walsh
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Patent number: 8071124Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.Type: GrantFiled: January 26, 2005Date of Patent: December 6, 2011Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Ana T. Bird, Kirby S. Black
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Patent number: 8057818Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.Type: GrantFiled: January 26, 2005Date of Patent: November 15, 2011Assignee: CryoLife, Inc.Inventors: K. Umit Yüksel, Ana T. Bird, Kirby S. Black
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Patent number: 7896920Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.Type: GrantFiled: October 31, 2007Date of Patent: March 1, 2011Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
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Patent number: 7763081Abstract: The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.Type: GrantFiled: February 3, 2005Date of Patent: July 27, 2010Assignee: Cryolife, Inc.Inventors: Jeremy D. Ollerenshaw, Steven Goldstein, Kirby S. Black
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Patent number: 7621954Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.Type: GrantFiled: December 8, 2006Date of Patent: November 24, 2009Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
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Patent number: 7621959Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms. the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.Type: GrantFiled: December 10, 2004Date of Patent: November 24, 2009Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
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Patent number: 7449315Abstract: Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed.Type: GrantFiled: March 30, 2007Date of Patent: November 11, 2008Assignee: Cryolife, Inc.Inventors: Carl W. Gilbert, Eleanor B. McGowan, Kirby S. Black, T. Gregory P. Harper
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Patent number: 7318998Abstract: The present invention relates, in general, to tissue decellularization and, in particular to a method of treating tissues, for example, heart valves, tendons and ligaments, so as to render them acellular and thereby limit mineralization and/or immunoreactivity upon implementation in vivo.Type: GrantFiled: March 24, 2003Date of Patent: January 15, 2008Assignee: Cryolife, Inc.Inventors: Steven Goldstein, Kirby S. Black
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Patent number: 7226615Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.Type: GrantFiled: November 7, 2001Date of Patent: June 5, 2007Assignee: CryoLife, Inc.Inventors: K. Ümit Yüksel, Ana T. Bird, Kirby S. Black
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Patent number: 7157458Abstract: Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed.Type: GrantFiled: January 31, 2002Date of Patent: January 2, 2007Assignee: Cryolife, Inc.Inventors: Carl W. Gilbert, Eleanor B. McGowan, Kirby S. Black, T. Gregory P. Harper
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Patent number: 7129035Abstract: This invention relates to the sterilization and preservation of tissue for storage. More specifically, the invention relates to a method of using a solution to form a preserved tissue. The solution includes a radical scavenger at a concentration believed to reduce the damage to the tissue that could otherwise occur during sterilization with ionizing radiation.Type: GrantFiled: December 11, 2003Date of Patent: October 31, 2006Assignee: CryoLife, Inc.Inventors: Steven Goldstein, Joseph Hamby, Steven P. Walsh, Kirby S. Black
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Publication number: 20050163819Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.Type: ApplicationFiled: January 26, 2005Publication date: July 28, 2005Applicant: Cryolife, IncInventors: K. Yuksel, Ana Bird, Kirby Black
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Patent number: 6921412Abstract: Self-supporting, shaped, three-dimensional cross-linked proteinaceous biopolymeric materials that may be implanted in vivo, and methods of making such materials are disclosed. The biopolymeric materials most preferably include reinforcing media, such as biocompatible fibrous or particulate materials. In use, the preformed, shaped biopolymeric materials may be applied to tissue in need of repair and then sealed around its edges with a liquid bioadhesive. In such a manner, repaired tissue which is capable of withstanding physiological pressures may be provided.Type: GrantFiled: May 12, 2000Date of Patent: July 26, 2005Assignee: Cryolife, Inc.Inventors: Kirby S. Black, K. Umit Yuksel, Aaron J. Trygstad
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Patent number: D726818Type: GrantFiled: July 17, 2014Date of Patent: April 14, 2015Assignee: Cryolife, Inc.Inventor: Mark John Yosick