Patents Assigned to CRYOMEDIX LLC
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Patent number: 9408655Abstract: A cryoablation apparatus includes a distal energy delivery section to facilitate energy transfer to the tissue, resulting in faster achievement of tissue target temperatures. The energy delivery section includes a first heat exchange region and a second heat exchange region having a different heat exchange efficiency than the first heat exchange region. The first heat exchange region may comprise an increased surface area along a radial portion or length of the cryoprobe in contact with surrounding tissue. The heat exchange region may include ridges, texture, threads, and microtubes which serve to increase the thermal-contacting surface area and provide enhanced cryoenergy to the tissue.Type: GrantFiled: October 27, 2011Date of Patent: August 9, 2016Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup, William Nydam
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Patent number: 9402676Abstract: Cryoablation balloon catheters and methods are described herein. The cryoablation balloon catheter comprises a distal end section and an inflatable balloon member disposed along the distal end section for contacting a target tissue. The balloon member may be inflated with a thermally conductive liquid. One or more cooling microtubes are positioned within the balloon and a single phase liquid coolant is transported from a liquid source, through the microtubes to the distal section, and returned to a reservoir. Cryogenic energy is transferred from the microtubes, through the conductive liquid filling the balloon, through the wall of the balloon, and to the tissue. In a cryoablation balloon catheter, a plurality of flexible microtubes are adhered to a surface of the expandable balloon. Cryoenergy from the microtubes is directly transferred to the tissue.Type: GrantFiled: August 26, 2011Date of Patent: August 2, 2016Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup, Barron Nydam, William Nydam
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Patent number: 9345527Abstract: A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.Type: GrantFiled: November 9, 2011Date of Patent: May 24, 2016Assignee: CRYOMEDIX, LLCInventors: Alexei V. Babkin, Peter J. Littrup, William J. Nydam
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Patent number: 8888768Abstract: A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.Type: GrantFiled: April 29, 2010Date of Patent: November 18, 2014Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup, William Nydam, Barron Nydam
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Patent number: 8845628Abstract: A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.Type: GrantFiled: October 8, 2012Date of Patent: September 30, 2014Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup, William Nydam, Barron Nydam
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Patent number: 8814850Abstract: A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.Type: GrantFiled: April 17, 2009Date of Patent: August 26, 2014Assignee: Cryomedix, LLCInventors: Alexei V. Babkin, Peter J. Littrup, William J. Nydam
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Patent number: 8685014Abstract: A system and method for use with at least one cryoprobe for the treatment of biological tissue controls the energy applied to the tissue. The invention receives live procedure data such as temperature information from locations along the pathway of the cryogenic liquids, and calculates a procedure signature or profile based on the procedure data. In one embodiment, volumetric isotherms are calculated. The procedure signature is compared to a planning signature based on previously acquired image data and estimates of the thermal gradients from models. The system and method are further configured to automatically regulate the application of power based on analysis of the planning data to the procedure data.Type: GrantFiled: November 1, 2012Date of Patent: April 1, 2014Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup
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Publication number: 20130345688Abstract: Cryoablation balloon catheters and methods are described herein. The cryoablation balloon catheter comprises a distal end section and an inflatable balloon member disposed along the distal end section for contacting a target tissue. The balloon member may be inflated with a thermally conductive liquid. One or more cooling microtubes are positioned within the balloon and a single phase liquid coolant is transported from a liquid source, through the microtubes to the distal section, and returned to a reservoir. Cryogenic energy is transferred from the microtubes, through the conductive liquid filling the balloon, through the wall of the balloon, and to the tissue. In a cryoablation balloon catheter, a plurality of flexible microtubes are adhered to a surface of the expandable balloon. Cryoenergy from the microtubes is directly transferred to the tissue.Type: ApplicationFiled: August 26, 2011Publication date: December 26, 2013Applicant: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup, Barron Nydam, William Nydam
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Patent number: 8475441Abstract: A system and method for use with at least one cryoprobe for the treatment of biological tissue controls the energy applied to the tissue. The invention receives live procedure data such as temperature information from locations along the pathway of the cryogenic liquids, and calculates a procedure signature or profile based on the procedure data. In one embodiment, volumetric isotherms are calculated. The procedure signature is compared to a planning signature based on previously acquired image data and estimates of the thermal gradients from models. The system and method are further configured to automatically regulate the application of power based on analysis of the planning data to the procedure data.Type: GrantFiled: December 21, 2009Date of Patent: July 2, 2013Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup
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Publication number: 20130060242Abstract: A system and method for use with at least one cryoprobe for the treatment of biological tissue controls the energy applied to the tissue. The invention receives live procedure data such as temperature information from locations along the pathway of the cryogenic liquids, and calculates a procedure signature or profile based on the procedure data. In one embodiment, volumetric isotherms are calculated. The procedure signature is compared to a planning signature based on previously acquired image data and estimates of the thermal gradients from models. The system and method are further configured to automatically regulate the application of power based on analysis of the planning data to the procedure data.Type: ApplicationFiled: November 1, 2012Publication date: March 7, 2013Applicant: CRYOMEDIX LLCInventor: CRYOMEDIX LLC
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Publication number: 20130041358Abstract: A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.Type: ApplicationFiled: October 8, 2012Publication date: February 14, 2013Applicant: CRYOMEDIX LLCInventor: CRYOMEDIX LLC
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Publication number: 20120253336Abstract: A method for cryo-induced renal neuromodulation includes applying cryoenergy to neural fibers that contribute to renal function, or to vascular structures that contact, feed or perfuse the neural fibers. In one embodiment, cryoenergy is applied via a distal energy-delivering section of a flexible catheter. The distal section may include a plurality of microtubes for transporting a cryogen to the distal tip. The energy-delivering section contacts and extracts heat from the wall of the renal artery. In one embodiment, the distal energy-delivering section is radially expandable. The renal nerve is cooled to a degree such that nerve function is disrupted.Type: ApplicationFiled: September 27, 2011Publication date: October 4, 2012Applicant: CRYOMEDIX, LLCInventors: Peter Littrup, Alexei Babkin, Barron Nydam, William Nydam
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Publication number: 20100280507Abstract: A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.Type: ApplicationFiled: April 29, 2010Publication date: November 4, 2010Applicant: CRYOMEDIX LLCInventors: Alexei BABKIN, Peter LITTRUP, William NYDAM, Barron NYDAM
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Publication number: 20100256621Abstract: Single phase liquid refrigerant cryoablation systems and methods are described herein. The cryoablation systems drive liquid cryogen or refrigerant along a closed fluid pathway without evaporation of the liquid cryogen. A cryoprobe includes a distal energy delivery section to transfer energy to the tissue. A plurality of cooling microtubes positioned in a distal section of the cryoprobe transfer cryogenic energy to the tissue. The plurality of microtubes in the distal section are made of materials which exhibit flexibility at cryogenic temperature ranges, enabling the distal section of the cryoprobe to bend and conform to variously shaped target tissues.Type: ApplicationFiled: April 5, 2010Publication date: October 7, 2010Applicant: CRYOMEDIX LLCInventors: Alexei BABKIN, Peter LITTRUP, William NYDAM, Barron NYDAM