Abstract: Ion-selective sensor (6) comprising a micro-machined chip with an analyte micro-channel (2), adapted to draw an analyte solution and a first liquid membrane micro channel (3) adapted to draw a liquid membrane solution, and an first electrolyte micro channel (1), adapted to draw an analyte solution. The ion-selective sensor (6) comprises a first substrate (100) and a second substrate (200) comprising each a structured surface to form, after assembly of said substrates the analyte micro-channel (2), the first electrolyte micro channel (1) and the first liquid membrane micro channel (3), each provided with their respective inlet and outlet.

Abstract: The present invention concerns a method for constructing a light coupling system wherein a grating is manufactured on the surface of a multimode waveguide and defines the entrance of the waveguide for an incident light beam, said grating comprising a repetition of patterns. The grating is defined by a set of parameters comprising: •grating period (P), separating two adjacent patterns, •grating depth (d) between the highest and the lowest point of the pattern, •incident angle mean value (?) of the incident light with respect to the waveguide. The method comprises a step of optimization of the set of parameters to obtain an optimized second set of parameters, in order to obtain a transmission efficiency (Ce) of the incident light into said waveguide for the first or the second diffractive order exceeding 35% for unpolarized light, or exceeding 50% for polarized light, at a given wavelength of the incident light.

Abstract: A device for the sensitive detection of X-rays comprises a structured scintillator screen optically coupled to a semiconductor image sensor. The scintillator screen comprises individual columnar elements covered with material showing high optical reflection. Each columnar element represents a pixel, and light flashes created by an X-ray photon in a scintillating event exit through a short surface of the columnar element for detection with a semiconductor image sensor. The semiconductor image sensor comprises a multitude of photosensor elements, and one or more of these photosensor elements receives light from a scintillator screen pixel.

Abstract: An ion sensitive system has sets of microfluidic microchannels forming ion sensitive electrodes by the assembly of a substrate with structured microchannels and another substrate including metal contacts on its surface. The integrated ion sensitive sensors are each composed of a microfluidic microchannel to contain an electrolyte, another microfluidic microchannel to contain the analyte and another microfluidic microchannel to contain a membrane liquid that separates the electrolyte from the analyte at the confluent junction of the three solutions. The system has the dimension of a thin and small disc and can be incorporated in an analyzing device.

Abstract: A method for working out the angular position of a rotating element, by using at least one fixed light source emitting a light beam in the direction of a fixed sensor, arranging the light source with respect to the rotating element and sensor to induce an interaction between the beam and sensor, and providing a value of the angular position dependent of the sensor's output signal. The method including: arranging on the path of the beam a code-disc presenting a two-dimensional pattern of transparent and opaque areas and an absolute code integral with the rotating element, using the image casted by the code-disc on the sensor for determining the eccentricity of the code-disc in dependence of the angular position of the rotating element, using the eccentricity for compensating the value of the computed angular position, and computing a corrected angular position of the rotating element.

Abstract: The present invention discloses a method for manufacturing a zero-order diffractive filter comprising a high-index material having an upper surface and a lower surface. The high-index material is positioned between a first low-index matter and a second low-index matter; the lower surface is adjacent to said first low-index matter and the upper surface is adjacent to the second low-index matter. Moreover, the high-index material has an index of refraction that is higher than the index of refraction of both said first low-index matter and said second low-index matter. The method comprises at least the following procedure: selectively providing, by employing at least one wet-coating technique, at least one of the following at least partially: the high-index material onto said first low-index matter.

Abstract: The present invention relates to a pipette tip (100, 200, 201, 300) comprising a tip body (110) having an inner surface and an outer surface (112). The inner surface (111) defines an inner cavity (120, 320), which has an upper end and a lower end. The upper end has an upper opening (131); and the lower end has a lower opening (141). At least a part of the inner surface (111) is provided with capturing agents (151) of at least one type forming at least one capturing-agent region (150) on the at least one inner surface. The at least one capturing agent region (150) is capable of selectively binding target substances (152) of at least one type comprised in a sample to form at least agent-target conjugates (155), the arrangement of which define at least one agent-target region (156).

Abstract: A sensor which reacts on influences from an environment. The sensor includes a zero-order diffractive color filter. The zero-order diffractive color filter includes a high-index waveguide layer, a zero-order diffractive grating structure and a layer of an reactive material, wherein the reactive material is in contact with the environment and wherein the reactive material changes its optical properties upon interaction with the environment. The reactive material is embedded in the waveguide layer and/or the reactive material is located at a maximum distance d from the waveguide layer. The distancing is effected by an intra layer having a low index of refraction.

Abstract: A method for fabricating a micromechanical part from a substrate in which the part is fabricated by providing a plurality of fasteners between the part and the substrate, the fasteners being sacrificial, characterized in that the fasteners include at least one hinge at the end of each fastener located beside the part, and in that the method includes a step of breaking the sacrificial fasteners. The micromechanical parts employing this type of sacrificial fastener are also described.

Abstract: The present invention relates to a method for producing a microfabricated atomic vapor cell, including a step of forming at least one cavity in a substrate and closing the cavity at one side. The method further includes: —a step of depositing a solution including an alkali metal azide dissolved in at least one of its solvents, —a step of evaporating such solvent for forming a recrystallized alkali metal azide, —a step of decomposing the recrystallized alkali metal azide in an alkali metal and nitrogen, such alkali metal depositing in the cavity of the substrate.

Abstract: The present invention discloses a microinjection apparatus (100) for microinjection of substances into individual substances comprising at least one carrier (120, 130) on which at least one sample is immobilizable. In embodiments, the apparatus comprises at drivable support (110) on which at least one carrier is positioned, wherein the support drives the at least one carrier in a closed loop to a respective plurality of stations along the loop. The plurality of stations constitutes at least one sample-substance-providing station (141), at least one sample-substance microinjection station (142) and at least one sample-extraction station (143).

Abstract: Method for working out the angular position of a rotating element, using at least one light source emitting a light beam in the direction of a fixed sensor and computing elements for processing an output signal of the sensor, includes: arranging the light source with respect to the rotating element and the sensor so as to induce an interaction between the light beam and the sensor which depends on the angular position of the rotating shaft, arranging on the path of the light beam, in a fixed position with respect to the sensor, a perforated mask which presents a repetitive pattern of perforations, detecting shadows generated by the mask on the sensor, processing the output signal of the sensor for determining the position of the shadows on the sensor, and computing the angular position of the rotating element using the position of the shadows.

Abstract: A security device including a zero order diffractive microstructure buried within a substrate. One or more optical structures, such as microlenses, may be formed on a surface of the substrate. The optical structures modify the optical characteristics of the zero order diffractive microstructure. Various alternatives or additional optical structures and methods of producing the security device are described in additional embodiments.

Abstract: Method for determining the position and/or displacement of a mobile element with respect to a fixed frame, includes using a fixed light source emitting a light beam, arranging the source with respect to the mobile element and a sensor to induce an interaction between the beam and sensor, using a concave mirror, integral in movement with the mobile element, for reflecting the beam in direction to the sensor, arranging on the path of the beam a fixed optical mask which presents a two dimensional regular pattern interlaced with an absolute code, detecting and processing the image casted by the mask on the sensor, computing the displacement value of the image on the sensor and using the computed displacement value for computing and providing the position and/or the displacement in at least one direction of the mobile element in dependence of the image's displacement.

Abstract: A device for an atomic clock, including: a laser source (102) that generates a laser beam; a splitter (101) that makes it possible to divert and allow a portion of the laser beam to pass therethrough in accordance with a predefined percentage; a quarter-wave plate (105) that modifies the linear polarization of the laser beam into circular polarization and vice versa; a gas cell arranged on the circular polarization laser beam; a mirror (107) sending the laser beam back toward the gas cell (106); a first photodetector (108a), and a polarizer (103) arranged between the laser beam outlet and the splitter in order to protect the laser source from the retroreflections emitted by different optical elements constituting the device.

Abstract: A device for an atomic clock, including: a laser source (102) generating a laser beam; a quarter-wave plate (105) modifying the linear polarization of the laser beam into a circular polarization and vice versa; a gas cell (106) placed on the laser beam having a circular polarization; a mirror (107) sending the laser beam back toward the gas cell; a first photodetector (108a); means (103, 101a, 107) for diverting the reflected beam of the laser source (102), and a second photodetector (109) placed behind the mirror (107), the mirror being semitransparent and allowing a portion of the laser beam to pass therethrough, the second photodetector (109) being used for controlling the optical frequency of the laser and/or for controlling the temperature of the cell (106).

Abstract: A spectrometer includes: an entrance aperture, a collimator, intended to produce, from a light source, a collimated input light (5), a plurality of gratings arranged in a 2-D matrix, a plurality of detectors, and an exit aperture.

Abstract: The current invention relates, inter alia, to charge pulse amplitude and time detecting circuits, offering very low amplitude and temporal noise, and overcoming noise performance limits in charge pulse detection circuits according to prior art. Embodiments of the present invention may include a sensing device delivering charge pulses onto a sense node, an active buffer buffering the voltage on the sense node with a low impedance, a recharge device removing signal charge from the sense node, a noise filter connected to the output of the active buffer transmitting signal voltage pulses while attenuating noise from the recharge device. Additional and alternative embodiments are specified and claimed.

Abstract: A one-dimension position measurement system includes: a first ruler having a first one-dimension binary code si applied thereon, a camera for acquiring a picture of a portion of the code si, the portion having a length of I bits, and some processing elements. Each codeword of length I of the one-dimension code si is unique within the whole code si. A codeword ai is read from the acquired picture, and the processing elements are implemented for computing an absolute position p of the codeword ai of the code si from: (I). An ad-hoc interpolation method is used to obtain a precision way below the distance between two bits of the codewords. The code si may be applied on the ruler by using some geometric primitives, a geometric primitive for encoding a “1” being different from a geometric primitive for encoding a “0”, both having the same horizontal projection. The horizontal projection is then used for fine interpolation, achieving nanometer-scale resolution.

Abstract: The present disclosure concerns a method for determining a heart-lung interaction factor of a subject, comprising: measuring a heart activity-related signal comprising heart activity-related information; from the heart activity-related signal, calculating a frequency of cardiac cycle and a frequency of respiratory cycle; from the heart activity-related signal, determining a cardiac cycle energy at the frequency of cardiac cycle, determining a respiratory cycle energy at the frequency of respiratory cycle, and determining a heart-lung interaction energy at an intermodulation frequency corresponding to the difference between the frequency of respiratory cycle and the frequency of cardiac cycle, or the sum of the frequency of respiratory cycle and the frequency of cardiac cycle; and determining a heart-lung interaction factor from the ratio of the heart-lung interaction energy and one of the cardiac cycle energy and the respiratory cycle energy. The heart-lung interaction factor can be determined non-invasively.