Abstract: The present invention provides a general assay methodology suitable for the detection of organic analytes which are neither aldehydes nor ketones and for inorganic substances. The methodology utilizes prepared sensitized films of derivatizing agents and specific developer solutions for the selective and controlled formation of light scattering crystals whose presence serves as a qualitative and/or quantitative measure of the individual analyte of interest in the sample.
Abstract: A unique blood filter matrix material is provided which is able to effectively separate whole blood into cellular and noncellular constituents, especially when the whole blood volume is 0.5 milliliters or less. The filter matrix presents an overall negative surface electrical charge to the whole blood and utilizes a mechanism of action to rapidly separate cells from plasma or serum.
Type:
Grant
Filed:
November 17, 1988
Date of Patent:
August 7, 1990
Assignee:
Crystal Diagnostics, Inc.
Inventors:
James A. Laugharn, Denis Hammerton, Timothy W. Towle
Abstract: The present invention provides unique methods and apparatus for the detection of an analyte of interest in a fluid sample by selective oxidation of the analyte into a carbonyl-containing compound followed by the controlled formation and growth of optically visible crystals as a qualitative and quantitative measure of the analyte. Epoxides, alcohols, olefins, arylalkanes and alkyl halides are among the many different classes or chemical entities which can be selectively detected in the concomittant presence or absence of other substances within the test sample.